| + |
MAPK7 | up-regulates 
phosphorylation
|
MEF2C |
0.763 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53545 |
Ser387 |
LSLPSTQsLNIKSEP |
Homo sapiens |
|
| pmid |
sentence |
| 9384584 |
Bmk1 dramatically enhances the transactivation activity of mef2c by phosphorylating a serine residue at amino acid position 387 in this transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
MEF2C |
0.694 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62788 |
Ser387 |
LSLPSTQsLNIKSEP |
Homo sapiens |
|
| pmid |
sentence |
| 9858528 |
Our studies showed that p38 specifically phosphorylates serine 387 and threonines 293 and 300 within the mef2c transactivation domain |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62792 |
Thr293 |
QSAQSLAtPVVSVAT |
Homo sapiens |
|
| pmid |
sentence |
| 9858528 |
Our studies showed that p38 specifically phosphorylates serine 387 and threonines 293 and 300 within the mef2c transactivation domain |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47136 |
Thr293 |
QSAQSLAtPVVSVAT |
Homo sapiens |
|
| pmid |
sentence |
| 9069290 |
We found that in monocytic cells, lps increases the transactivation activity of mef2c through p38-catalysed phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62796 |
Thr300 |
TPVVSVAtPTLPGQG |
Homo sapiens |
|
| pmid |
sentence |
| 9858528 |
Our studies showed that p38 specifically phosphorylates serine 387 and threonines 293 and 300 within the mef2c transactivation domain |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
As a permissive environment is created at these loci, p38 further stimulates gene expression through the phosphorylation of additional myogenic transcription factors, including mef2c and e47. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis |
| + |
CyclinB/CDK1 | down-regulates activity 
phosphorylation
|
MEF2C |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250719 |
Ser396 |
NIKSEPVsPPRDRTT |
|
10T1/2 Cell |
| pmid |
sentence |
| 16478538 |
Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity. | Intriguingly, we show that phosphorylation of S396 in MEF2C, a residue in close proximity to the major sumoylation site (K391) and known to be phosphorylated in vivo, enhances sumoylation of delta- N2-MEF2C in vitro. The S396A mutation reduces sumoylation of MEF2C in vivo and enhances the transcription activity of MEF2C in reporter assays. | CDK1/Cyclin B1 phosphorylated GST-MEF2C-ΔN2-WT to a greater extent than the MEF2C-ΔN2-S396A mutant, suggesting that Cdk1/Cyclin B1 can phosphorylate MEF2C at S396. |
|
| Publications: |
1 |
| + |
CSNK2A1 | up-regulates activity
phosphorylation
|
MEF2C |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250914 |
Ser59 |
NKLFQYAsTDMDKVL |
in vitro |
|
| pmid |
sentence |
| 8663403 |
We show that serine 59 located between the MADS and MEF2 domains of MEF2C is phosphorylated in vivo and can be phosphorylated in vitro by casein kinase-II (CKII). Phosphorylation of this site enhanced the DNA binding and transcriptional activity of MEF2C by increasing its DNA binding activity 5-fold. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MYLK2 | up-regulates activity
phosphorylation
|
MEF2C |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238118 |
Thr80 |
NEPHESRtNSDIVET |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21556048 |
Here, we show that phosphorylation of MEF2C on T(80) by skeletal myosin light chain kinase (skMLCK) enhances skeletal and not cardiac myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYLK3 | up-regulates activity
phosphorylation
|
MEF2C |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264565 |
Thr80 |
NEPHESRtNSDIVET |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21556048 |
Here, we show that phosphorylation of MEF2C on T(80) by skeletal myosin light chain kinase (skMLCK) enhances skeletal and not cardiac myogenesis.|Here, we show that skMLCK directly phosphorylates MEF2C, leading to p300/PCAF recruitment, increased acetylation of skeletal muscle-specific genes, and enhanced skeletal myogenesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CABIN1 | down-regulates 
|
MEF2C |
0.668 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151205 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17172641 |
Thus, cabin1 recruits chromatin-modifying enzymes, both histone deacetylases and a histone methyltransferase, to repress mef2 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBP/p300 | up-regulates
binding
|
MEF2C |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83840 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
Cbp/p300 and pcaf are coactivators for myod and mef-2c during myogenic commitment and differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HABP4 | down-regulates activity
binding
|
MEF2C |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238283 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 15862299 |
MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
HDAC4 | down-regulates
binding
|
MEF2C |
0.711 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-76234 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10737771 |
We discovered that mef2 interacts with histone deacetylases (hdacs) 4 and 5, resulting in repression of the transcriptional activity of mef2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | IGF and Myogenesis |
| + |
AKT1 | up-regulates activity 
|
MEF2C |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79335 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10896679 |
