Summary

Name MYD88
Full Name Myeloid differentiation primary response protein MyD88
Synonyms MYD88_HUMAN
Primary ID Q99836
Links - -
Type protein
Relations 14
Pathways COVID-19 Causal Network, EBV infection, Innate Immune Response, IL1 Signaling , Inflammosome Activation, Macrophage: IL1 beta, Monocyte: IL10 transcriptional regulation, Satellite: IL1 , SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
Function Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding DHX36 0.503
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MYD88 0.621
Publications: 2 Organism: Homo Sapiens
Pathways:EBV infection, Innate Immune Response, Toll like receptors
+ up-regulates activity img/direct-activation.png binding IRAK1 0.841
Publications: 1 Organism: Mus Musculus
Pathways:Innate Immune Response, IL1 Signaling , Toll like receptors
+ up-regulates activity img/direct-activation.png binding IRAK4 0.945
Publications: 2 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ up-regulates activity img/direct-activation.png binding MYD88 0.945
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ up-regulates activity img/direct-activation.png binding DHX9 0.469
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TRAF3 0.715
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE
+ up-regulates activity img/direct-activation.png binding MYD88 0.765
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding MYD88 0.2
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ up-regulates activity img/direct-activation.png binding TRAF6 0.92
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, Innate Immune Response, IL1 Signaling , Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ up-regulates activity img/direct-activation.png binding MYD88 0.697
Publications: 1 Organism: Mus Musculus
Pathways:EBV infection
+ up-regulates activity img/direct-activation.png binding MYD88 0.661
Publications: 1 Organism: Mus Musculus
Pathways:EBV infection