Summary

Name FLT3
Full Name Receptor-type tyrosine-protein kinase FLT3
Synonyms FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1 | CD135, FLK2, STK1
Primary ID P36888
Links - -
Type protein
Relations 30
Pathways Acute Myeloid Leukemia
Inhibitors Quizartinib; Tandutinib; CHIR-124; TG101209; KW-2449; Dovitinib; MK-2461; dovitinib; bis(lactic acid); 1,9-Pyrazoloanthrone; Sunitinib malate
Function Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation SHC1 0.18
Publications: 3
+ up-regulates img/direct-activation.png phosphorylation FLT3
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png phosphorylation STAT5A
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown Skeletal Muscle Differentiation
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/indirect-activation.png unknown AKT
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CEBPB 0.05
Publications: 1
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FLT3
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png binding GRB2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png binding PTPN11
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown AKT1 0.10
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CEBPA 0.49
Publications: 1
Pathways:Acute Myeloid Leukemia
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SPI1 0.03
Publications: 1
Pathways:Acute Myeloid Leukemia