Summary

Name AR
Full Name Androgen receptor
Synonyms Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4 | DHTR, NR3C4
Primary ID P10275
Links - -
Type protein
Relations 108
Pathways Prostate Cancer
Inhibitors perfluorodecanoic acid; perfluorononanoic acid; nilutamide; flutamide; cyproterone acetate; bisphenol A; enzalutamide; 4,4'-sulfonyldiphenol; perfluorooctanoic acid; perfluorohexanesulfonic acid; perfluorooctane-1-sulfonic acid; bisphenol F; N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation AR 0.59
Publications: 2 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation AR 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates img/direct_inhibition.png phosphorylation AR 0.59
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AR 0.384
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation AR 0.511
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation AR 0.597
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation AR 0.514
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AR 0.378
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AR 0.32
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AR 0.2
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Prostate Cancer
+ up-regulates img/direct-activation.png phosphorylation AR 0.374
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AR 0.534
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AR 0.297
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png dephosphorylation AR 0.584
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates img/direct-activation.png phosphorylation AR 0.26
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AR 0.549
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AR 0.76
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AR 0.901
Publications: 2 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ARG1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Differentiation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates activity img/direct-activation.png chemical activation AR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TMPRSS2 0.58
Publications: 3 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates activity img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation AR 0.506
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates activity img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding AR 0.398
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation AR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AR 0.719
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CTNNB1 0.729
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation UBE2C 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates activity img/direct-activation.png binding AR 0.702
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AR 0.463
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AR 0.762
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AR 0.859
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AR 0.526
Publications: 1 Organism: Homo Sapiens
Tissue: Prostate Gland
+ up-regulates img/direct-activation.png binding AR 0.395
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ARG2 0.263
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SEPTIN7 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BTG1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NRAS 0.283
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AR 0.586
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AR 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates activity img/direct-activation.png binding AR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AR 0.544
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ZBTB46 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NAT1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KLK3 0.822
Publications: 1
+ up-regulates img/direct-activation.png binding AR 0.321
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BTG2 0.378
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png chemical activation AR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AR 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AR 0.412
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CLK3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SERPINB5 0.404
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation AR 0.508
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SCN9A 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png ubiquitination AR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation AR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.358
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AR 0.481
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Survival 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates img/indirect_inhibition.png AR 0.2
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AKR1C3 0.452
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NR5A1 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation AR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation AR 0.766
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CRH 0.306
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AR 0.417
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NKX3-1 0.506
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates activity img/direct-activation.png phosphorylation AR 0.384
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation AR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation WEE1 0.261
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AR 0.373
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding AR 0.417
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation AR 0.331
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CYP7B1 0.29
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png acetylation AR 0.565
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation AR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AR 0.497
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation UCN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation AR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AR 0.452
Publications: 1
+ up-regulates activity img/direct-activation.png binding AR 0.708
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png binding NR3C1 0.543
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AR 0.543
Publications: 1 Organism: Homo Sapiens