| + |
MAPK3 | up-regulates activity 
phosphorylation
|
SREBF1 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80096 |
Ser117 |
YPSMPAFsPGPGIKE |
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 10915800 |
Map kinases erk1/2 phosphorylate sterol regulatory element-binding protein (srebp)-1a at serine 117 in vitro. mutation of serine 117 to alanine abolished erk2-mediated phosphorylation in vitro and the map kinase-related transcriptional activation of srebp-1a by insulin and platelet-derived growth factor in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates
phosphorylation
|
SREBF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244754 |
Ser117 |
YPSMPAFsPGPGIKE |
Homo sapiens |
|
| pmid |
sentence |
| 10915800 |
Map kinases erk1/2 phosphorylate sterol regulatory element-binding protein (srebp)-1a at serine 117 in vitro. mutation of serine 117 to alanine abolished erk2-mediated phosphorylation in vitro and the map kinase-related transcriptional activation of srebp-1a by insulin and platelet-derived growth factor in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Insulin Signaling, MTOR Signaling |
| + |
MAPK1 | up-regulates
phosphorylation
|
SREBF1 |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80092 |
Ser117 |
YPSMPAFsPGPGIKE |
Homo sapiens |
|
| pmid |
sentence |
| 10915800 |
Map kinases erk1/2 phosphorylate sterol regulatory element-binding protein (srebp)-1a at serine 117 in vitro. mutation of serine 117 to alanine abolished erk2-mediated phosphorylation in vitro and the map kinase-related transcriptional activation of srebp-1a by insulin and platelet-derived growth factor in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates 
phosphorylation
|
SREBF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143392 |
Ser338 |
IEKRYRSsINDKIIE |
Homo sapiens |
|
| pmid |
sentence |
| 16381800 |
Sterol regulatory element-binding protein 1 is negatively modulated by pka phosphorylation. ser338 of srebp-1a and ser314 of srebp-1c are pka phosphorylation sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA2 | down-regulates
phosphorylation
|
SREBF1 |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173031 |
Ser396 |
TAVHKSKsLKDLVSA |
Homo sapiens |
|
| pmid |
sentence |
| 21459323 |
Here we demonstrate that ampk interacts with and directly phosphorylates sterol regulatory element binding proteins (srebp-1c and -2). Ser372 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | down-regulates
phosphorylation
|
SREBF1 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216533 |
Ser396 |
TAVHKSKsLKDLVSA |
Homo sapiens |
|
| pmid |
sentence |
| 21459323 |
Here we demonstrate that ampk interacts with and directly phosphorylates sterol regulatory element binding proteins (srebp-1c and -2). Ser372 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216564 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21892142 |
Ampk was recently found to phosphorylate a conserved serine near the cleavage site within srebp1, suppressing its activation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock, MTOR Signaling |
| + |
GSK3B | down-regulates quantity by destabilization
phosphorylation
|
SREBF1 |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236030 |
Ser430 |
DTLTPPPsDAGSPFQ |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19126544 |
Importantly, we demonstrate that the mature form of endogenous SREBP1 is phosphorylated on Ser-434. Glycogen synthase kinase-3 phosphorylates Ser-434, and the phosphorylation of this residue is attenuated in response to insulin signaling. Interestingly, phosphorylation of Ser-434 promotes the glycogen synthase kinase-3-dependent phosphorylation of Thr-426 and Ser-430 and destabilizes SREBP1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236645 |
Ser430 |
DTLTPPPsDAGSPFQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16825193 |
The transcription factor SREBP1 is degraded by the ubiquitin-proteasome system following phosphorylation of Thr426 and Ser430 in its phosphodegron. We now demonstrate that the glycogen synthase kinase (GSK)-3beta-dependent phosphorylation of these residues in SREBP1 is enhanced in response to specific DNA binding |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235797 |
Ser434 |
PPPSDAGsPFQSSPL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19126544 |
Importantly, we demonstrate that the mature form of endogenous SREBP1 is phosphorylated on Ser-434. Glycogen synthase kinase-3 phosphorylates Ser-434, and the phosphorylation of this residue is attenuated in response to insulin signaling. Interestingly, phosphorylation of Ser-434 promotes the glycogen synthase kinase-3-dependent phosphorylation of Thr-426 and Ser-430 and destabilizes SREBP1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236649 |
Thr426 |
TEVEDTLtPPPSDAG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16825193 |
The transcription factor SREBP1 is degraded by the ubiquitin-proteasome system following phosphorylation of Thr426 and Ser430 in its phosphodegron. We now demonstrate that the glycogen synthase kinase (GSK)-3beta-dependent phosphorylation of these residues in SREBP1 is enhanced in response to specific DNA binding |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236667 |
Thr426 |
TEVEDTLtPPPSDAG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19126544 |
Importantly, we demonstrate that the mature form of endogenous SREBP1 is phosphorylated on Ser-434. Glycogen synthase kinase-3 phosphorylates Ser-434, and the phosphorylation of this residue is attenuated in response to insulin signaling. Interestingly, phosphorylation of Ser-434 promotes the glycogen synthase kinase-3-dependent phosphorylation of Thr-426 and Ser-430 and destabilizes SREBP1. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| Pathways: | Insulin Signaling, MTOR Signaling |
| + |
CDK1 | up-regulates
phosphorylation
|
SREBF1 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148354 |
Ser439 |
AGSPFQSsPLSLGSR |
Homo sapiens |
|
| pmid |
sentence |
| 16880739 |
Cdk1/cyclin b-mediated phosphorylation stabilizes srebp1 during mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinB/CDK1 | up-regulates
phosphorylation
|
SREBF1 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216821 |
Ser439 |
AGSPFQSsPLSLGSR |
Homo sapiens |
|
| pmid |
sentence |
| 16880739 |
Cdk1/cyclin b-mediated phosphorylation stabilizes srebp1 during mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK1 | up-regulates activity
phosphorylation
|
SREBF1 |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279382 |
Ser467 |
DSPVFEDsKAKPEQR |
Homo sapiens |
|
| pmid |
sentence |
| 27579997 |
