Summary

Name WNT1
Full Name Proto-oncogene Wnt-1
Synonyms Proto-oncogene Int-1 homolog | INT1
Primary ID P04628
Links - -
Type protein
Relations 26
Pathways Colorectal Carcinoma, GPCR_CRC, WNT Signaling, WNT Signaling and Myogenesis
Function Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646).

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Relations

Regulator Mechanism target score
+ up-regulates img/indirect-activation.png CTNNB1 0.744
Publications: 1 Organism: Rattus Norvegicus
Pathways:Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png MYF5 0.339
Publications: 2 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding FZD3 0.626
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.828
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation WNT1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png PRKACA 0.268
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding FZD1 0.7
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Tissue: Muscle, Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png binding WNT1 0.784
Publications: 2 Organism: Homo Sapiens
Pathways:WNT Signaling
+ up-regulates img/direct-activation.png binding RYK 0.707
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD8 0.724
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png WNT1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding Frizzled 0.766
Publications: 2 Organism: , Mus Musculus
Tissue: Muscle
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/indirect_inhibition.png WNT1 0.278
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation WNT1 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation WNT1 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation WNT1 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation WNT1 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FZD6 0.691
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding LRP5 0.788
Publications: 2 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding WNT1 0.522
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney