Summary

Name WWC1
Full Name Protein KIBRA
Synonyms HBeAg-binding protein 3, Kidney and brain protein, KIBRA, WW domain-containing protein 1 | KIAA0869
Primary ID Q8IX03
Links - -
Type protein
Relations 12
Function Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation WWC1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation WWC1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation WWC1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ img/unknown.png phosphorylation WWC1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation WWC1 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation WWC1 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation WWC1 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Breast
+ img/unknown.png phosphorylation WWC1 0.31
Publications: 2 Organism: In Vitro