| + |
CREBBP | down-regulates activity 
acetylation
|
FBL |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275898 |
Lys102 |
GVFICRGkEDALVTK |
|
|
| pmid |
sentence |
| 30540930 |
Here, we show that FBL is acetylated at several lysine residues by the acetyltransferase CBP and deacetylated by SIRT7.|hyperacetylation impairs the interaction of FBL with histone H2A and chromatin, thereby compromising H2AQ104 methylation (H2AQ104me) and rDNA transcription. SIRT7-dependent deacetylation of FBL ensures H2AQ104me and high levels of rRNA synthesis during interphase. |Global acetylome studies have shown that FBL is acetylated at four conserved lysine residues (K102, K121, K205, and K206) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275899 |
Lys121 |
GESVYGEkRVSISEG |
|
|
| pmid |
sentence |
| 30540930 |
Here, we show that FBL is acetylated at several lysine residues by the acetyltransferase CBP and deacetylated by SIRT7.|hyperacetylation impairs the interaction of FBL with histone H2A and chromatin, thereby compromising H2AQ104 methylation (H2AQ104me) and rDNA transcription. SIRT7-dependent deacetylation of FBL ensures H2AQ104me and high levels of rRNA synthesis during interphase. |Global acetylome studies have shown that FBL is acetylated at four conserved lysine residues (K102, K121, K205, and K206) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275896 |
Lys205 |
RDLINLAkKRTNIIP |
|
|
| pmid |
sentence |
| 30540930 |
Here, we show that FBL is acetylated at several lysine residues by the acetyltransferase CBP and deacetylated by SIRT7.|hyperacetylation impairs the interaction of FBL with histone H2A and chromatin, thereby compromising H2AQ104 methylation (H2AQ104me) and rDNA transcription. SIRT7-dependent deacetylation of FBL ensures H2AQ104me and high levels of rRNA synthesis during interphase. |Global acetylome studies have shown that FBL is acetylated at four conserved lysine residues (K102, K121, K205, and K206) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275897 |
Lys206 |
DLINLAKkRTNIIPV |
|
|
| pmid |
sentence |
| 30540930 |
Here, we show that FBL is acetylated at several lysine residues by the acetyltransferase CBP and deacetylated by SIRT7.|hyperacetylation impairs the interaction of FBL with histone H2A and chromatin, thereby compromising H2AQ104 methylation (H2AQ104me) and rDNA transcription. SIRT7-dependent deacetylation of FBL ensures H2AQ104me and high levels of rRNA synthesis during interphase. |Global acetylome studies have shown that FBL is acetylated at four conserved lysine residues (K102, K121, K205, and K206) |
|
| Publications: |
4 |
| + |
CREBBP | down-regulates activity
acetylation
|
DDX21 |
0.247 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275904 |
Lys137 |
PKKMKKEkEMNGETR |
|
|
| pmid |
sentence |
| 28790157 |
Significantly, the activity of DDX21 is regulated by acetylation. Acetylation by CBP inhibits DDX21 activity, while deacetylation by SIRT7 augments helicase activity and overcomes R-loop-mediated stalling of RNA polymerases.|acetylation of K18, K137, and K600 impairs the helicase activity of DDX21. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275902 |
Lys18 |
LESDTAMkKGETLRK |
|
|
| pmid |
sentence |
| 28790157 |
Significantly, the activity of DDX21 is regulated by acetylation. Acetylation by CBP inhibits DDX21 activity, while deacetylation by SIRT7 augments helicase activity and overcomes R-loop-mediated stalling of RNA polymerases.|acetylation of K18, K137, and K600 impairs the helicase activity of DDX21. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275906 |
Lys600 |
HFKQSAEkLIEEKGA |
|
|
| pmid |
sentence |
| 28790157 |
Significantly, the activity of DDX21 is regulated by acetylation. Acetylation by CBP inhibits DDX21 activity, while deacetylation by SIRT7 augments helicase activity and overcomes R-loop-mediated stalling of RNA polymerases.|acetylation of K18, K137, and K600 impairs the helicase activity of DDX21. |
|
| Publications: |
3 |
| + |
CREBBP | up-regulates activity 
acetylation
|
KLF1 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251826 |
Lys288 |
CAHPGCGkSYTKSSH |
Homo sapiens |
|
| pmid |
sentence |
| 11259590 |
EKLF residues acetylated by CREB binding protein (CBP) in vitro map to Lys-288 in its transactivation domain and Lys-302 in its zinc finger domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates activity
acetylation
|
STAT2 |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217891 |
Lys390 |
QKTLTPEkGQSQGLI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17923090 |
STAT2 is another important component of ISGF3 complex, and its acetylation was similar to IFNaR2 and IRF9 acetylation in many respects: CBP downregulation largely abolished STAT2 acetylation induction by IFNa (Figure 6A), and CBP was more potent than transferases tested in catalyzing STAT2 acetylation (Figure 6B). [...] Figure 6 (I) STAT2-K390R substitution has reduced activity in ISGF3 complex formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates activity
acetylation
|
IFNAR2 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217783 |
Lys399 |
SGPCERRkSPLQDPF |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17923090 |
By binding to IFNalphaR2 within the region where two adjacent proline boxes bear phospho-Ser364 and phospho-Ser384, CBP acetylates IFNalphaR2 on Lys399, which in turn serves as the docking site for interferon regulatory factor 9 (IRF9)RF9 interacts with the acetyl-Lys399 motif by means of its IRF homology2 (IH2) domain, leading to formation of the ISGF3 complex that includes IRF9, STAT1, and STAT2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates activity
