Glioblastoma Multiforme

Pathway ID: SIGNOR-GBMView in NDEx

Description: Glioblastoma Multiforme (GBM) is one of the most common and aggresive type of brain cancers. Ninetyseven percent of tumors belong to the 'classical' subtype, and carry extra copies of the epidermal growth factor receptor (EGFR) gene, and most have higher than normal expression of epidermal growth factor receptor (EGFR), whereas the gene TP53, which is often mutated in glioblastoma, is rarely mutated in this subtype. Downstream signaling of many RTKs, including EGFR, lead to activation of the PI3K/AKT/mTOR and RAS/RAF/MAPK secondary messenger systems. Dysregulation of these intracellular signaling pathways often occurs in GBM.PTEN is an endogenous inhibitor of PI3K and RAS, and it is often lost or mutated in GBM. Other signaling molecules in the PI3K and RAS pathways are also commonly mutated in GBM. These alterations further contribute to inappropriate P13K and RAS activity in GBM.

Curated by: Livia Perfetto

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

25 Seed Entities

Organism:
Name Primary ID
HRAS P01112
BRAF P15056
NF1 P21359
PTEN P60484
CREB1 P16220
CBL P22681
SOS1 Q07889
EGF P01133
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate CHEBI:16618
Cell Growth SIGNOR-PH33
JUN P05412
RASA1 P20936
mTORC1 SIGNOR-C3
KRAS P01116
Proliferation SIGNOR-PH4
ELK1 P19419
GRB2 P62993
PIK3R1 P27986
MEK1/2 SIGNOR-PF25
PIK3CA P42336
ERK1/2 SIGNOR-PF1
EGFR P00533
PDPK1 O15530
Survival SIGNOR-PH13
AKT SIGNOR-PF24