Relation Results

Summary

Name XIAP
Full Name E3 ubiquitin-protein ligase XIAP
Synonyms Baculoviral IAP repeat-containing protein 4, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP | API3, BIRC4, IAP3
Primary ID P98170
Links - -
Type protein
Relations 31
Pathways Death Receptor Signaling, Inhibition of Apoptosis, Parkinson
Inhibitors embelin
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, ...
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Type: Score: Layout: SPV 
0.6220.4220.20.3960.9140.940.9230.8590.6890.80.7090.2850.20.40.5030.4360.20.20.20.5620.3340.4970.914AKT1XIAPAKT2AKTGSK3BDIABLOCASP3CASP9CASP7PTENembelinHTRA2HIF1ASEPTIN4CDC42TLE3AIFM1Ub:E2OGTXAF1RIPK4BIRC5

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ AKT1up-regulates quantity by stabilization img/direct-activation.png phosphorylation XIAP 0.622
Identifier Residue Sequence Organism Cell Line
SIGNOR-119488 Ser87 VGRHRKVsPNCRFIN Homo sapiens
pmid sentence
Akt, including akt1 and akt2, interacts with and phosphorylates x-linked inhibitor of apoptosis protein (xiap) at residue serine-87 in vitro and in vivo. Phosphorylation of xiap by akt protects xiap from ubiquitination and degradation in response to cisplatin.
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary Cancer Cell
Pathways:Parkinson
+ AKT2up-regulates img/direct-activation.png phosphorylation XIAP 0.422
Identifier Residue Sequence Organism Cell Line
SIGNOR-119492 Ser87 VGRHRKVsPNCRFIN Homo sapiens
pmid sentence
Here, we demonstrate that akt, including akt1 and akt2, interacts with and phosphorylates x-linked inhibitor of apoptosis protein (xiap) at residue serine-87 in vitro and in vivo. Phosphorylation of xiap by akt protects xiap from ubiquitination and degradation in response to cisplatin. Moreover, autoubiquitination of xiap is also inhibited by akt.
Publications: 1 Organism: Homo Sapiens
+ AKTup-regulates quantity by stabilization img/direct-activation.png phosphorylation XIAP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-244377 Ser87 VGRHRKVsPNCRFIN Homo sapiens
pmid sentence
Akt, including akt1 and akt2, interacts with and phosphorylates x-linked inhibitor of apoptosis protein (xiap) at residue serine-87 in vitro and in vivo. Phosphorylation of xiap by akt protects xiap from ubiquitination and degradation in response to cisplatin.
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary Cancer Cell
Pathways:Inhibition of Apoptosis
+ GSK3Bup-regulates activity img/direct-activation.png phosphorylation XIAP 0.396
Identifier Residue Sequence Organism Cell Line
SIGNOR-277390 Thr180 WPDYAHLtPRELASA Homo sapiens HEK-293T Cell
pmid sentence
 We now demonstrate that XIAP is phosphorylated by GSK3 at threonine 180, and that an alanine mutant (XIAPT180A) exhibits decreased Wnt activity compared to wild-type XIAP in cultured human cells and in Xenopus embryos. 
Publications: 1 Organism: Homo Sapiens
+ DIABLOdown-regulates quantity img/direct_inhibition.png binding XIAP 0.914
Identifier Residue Sequence Organism Cell Line
SIGNOR-118411 Homo sapiens HEK-293 Cell, HeLa Cell
pmid sentence
Smac3, a novel Smac/DIABLO splicing variant, accelerates XIAP auto-ubiquitination and destruction
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ XIAPdown-regulates activity img/direct_inhibition.png binding CASP3 0.94
Identifier Residue Sequence Organism Cell Line
SIGNOR-71954 Homo sapiens
pmid sentence
The linker region located adjacent to the bir2 domain also participates in the binding of xiap to the effector caspases (-3 and -7).
Identifier Residue Sequence Organism Cell Line
SIGNOR-110837 Homo sapiens
pmid sentence
Xiap is an endogenous inhibitor of caspase-3
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson
+ XIAPdown-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CASP3 0.94
Identifier Residue Sequence Organism Cell Line
SIGNOR-109243 Homo sapiens
pmid sentence
Xiap promotes the degradation of active-form caspase-3, but not procaspase-3, in living cells. Both the association of XIAP with caspase-3 and the RING finger domain of XIAP were essential for ubiquitination. XIAP promotes the degradation of caspase-3, which enhances its anti-apoptotic effect.