acetylation
|
IRF9 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217787 |
Lys81 |
TGGPAVWkTRLRCAL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17923090 |
CBP was also the most effective one among the acetyltransferases tested for catalyzing IRF9 acetylation in 293T cells. [²] Figure 5 (F) K81 acetylation is required for IRF9 dimerization between the N-terminal 1-118 and the C-terminal 340-393 regions. In the left panel, Myc-DBD (1- 118) of IRF9 was cotransfected with 118-393, 118-339, or 1-393 (FL) of IRF9 in 293T cells. Anti-IRF9 (C-terminal region) precipitates were analyzed with anti-Myc or anti-IRF9. Anti-IRF9 precipitates, prepared from 293T cells cotransfected with the C-terminal fragment 118-393 of IRF9 and Myctagged DBD of different forms, were analyzed with anti-Myc or anti-IRF9 (right panel). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
CHUK | up-regulates
phosphorylation, binding
|
CREBBP |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154329 |
Ser1382 |
MKSRFVDsGEMSESF |
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 17434128 |
Phosphorylation of cbp by ikkalpha promotes cell growth by switching the binding preference of cbp from p53 to nf-kappabhere, we show that ikkalpha phosphorylates cbp at serine 1382 and serine 1386 and consequently increases cbp's hat and transcriptional activities |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154333 |
Ser1386 |
FVDSGEMsESFPYRT |
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 17434128 |
Phosphorylation of cbp by ikkalpha promotes cell growth by switching the binding preference of cbp from p53 to nf-kappabhere, we show that ikkalpha phosphorylates cbp at serine 1382 and serine 1386 and consequently increases cbp's hat and transcriptional activities |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12789342 |
Ikk-alpha interacts with creb-binding protein and in conjunction with rel a is recruited to nf-kappab-responsive promoters and mediates the cytokine-induced phosphorylation and subsequent acetylation of specific residues in histone h3. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CAMK4 | up-regulates activity
phosphorylation
|
CREBBP |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250710 |
Ser302 |
PQLASKQsMVNSLPT |
|
Neuron |
| pmid |
sentence |
| 11970865 |
Ser301 of CBP was identified as a major target of CaMKIV phosphorylation in vitro and in vivo. CaM kinase inhibitors attenuated phosphorylation at Ser301 and blocked CBP-dependent transcription. Additionally, mutation of Ser301 impaired NMDA- and CaMKIV-stimulated transcription. These findings demonstrate that activity-induced CaMKIV signaling contributes to CREB/CBP-dependent transcription by phosphorylating CBP at Ser301. |
|
| Publications: |
1 |
| Pathways: | Thyroid Hormone Metabolism |
| + |
PRKCD |
phosphorylation
|
CREBBP |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249104 |
Ser437 |
CLPLKNAsDKRNQQT |
|
|
| pmid |
sentence |
| 11463380 |
This study demonstrates that transcriptional control of mitogen-responsive genes by AP-1 and Pit-1 response elements involves direct phosphorylation of CBP and that growth factordependent phosphorylation of CBP within the GF box is indispensable for signaling via these sites. |
|
| Publications: |
1 |
| + |
EID1 | down-regulates activity
binding
|
CREBBP |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253380 |
|
|
|
|
| pmid |
sentence |
| 11073989 |
Here, we show that EID-1 is a potent inhibitor of differentiation and link this activity to its ability to inhibit p300 (and the highly related molecule, CREB-binding protein, or CBP) histone acetylation activity. |
|
| Publications: |
1 |
| + |
CREBBP | form complex 
binding
|
P300/PCAF |
0.635 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170262 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21131905 |
Histone acetyltransferases (hats) gcn5 and pcaf (gcn5/pcaf) and cbp and p300 (cbp/p300) are transcription co-activators. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates activity
binding
|
MYB |
0.794 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240994 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 8654374 |
the nuclear co-activator CREB binding protein (CBP). This protein interacts directly with both c-Myb and v-Myb and potentiates Myb-specific transcription |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CREBBP | up-regulates activity
binding
|
LHX3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267206 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10931853 |
Transcription of pituitary alpha-glycoprotein hormone subunit (alpha-GSU) and thyrotropin beta subunit (TSH-beta) genes is stimulated by thyrotropin-releasing hormone (TRH). P-Lim and CBP Act Synergistically in TRH Stimulation of the Human α-GSU Promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
SS18L1 | up-regulates
relocalization
|
CREBBP |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129926 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 15488321 |
The calcium-responsive transactivator recruits creb binding protein to nuclear bodies. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | form complex
binding
|
CBP/p300 |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110559 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11559745 |
