Summary

Name CREBBP
Full Name CREB-binding protein
Synonyms CBP_HUMAN | CBP
Primary ID Q92793
Links - -
Type protein
Relations 25
Function Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png acetylation KLF1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png acetylation STAT2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png acetylation IFNAR2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png acetylation IRF9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation, binding CREBBP 0.43
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CREBBP 0.14
Publications: 1
+ img/unknown.png phosphorylation CREBBP 0.14
Publications: 1
+ up-regulates img/direct-activation.png binding CREBBP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CREBBP 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CREBBP 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CSK 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CREBBP 0.14
Publications: 1
+ up-regulates activity img/direct-activation.png binding MYBL1 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation CREBBP 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation INSM1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png acetylation RELA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation MYOD1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png binding MYB 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding MEF2C 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding P300/PCAF 0.14
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CBP/p300 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CREB1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALOX15 0.14
Publications: 1 Organism: Homo Sapiens