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson
+ XIAPdown-regulates quantity by destabilization img/direct_inhibition.png binding CASP9 0.923
Identifier Residue Sequence Organism Cell Line
SIGNOR-105702 Homo sapiens
pmid sentence
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
Identifier Residue Sequence Organism Cell Line
SIGNOR-98988 in vitro
pmid sentence
This paper reports the crystal structure of caspase-9 in an inhibitory complex with the third baculoviral iap repeat (bir3) of xiap at 2.4 a resolution. X-linked inhibitor-of-apoptosis protein (xiap) interacts with caspase-9 and inhibits its activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-56484 Homo sapiens HEK-293 Cell
pmid sentence
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspasesThese findings demonstrate that IAPs can suppress different apoptotic pathways by inhibiting distinct caspases and identify pro-caspase-9 as a new target for IAP-mediated inhibition of apoptosis
Publications: 3 Organism: Homo Sapiens, In Vitro
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson
+ XIAPdown-regulates quantity by destabilization img/direct_inhibition.png binding CASP7 0.859
Identifier Residue Sequence Organism Cell Line
SIGNOR-110840 in vitro
pmid sentence
Xiap is an endogenous inhibitor of caspase-7
Identifier Residue Sequence Organism Cell Line
SIGNOR-105732 in vitro
pmid sentence
Our crystal structure of the complex between xiap (linker-bir2) and caspase-7 surprisingly revealed that the linker is the major determinant of binding and inhibition for the caspase.
Publications: 2 Organism: In Vitro
Pathways:Inhibition of Apoptosis
+ XIAPdown-regulates quantity img/direct_inhibition.png ubiquitination PTEN 0.689
Identifier Residue Sequence Organism Cell Line
SIGNOR-278751 Homo sapiens
pmid sentence
Finally, we found that XIAP can directly ubiquitinate PTEN in vitro.|Overexpression of XIAP induces polyubiquitination of PTEN and proteasome dependent decrease of PTEN protein levels.
Publications: 1 Organism: Homo Sapiens
+ embelindown-regulates activity img/direct_inhibition.png chemical inhibition XIAP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-262013 Homo sapiens Leukemia Cell
pmid sentence
Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells.
Publications: 1 Organism: Homo Sapiens
+ HTRA2down-regulates img/direct_inhibition.png binding XIAP 0.709
Identifier Residue Sequence Organism Cell Line
SIGNOR-110834 Homo sapiens
pmid sentence
Here we report that a serine protease called htra2/omi is released from mitochondria and inhibits the function of xiap by direct binding in a similar way to diablo.
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson
+ XIAPup-regulates activity img/direct-activation.png ubiquitination HIF1A 0.285
Identifier Residue Sequence Organism Cell Line
SIGNOR-278740 Homo sapiens
pmid sentence
HIF1alpha is ubiquitinated by XIAP.|Lys 63 -linked ubiquitination of HIF1alpha by XIAP is dependent on the activity of E2 ubiquitin conjugating enzyme Ubc13.|We find that XIAP and Ubc13 dependent Lys 63 -linked polyubiquitination promotes HIF1alpha nuclear retention leading to an increase in the expression of HIF1 responsive genes.|The data indicate that XIAP promotes the formation of the non-degradative Lys63-linked ubiquitin chains onto hypoxia inducible factor1\u03b1, but does not affect the formation of Lys48-linked chains.
Publications: 1 Organism: Homo Sapiens
+ SEPTIN4down-regulates quantity img/direct_inhibition.png binding XIAP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267671 Chlorocebus aethiops COS Cell
pmid sentence
The mitochondrial ARTS protein promotes apoptosis through targeting XIAP.|Binding of ARTS to XIAP is direct, as recombinant ARTS and XIAP proteins can bind to each other in vitro. ARTS binding to XIAP is specific and related to its pro-apoptotic function, as mutant forms of ARTS (or related septins) that fail to bind XIAP failed to induce apoptosis. ARTS leads to decreased XIAP protein levels and caspase activation. Our data suggest that ARTS induces apoptosis by antagonizing IAPs.
Publications: 1 Organism: Chlorocebus Aethiops
+ DIABLOdown-regulates activity img/direct_inhibition.png binding XIAP 0.914
Identifier Residue Sequence Organism Cell Line
SIGNOR-110831 Homo sapiens HEK-293 Cell, HeLa Cell
pmid sentence
Smac/diablo, an inhibitor of xiap, is released from mitochondria upon receiving apoptotic stimuli and binds to the bir2 and bir3 domains of xiap, thereby inhibiting its caspase-inhibitory activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-80218 Homo sapiens HeLa Cell
pmid sentence
Smac promotes caspase-9 activation by binding to inhibitor of apoptosis proteins, iaps, and removing their inhibitory activity.