Two candidates that may function as mediators of pi3-k in the phosphorylation of mef2 proteins are pkb and big map kinase 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | IGF and Myogenesis, P38 Signaling and Myogenesis |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
CDKL5 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254031 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20513142 |
Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression|In these patients we found diminished MECP2 and CDKL5 expression in vivo, and transcriptional reporter assays indicated that MEF2C mutations diminish synergistic transactivation of E-box promoters including that of MECP2 and CDKL5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
HDAC9 | down-regulates
binding
|
MEF2C |
0.629 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235642 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 15546868 |
Mirk activated mef2 not through direct phosphorylation of mef2 but by phosphorylation of its inhibitors, the class ii histone deacetylases (hdacs). Mef2 is sequestered by class ii hdacs such as hdac5 and mef2-interacting transcriptional repressor (mitr). Mirk antagonized the inhibition of mef2c by mitr, whereas kinase-inactive mirk was ineffective. Mirk phosphorylates class ii hdacs at a conserved site within the nuclear localization region, reducing their nuclear accumulation in a dose-dependent and kinase-dependent manner |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
STAT5A | down-regulates quantity by repression
transcriptional regulation
|
MEF2C |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254207 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21261500 |
STAT5 binds directly to the promoter region and potently mediates repression of MEF2C, probably via HDAC recruitment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIPK2 | down-regulates activity
phosphorylation
|
MEF2C |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279192 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23620283 |
HIPK2 associates with the MEF2C\u2013HDAC4 complex and phosphorylates MEF2C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
CyclinD/CDK4 | down-regulates
binding
|
MEF2C |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216963 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
In contrast to cdk2, cyclin d/cdk4 blocks myod activity through an as yet unclear mechanism that may involve direct binding. Cyclin d/cdk4 can also block the activity of myogenin and all mef2 isoforms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
NKX2-5 | up-regulates quantity by expression
transcriptional regulation
|
MEF2C |
0.736 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253656 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21261500 |
Taken together, our results indicate that the expression of MEF2C in T-ALL cells is principally deregulated via activating leukemic transcription factors GFI1B or NKX2-5 and by escaping inhibitory developmental STAT5 signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
CTNNA3 |
0.241 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265491 |
|
|
Homo sapiens |
Cardiac Muscle Fiber |
| pmid |
sentence |
| 21598020 |
GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
MEF2C |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264680 |
|
|
Mus musculus |
Hypothalamus |
| pmid |
sentence |
| 18511691 |
MeCP2 binds to the promoter region of six target genes. ChIP with anti-MeCP2 antibody shows that MeCP2 binds to the promoter regions of activated targets Sst, Oprk1, Gamt, and Gprin1, and repressed targets Mef2c and A2bp1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
MYCN | down-regulates quantity by repression
transcriptional regulation
|
MEF2C |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254214 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 21261500 |
HOXA9/HOXA10 activated expression of NMYC which in turn mediated MEF2C repression, indicating an indirect mode of regulation via NMYC interactor (NMI) and STAT5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK4 | down-regulates
binding,
|
MEF2C |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176518 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
In contrast to cdk2, cyclin d/cdk4 blocks myod activity through an as yet unclear mechanism that may involve direct binding. Cyclin d/cdk4 can also block the activity of myogenin and all mef2 isoforms. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176521 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Not much is known about how this occurs, but inhibition of mef2c by cdk4 prevents the association of mef2 with its transcriptional coactivator, glucocorticoid receptor-interacting protein 1 (grip1). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GRIP1 | up-regulates
binding
|
MEF2C |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83883 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The cofactors grip-1, cbp/p300 and pcaf have hat activity and function as co-activators for mef-2c during myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Calcineurin | up-regulates
|
MEF2C |
0.388 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252309 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
MAML1 | up-regulates
binding
|
MEF2C |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144913 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16510869 |