P300/cbp proteins: hats for transcriptional bridges and scaffolds |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates quantity by expression 
transcriptional regulation
|
INSM1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253813 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 17300785 |
The ngn3/E47 heterodimer selectively binds and activates the E-box3 of the INSM1 promoter. The endogenous ngn3 and CREB-binding protein (CBP) co-activator occupy the INSM1 promoter, resulting in hyper-acetylation of histone H3/H4 chromatin in a human neuroblastoma cell line, IMR-32. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KHDRBS1 | down-regulates activity
binding
|
CREBBP |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266202 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 12496368 |
These results suggest that Sam68 and CBP interact in vivo in a manner dependent on the FXE/DXXXL motif. Sam68 Represses CBP-dependent Transcriptional Activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates
binding
|
CREBBP |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166170 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20551513 |
Mechanistic analysis revealed that the tak1-mkk3/6-p38 mapk axis phosphory-lated runx2, promoting its association with the coac-tivator creb-binding protein (cbp), which is re-quired to regulate osteoblast genetic programs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates quantity by expression
transcriptional regulation
|
ALOX15 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254093 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 12517954 |
In A549 cells activation of 15-LOX by IL-4 required the coactivation of histone acetyltransferases CREB-binding protein/p300 and led to a sizable production of 15(S)-HETE |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates activity
binding
|
MYBL1 |
0.491 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240984 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 9210395 |
CBP co-operates functionally with A-Myb |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CREBBP | up-regulates
acetylation
|
RELA |
0.871 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143396 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16382138 |
Rela is also acetylated at several sites by p300 and cbp |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates
binding
|
CREBBP |
0.871 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-66953 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10207072 |
Both p53 and rela(p65) interact with the transcriptional coactivator proteins p300 and creb-binding protein (cbp), and we demonstrate that these results are consistent with competition for a limiting pool of p300/cbp complexes in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates
acetylation
|
MYOD1 |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81050 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10944526 |
Our results provide direct evidence that myod acetylation functionally activates the protein and show that both pcaf and cbp/p300 are candidate enzymes for myod acetylation in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
PRKCA | down-regulates
phosphorylation
|
CREBBP |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166368 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
The action of metformin was shown to be mediated through activation of apkc?/?, Which phosphorylates cbp at ser436, and disrupts the transcriptionally active creb-cbp-crtc2 complex, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
CREBBP | up-regulates
binding
|
CREB1 |
0.939 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62260 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9829964 |
When overexpressed in serum-stimulated cells, akt/pkb potently induced ser-133 phosphorylation of creb and promoted recruitment of cbp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
CREBBP | up-regulates activity
acetylation
|
TP53 |
0.908 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261495 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25545885 |
C-terminal acetylation of p53 by p300/CBP and PCAF promotes an open conformation of p53 by preventing the occlusion of the DNA binding domain by the C-terminal tail. This enhances p53 transcriptional activity, leading to growth arrest and/or apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates
binding
|
MEF2C |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The cofactors grip-1, cbp/p300 and pcaf have hat activity and function as co-activators for mef-2c during myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates
binding
|
CSK |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77139 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10801129 |
Here we present cbp--a transmembrane phosphoprotein that is ubiquitously expressed and binds specifically to the sh2 domain of csk. Cbp is involved in the membrane localization of csk and in the csk-mediated inhibition of c-src. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates activity
binding
|
POU1F1 |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267204 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10931853 |
We and others have recently shown that CBP can constitutively bind to Pit-1 and synergistically activate transcription of promoters containing Pit-1 DNA-binding sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| Pathways: | Thyroid Hormone Metabolism |
3.0
CREBBP
- 
- 