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ XIAPdown-regulates quantity img/direct_inhibition.png ubiquitination CDC42 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-278799 Homo sapiens
pmid sentence
As XIAP can directly ubiquitinate Cdc42, we tested if the RING domain of XIAP is required for modulating the protein levels of Cdc42 in vivo .|We then investigated the molecular mechanisms behind XIAP mediated Cdc42 degradation.
Publications: 1 Organism: Homo Sapiens
+ XIAPup-regulates activity img/direct-activation.png ubiquitination TLE3 0.503
Identifier Residue Sequence Organism Cell Line
SIGNOR-278528 Homo sapiens
pmid sentence
These findings suggest that TLE3 ubiquitylation by XIAP may be required during Wnt pathway activation to facilitate its dissociation from TCF/Lef, allowing subsequent beta-catenin binding and transcriptional activation.
Publications: 1 Organism: Homo Sapiens
+ XIAPdown-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AIFM1 0.436
Identifier Residue Sequence Organism Cell Line
SIGNOR-278537 Homo sapiens
pmid sentence
Notably, cotransfection of XIAP along with AIF resulted in the complete inhibition of DNA degradation (21.2% degraded nuclei), suggesting that XIAP directly abrogates the ability of AIF to induce chromatin degradation.|XIAP binds and ubiquitinates AIF, and in this study, we determined the functional consequences of XIAP-mediated AIF ubiquitination.
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination XIAP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271045 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
+ XIAPdown-regulates quantity img/direct_inhibition.png ubiquitination OGT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278800 Homo sapiens
pmid sentence
These results demonstrate that XIAP acts as an E3 ubiquitin ligase and ubiquitinates OGT in HCT116 colon cancer cells.|XIAP promotes the ubiquitin-dependent proteasomal degradation of OGT.
Publications: 1 Organism: Homo Sapiens
+ XIAPdown-regulates quantity img/direct_inhibition.png ubiquitination SEPTIN4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278801 Homo sapiens
pmid sentence
Fig. 1 D revealed that co-transfection of ARTS and full length XIAP strongly reduces the levels of ARTS, while co-transfection of ARTS and XIAPdelRING does not change ARTS protein levels.|In this study we show that XIAP also promotes the ubiquitination and degradation of its antagonist ARTS.
Publications: 1 Organism: Homo Sapiens
+ XAF1down-regulates img/direct_inhibition.png binding XIAP 0.562
Identifier Residue Sequence Organism Cell Line
SIGNOR-155637 Homo sapiens
pmid sentence
Immunoprecipitation studies indicate that xaf1 binds to xiap,birc2,birc3.
Publications: 1 Organism: Homo Sapiens
+ DIABLOdown-regulates img/direct_inhibition.png binding XIAP 0.914
Identifier Residue Sequence Organism Cell Line
SIGNOR-171770 Homo sapiens
pmid sentence
Smac promotes caspase-9 activation by binding to inhibitor of apoptosis proteins, iaps, and removing their inhibitory activity.
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ XIAPup-regulates activity img/direct-activation.png polyubiquitination RIPK4 0.334
Identifier Residue Sequence Organism Cell Line
SIGNOR-272716 Homo sapiens HEK-293 Cell
pmid sentence
In this study, we report that in addition to RIP1 and RIP2, also RIP3 and RIP4 directly interact with XIAP, cIAP1 and cIAP2. When comparing the ability of these IAPs to directly conjugate RIP1–RIP4 with ubiquitin chains, we found that cIAP1 was the most effective E3 and was capable of ubiquitinating all four RIPs in the presence of the E2 component UbcH5a. On the contrary, XIAP was only capable of inducing weak ubiquitination of RIP4.
Publications: 1 Organism: Homo Sapiens
+ BIRC5up-regulates img/direct-activation.png binding XIAP 0.497
Identifier Residue Sequence Organism Cell Line
SIGNOR-126367 Homo sapiens
pmid sentence
Formation of a survivin-xiap complex promotes increased xiap stability against ubiquitination/proteasomal destruction and synergistic apoptosis
Publications: 1 Organism: Homo Sapiens
+ XIAPdown-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DIABLO 0.914
Identifier Residue Sequence Organism Cell Line
SIGNOR-134504 in vitro
pmid sentence
Xiap functions as ubiquitin ligase toward smac to inhibit apoptosis.
Publications: 1 Organism: In Vitro
Pathways:Death Receptor Signaling
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