Summary

Name TGFB1
Full Name Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide
Synonyms TGF-beta-1 | TGFB
Primary ID P01137
Links - -
Type protein
Relations 71
Pathways Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, EBV infection, FAP: TGF beta, myCAF signaling in PDAC, Macrophage: Polarization and myogenesis, Macrophage: TGF beta, Osteoblast: TGF beta, P38 Signaling, SARS-CoV MAPK PERTURBATION, Thyroid cancer, TGF-beta Signaling, Thyroid Hormone Metabolism, T-Lymphocyte: TGF beta
Function Transforming growth factor beta-1 proprotein

Viewer

Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RUNX2 0.352
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates img/indirect_inhibition.png MYOG 0.261
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ENG 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LPL 0.268
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/indirect-activation.png TGFB1 0.7
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ANKH 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CDK2 0.286
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png binding TGFB1 0.623
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDK4 0.286
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates img/indirect-activation.png Angiogenesis 0.7
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TGFB1 0.313
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TGFBR2 0.847
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, Thyroid cancer, TGF-beta Signaling, TGFb in cancer
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.261
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RNF111 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SFTPB 0.286
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.266
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, Thyroid Hormone Metabolism
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation TSHB 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer, Thyroid Hormone Metabolism
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DNAH10 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TFAP4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGA2 0.29
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TGFB1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, EBV infection, Cell cycle: G1/S phase transition, P38 Signaling, SARS-CoV MAPK PERTURBATION, Thyroid cancer, TGF-beta Signaling, Thyroid Hormone Metabolism, TGFb in cancer
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PAX6 0.278
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TGFBR1 0.84
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Cell cycle: G1/S phase transition, P38 Signaling, SARS-CoV MAPK PERTURBATION, Thyroid cancer, TGF-beta Signaling, Thyroid Hormone Metabolism, TGFb in cancer
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation OMD 0.272
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TGFBR1 0.84
Publications: 3 Organism: Homo Sapiens
Pathways:Adipogenesis, COVID-19 Causal Network, Colorectal Carcinoma, Cell cycle: G1/S phase transition, P38 Signaling, SARS-CoV MAPK PERTURBATION, Thyroid cancer, TGF-beta Signaling, Thyroid Hormone Metabolism, TGFb in cancer
+ up-regulates quantity img/direct-activation.png binding TGFB1 0.504
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COL1A2 0.405
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TGFB1 0.524
Publications: 1 Organism: Mus Musculus
Pathways:TGF-beta Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SALL2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBA1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png CyclinE/CDK2 0.279
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ENPP1 0.271
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png SHC1 0.431
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN2B 0.286
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, TGF-beta Signaling, TGFb in cancer
+ up-regulates img/direct-activation.png Activated PSC 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Pancreas
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ACTA2 0.431
Publications: 1 Organism: Homo Sapiens
Tissue: Fibroblast
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SLC5A5 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer, Thyroid Hormone Metabolism
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ACTA2 0.431
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage TGFB1 0.572
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png relocalization TGFB1 0.252
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Thyroid cancer
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation COL1A1 0.499
Publications: 1 Organism: Homo Sapiens
Tissue: Pancreas
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TGFB1 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png TGFB1 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Pancreas
+ down-regulates img/indirect_inhibition.png SKP2 0.261
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MEF2D 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png NfKb-p65/p50 0.38
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection
+ up-regulates quantity by expression img/indirect-activation.png CDKN1B 0.294
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOCD 0.271
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CCNA2 0.289
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PIK3CG 0.278
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png TGFB1 0.54
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TGFB1 0.2
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TGFB1 0.301
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PPP2R2A 0.357
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation TGFB1 0.612
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBB 0.265
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TGFB1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BGLAP 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PAX8 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates img/direct-activation.png binding TGFBR2 0.847
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Thyroid cancer, TGF-beta Signaling, TGFb in cancer
+ up-regulates img/direct-activation.png cleavage TGFB1 0.611
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TAGLN 0.345
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ITGA3 0.359
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png TGFB1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC20A1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LPP 0.333
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation KRT1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COL4A1 0.376
Publications: 1 Organism: Homo Sapiens