Summary

Name MYD88
Full Name Myeloid differentiation primary response protein MyD88
Synonyms MYD88_HUMAN
Primary ID Q99836
Links - -
Type protein
Relations 8
Pathways Toll like receptors, IL1 Receptor
Function Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding MYD88 0.8
Publications: 2 Organism: Homo Sapiens
Pathways:Toll like receptors
+ up-regulates activity img/direct-activation.png binding MYD88 0.6
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding IRAK1 0.69
Publications: 1 Organism: Mus Musculus
Pathways:IL1 Receptor, Toll like receptors
+ up-regulates activity img/direct-activation.png binding IRAK4 0.83
Publications: 2 Organism: Homo Sapiens
Pathways:IL1 Receptor
+ up-regulates activity img/direct-activation.png binding TRAF3 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding MYD88 0.48
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor