Summary

Name XIAP
Full Name E3 ubiquitin-protein ligase XIAP
Synonyms Baculoviral IAP repeat-containing protein 4, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP | API3, BIRC4, IAP3
Primary ID P98170
Links - -
Type protein
Relations 19
Pathways Death Receptor Signaling, Parkinson disease, Inhibition of Apoptosis
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation XIAP 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary Cancer Cell
Pathways:Inhibition of Apoptosis
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation XIAP 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary Cancer Cell
Pathways:Parkinson disease
+ up-regulates img/direct-activation.png phosphorylation XIAP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding XIAP 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding XIAP 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding XIAP 0.64
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CASP9 0.81
Publications: 3 Organism: Homo Sapiens, In Vitro
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson disease
+ down-regulates activity img/direct_inhibition.png binding CASP3 0.57
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson disease
+ down-regulates activity img/direct_inhibition.png binding XIAP 0.64
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ down-regulates quantity img/direct_inhibition.png binding XIAP 0.64
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CASP7 0.5
Publications: 2 Organism: In Vitro
Pathways:Inhibition of Apoptosis
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DIABLO 0.69
Publications: 1 Organism: In Vitro
Pathways:Death Receptor Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CASP3 0.57
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson disease
+ down-regulates img/direct_inhibition.png binding XIAP 0.37
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson disease