Unexpectedly, however, emerging evidence implicate maml proteins as exciting key transcriptional co-activators in other signal transduction pathways including: muscle differentiation and myopathies (mef2c), tumor suppressor pathway (p53) and colon carcinoma survival (beta-catenin). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP3CC | up-regulates
|
MEF2C |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83740 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
GFI1B | up-regulates quantity by expression
transcriptional regulation
|
MEF2C |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254206 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 21261500 |
Here, we analyzed the MEF2C 5'-region, thus identifying potential regulatory binding sites for GFI1B, basic helix-loop-helix proteins, STAT5, and HOXA9/HOXA10. Chromatin immunoprecipitation and overexpression analyses demonstrated direct activation by GFI1B and LYL1 and inhibition by STAT5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXJ3 | up-regulates quantity by expression
transcriptional regulation
|
MEF2C |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261606 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 19914232 |
Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CREBBP | up-regulates
binding
|
MEF2C |
0.688 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The cofactors grip-1, cbp/p300 and pcaf have hat activity and function as co-activators for mef-2c during myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HEY1 | down-regulates quantity by repression
transcriptional regulation
|
MEF2C |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235819 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19917614 |
Our results indicate instead that hey1 is recruited to the promoter regions of myogenin and mef2c, two genes whose induction is critical for myogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling and Myogenesis |
| + |
TAL1 | up-regulates quantity by expression
transcriptional regulation
|
MEF2C |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254209 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 21261500 |
TAL1 and LYL1 are two leukemic members of the bHLH family of transcription factors. TAL1 and LYL1 activate expression of MEF2C |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
MYH2 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238718 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15728583 |
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
MYH1 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238754 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15728583 |
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | IGF and Myogenesis |
| + |
MEF2C | up-regulates activity
binding
|
MYOD1 |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-54089 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9418854 |
Myod-e protein heterodimers interact with mef2 proteins to synergistically activate myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis |
| + |
MEF2C | up-regulates
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265800 |
|
|
in vitro |
|
| pmid |
sentence |
| 23001426 |
In brain, MEF2C is essential for early neurogenesis, neuronal migration, and differentiation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Rett syndrome |
| + |
PPP3CA | up-regulates
|
MEF2C |
0.504 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84035 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
LYL1 | up-regulates quantity by expression
transcriptional regulation
|
MEF2C |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254208 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21261500 |
TAL1 and LYL1 are two leukemic members of the bHLH family of transcription factors. TAL1 and LYL1 activate expression of MEF2C |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXA10 | down-regulates quantity by repression
transcriptional regulation
|
MEF2C |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254212 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 21261500 |
Overexpression of HOXA9 or HOXA10 in JURKAT cells by lentiviral transduction resulted in decreased expression of MEF2C, indicating repression by these homeodomain proteins. HOXA9/10 inhibits expression of MEF2C via NMYC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK11 | up-regulates activity
phosphorylation
|
MEF2C |
0.535 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280025 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10330143 |
In this study, we demonstrate that among the different Mitogen-activated protein kinases, the MADS-box transcription factors MEF2A and MEF2C are preferentially phosphorylated and activated by the p38 subfamily members p38alpha and p38beta2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
MYH10 |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238769 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15728583 |
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
MEF2C | up-regulates
|
Skeletal_muscle_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219368 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10082551 |
During embryogenesis, the MEF2 genes are expressed throughout developing skeletal and cardiac muscle lineages, as well as in the nervous system (19, 42, 65, 68).MEF2C is the first member of the family to be expressed in developing muscle cell lineages, with transcripts appearing in precardiac cells by about embryonic day 7.75 and in skeletal muscle precursor cells within the myotome of the developing somites by embryonic day 8.5. Soon thereafter, the other MEF2 genes are expressed in overlapping patterns (19). After birth, the expression of MEF2A, -B, and -Dbecomes ubiquitous, whereas the expression of MEF2C becomes restricted to skeletal muscle, brain, and spleen |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis |
