Summary

Name GNA12
Full Name Guanine nucleotide-binding protein subunit alpha-12
Synonyms G alpha-12, G-protein subunit alpha-12
Primary ID Q03113
Links - -
Type protein
Relations 11
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding GNA12 0.24
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RHOA 0.23
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA12 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA12 0.35
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png unknown GNA12 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA12 0.52
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA12 0.19
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA12 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA12 0.44
Publications: 1 Organism: Homo Sapiens