Summary

Name XIAP
Full Name E3 ubiquitin-protein ligase XIAP
Synonyms Baculoviral IAP repeat-containing protein 4, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP | API3, BIRC4, IAP3
Primary ID P98170
Links - -
Type protein
Relations 31
Pathways Death Receptor Signaling, Inhibition of Apoptosis, Parkinson
Inhibitors embelin
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation XIAP 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary Cancer Cell
Pathways:Inhibition of Apoptosis
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation XIAP 0.621
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary Cancer Cell
Pathways:Parkinson
+ up-regulates img/direct-activation.png phosphorylation XIAP 0.421
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation XIAP 0.396
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png polyubiquitination RIPK4 0.334
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DIABLO 0.915
Publications: 1 Organism: In Vitro
Pathways:Death Receptor Signaling
+ down-regulates activity img/direct_inhibition.png binding CASP3 0.94
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson
+ down-regulates activity img/direct_inhibition.png binding XIAP 0.915
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ down-regulates quantity img/direct_inhibition.png binding XIAP 0.915
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ up-regulates activity img/direct-activation.png ubiquitination TLE3 0.504
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination XIAP 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination OGT 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CASP9 0.923
Publications: 3 Organism: Homo Sapiens, In Vitro
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson
+ down-regulates img/direct_inhibition.png binding XIAP 0.915
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ down-regulates img/direct_inhibition.png binding XIAP 0.561
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CASP7 0.859
Publications: 2 Organism: In Vitro
Pathways:Inhibition of Apoptosis
+ down-regulates quantity img/direct_inhibition.png ubiquitination PTEN 0.69
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition XIAP 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding XIAP 0.709
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson
+ up-regulates activity img/direct-activation.png ubiquitination HIF1A 0.284
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding XIAP 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CASP3 0.94
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson
+ down-regulates quantity img/direct_inhibition.png ubiquitination CDC42 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AIFM1 0.436
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination SEPTIN4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding XIAP 0.496
Publications: 1 Organism: Homo Sapiens