| + |
PPP3CB | up-regulates
|
MEF2C |
0.462 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84044 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
DYRK1B | up-regulates
|
MEF2C |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235816 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 15546868 |
Mirk activated mef2 not through direct phosphorylation of mef2 but by phosphorylation of its inhibitors, the class ii histone deacetylases (hdacs). Mef2 is sequestered by class ii hdacs such as hdac5 and mef2-interacting transcriptional repressor (mitr). Mirk antagonized the inhibition of mef2c by mitr, whereas kinase-inactive mirk was ineffective. Mirk phosphorylates class ii hdacs at a conserved site within the nuclear localization region, reducing their nuclear accumulation in a dose-dependent and kinase-dependent manner |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
EP300 | up-regulates
binding
|
MEF2C |
0.741 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232159 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11796223 |
Once released from associated repressors, MEF2 is bound by the p300 coactivator, which possesses histone acetyltransferase activity. Thus, the net result of CaMK signaling to MEF2 complexes is increased histone acetylation (Ac), which relaxes chromatin and stimulates MEF2 target gene transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83846 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The cofactors grip-1, cbp/p300 and pcaf have hat activity and function as co-activators for mef-2c during myogenesis. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
JUN |
0.616 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47139 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9069290 |
One consequence of mef2c activation is increased c-jun gene transcription. Our results show that p38 may influence host defence and inflammation by maintaining the balance of c-jun protein consumed during infection |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
α-Catenin |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265816 |
|
|
Homo sapiens |
Cardiac Muscle Fiber |
| pmid |
sentence |
| 21598020 |
GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
CPT1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254583 |
|
|
Mus musculus |
Adenocarcinoma Cell Line |
| pmid |
sentence |
| 15356291 |
Mutation analysis indicated that the MEF2 site contributed to the activation of the CPT1beta promoter by PPAR in C2C12 cells. The reporter construct containing the PPRE and the MEF2C site was synergistically activated by co-expression of PPAR, retinoid X receptor (RXR) and MEF2C in non-muscle cells. Moreover, protein-binding assays demonstrated that MEF2C and PPAR specifically bound to one another in vitro. Also for the synergistic activation of the CPT1beta gene promoter by MEF2C and PPARalpha-RXRalpha, a precise arrangement of its binding sites was essential. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HOXA9 | down-regulates quantity by repression
transcriptional regulation
|
MEF2C |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254211 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 21261500 |
Overexpression of HOXA9 or HOXA10 in JURKAT cells by lentiviral transduction resulted in decreased expression of MEF2C, indicating repression by these homeodomain proteins. HOXA9/10 inhibits expression of MEF2C via NMYC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PP2B | up-regulates
|
MEF2C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269993 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The ca2+ dependent phosphatase calcineurin induces cardiac and skeletal muscle hypertrophy by a process that involves nf-at nuclear translocation, and activation of mef2c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
KAT2B | up-regulates
binding
|
MEF2C |
0.57 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The cofactors grip-1, cbp/p300 and pcaf have hat activity and function as co-activators for mef-2c during myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
MECP2 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254025 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20513142 |
Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression|In these patients we found diminished MECP2 and CDKL5 expression in vivo, and transcriptional reporter assays indicated that MEF2C mutations diminish synergistic transactivation of E-box promoters including that of MECP2 and CDKL5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rett syndrome |
| + |
MEF2C | up-regulates quantity by expression
transcriptional regulation
|
MYF6 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238652 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 7739551 |
Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | IGF and Myogenesis |
| + |
HDAC5 | down-regulates
binding
|
MEF2C |
0.694 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84026 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The histone deacetylase hdac-5, upon dephosphorylation and translocation to the nucleus, directly inactivates mef2, preventing myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
4.0
MEF2C
- 
- 