Summary
| Name |  XIAPView Modifications |
| Full Name | E3 ubiquitin-protein ligase XIAP |
| Synonyms | Baculoviral IAP repeat-containing protein 4, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP | API3, BIRC4, IAP3 |
| Primary ID | P98170 |
| Links |  -  -  |
| Type | protein |
| Relations | 19 |
| Pathways | Death Receptor Signaling, Parkinson disease, Inhibition of Apoptosis |
| Function | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT | up-regulates quantity by stabilization 
phosphorylation
|
XIAP | 0.14 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Ovary Cancer Cell | |||
| Pathways: | Inhibition of Apoptosis | |||
| + | AKT1 | up-regulates quantity by stabilization
phosphorylation
|
XIAP | 0.14 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Ovary Cancer Cell | |||
| Pathways: | Parkinson disease | |||
| + | AKT2 | up-regulates
phosphorylation
|
XIAP | 0.14 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BIRC5 | up-regulates
binding
|
XIAP | 0.28 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | XAF1 | down-regulates 
binding
|
XIAP | 0.35 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DIABLO | down-regulates
binding
|
XIAP | 0.64 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Death Receptor Signaling | |||
| + | XIAP | down-regulates quantity by destabilization
binding
|
CASP9 | 0.81 |
| Publications: | 3 | Organism: | Homo Sapiens, In Vitro | |
| Pathways: | Death Receptor Signaling, Inhibition of Apoptosis, Parkinson disease | |||
| + | XIAP | down-regulates activity
binding
|
CASP3 | 0.57 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Death Receptor Signaling, Inhibition of Apoptosis, Parkinson disease | |||
| + | DIABLO | down-regulates activity
binding
|
XIAP | 0.64 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Death Receptor Signaling | |||
| + | DIABLO | down-regulates quantity
binding
|
XIAP | 0.64 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Death Receptor Signaling | |||
| + | XIAP | down-regulates quantity by destabilization
binding
|
CASP7 | 0.5 |
| Publications: | 2 | Organism: | In Vitro | |
| Pathways: | Inhibition of Apoptosis | |||
| + | XIAP | down-regulates quantity by destabilization
ubiquitination
|
DIABLO | 0.69 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | Death Receptor Signaling | |||
| + | XIAP | down-regulates quantity by destabilization
ubiquitination
|
CASP3 | 0.57 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Death Receptor Signaling, Inhibition of Apoptosis, Parkinson disease | |||
| + | HTRA2 | down-regulates
binding
|
XIAP | 0.37 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Parkinson disease | |||