Summary

Name NCOA1
Full Name Nuclear receptor coactivator 1
Synonyms NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 | BHLHE74, SRC1
Primary ID Q15788
Links - -
Type protein
Relations 19
Pathways Glucocorticoid Receptor, ASXL1 in AML
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation NCOA1 0.14
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates img/direct-activation.png phosphorylation NCOA1 0.14
Publications: 3 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NCOA1 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates activity img/direct-activation.png binding ASXL1 0.31
Publications: 1 Organism: Homo Sapiens
Pathways:ASXL1 in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PCK2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation APOC3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALDOB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding STAT5A 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/indirect-activation.png PGR 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NCOA1 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:ASXL1 in AML
+ up-regulates quantity img/indirect-activation.png transcriptional activation RARA 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:ASXL1 in AML
+ up-regulates img/direct-activation.png binding STAT5B 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation APOA5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP7A1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ESR1 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OTC 0.14
Publications: 1 Organism: Homo Sapiens