As illustrated in , the turnover of nuclear SREBP1a was attenuated in the presence of Plk1, confirming that Plk1 stabilizes nuclear SREBP1 by reducing its degradation.|Figure 2.Plk1 phosphorylates threonine 424, serine 467 and serine 486 in nuclear SREBP1 during mitosis. (A) In vitro kinase assay with recombinant nuclear SREBP1a and Plk1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279383 |
Ser486 |
SRGMLDRsRLALCTL |
Homo sapiens |
|
| pmid |
sentence |
| 27579997 |
As illustrated in , the turnover of nuclear SREBP1a was attenuated in the presence of Plk1, confirming that Plk1 stabilizes nuclear SREBP1 by reducing its degradation.|Figure 2.Plk1 phosphorylates threonine 424, serine 467 and serine 486 in nuclear SREBP1 during mitosis. (A) In vitro kinase assay with recombinant nuclear SREBP1a and Plk1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279381 |
Thr424 |
VKTEVEDtLTPPPSD |
Homo sapiens |
|
| pmid |
sentence |
| 27579997 |
As illustrated in , the turnover of nuclear SREBP1a was attenuated in the presence of Plk1, confirming that Plk1 stabilizes nuclear SREBP1 by reducing its degradation.|Plk1 phosphorylates T424, S467 and S486 in nuclear SREBP1 during mitosis. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CDK8 | up-regulates activity
phosphorylation
|
SREBF1 |
0.465 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279688 |
Thr426 |
TEVEDTLtPPPSDAG |
Homo sapiens |
|
| pmid |
sentence |
| 23562092 |
Biochemical analyses reveal that SREBP-1c can be directly phosphorylated by CDK8 at the conserved Threonine-402 residue (T402) in vitro and in cultured mammalian cells ( xref ).|Therefore, the mechanism of CDK8 regulating SREBP functions is primarily through the phosphorylation initiated control of nuclear SREBP-1 protein stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
PK |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270288 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Well-described targets of srebp-1 and the carbohydrate response element binding protein (chrebp), which include the following: fatty acid synthase (fas), acetyl coa carboxylase (acc1), and liver pyruvate kinase (l-pk) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267799 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Well-described targets of srebp-1 and the carbohydrate response element binding protein (chrebp), which include the following: fatty acid synthase (fas), acetyl coa carboxylase (acc1), and liver pyruvate kinase (l-pk) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | up-regulates quantity by expression 
transcriptional regulation
|
MTTP |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252113 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11111091 |
SREBP1 increased the expression of MTP and increased the assembly and secretion of VLDL containing apo B100. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | up-regulates
|
Lipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228614 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15589694 |
In vivo studies using transgenic and knockout mice suggest that SREBP-1c is involved in FA synthesis and insulin induced glucose metabolism (particularly in lipogenesis), |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Insulin Signaling, MTOR Signaling |
| + |
MBTPS1 | up-regulates activity
cleavage
|
SREBF1 |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267497 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 10644685 |
We present evidence that SKI-1 processes peptides mimicking the cleavage sites of the SKI-1 prosegment, pro-brain-derived neurotrophic factor, and the sterol regulatory element-binding protein SREBP-2 |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
PCSK9 |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255222 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17921436 |
Expression of nuclear forms of sterol-regulatory element binding protein-1 (SREBP-1) and SREBP-2 dramatically increased the promoter activity of PCSK9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF139 | down-regulates quantity
ubiquitination
|
SREBF1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271957 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20068067 |
Induction of TRC8 destabilized the precursor forms of the transcription factors SREBP-1 and SREBP-2. TRC8 destablizes SREBP precursors in a RING and proteasome-dependent manner |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
FASN |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142294 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Well-described targets of srebp-1 and the carbohydrate response element binding protein (chrebp), which include the following: fatty acid synthase (fas), acetyl coa carboxylase (acc1), and liver pyruvate kinase (l-pk) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242884 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20373869 |
Ultimately, both the AKT and MAPK transduction pathways regulate FASN expression through the modulation of expression of sterol regulatory element-binding protein (SREBP)-1c, which binds to regulatory elements in the FASN promoter. Proto-oncogene FBI-1 (Pokemon), a transcription factor of the bric--brac tramtrack broad complex/pox viruses and zinc fingers (BTB/POZ) domain family, interacts directly with SREBP-1c through its DNA-binding domain to synergistically activate the transcription of FASN |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
SIRT6 | up-regulates activity
binding
|
SREBF1 |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268158 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25083875 |
SIRT6 directs chromatin recruitment of CLOCK:BMAL1 and SREBP1.Importantly, SIRT6 also controls SREBP-1 recruitment to target promoters, such as Fasn, and helps maintain proper cyclic transcription. In fact, circadian metabolomics analyses reveal that SIRT6 controls lipid metabolism, contributing to the regulation of pathways involved in fatty acid synthesis and beta oxidation, triglyceride storage, signaling, and cellular membrane lipids. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
PKM |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166381 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Well-described targets of srebp-1 and the carbohydrate response element binding protein (chrebp), which include the following: fatty acid synthase (fas), acetyl coa carboxylase (acc1), and liver pyruvate kinase (l-pk) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142297 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Well-described targets of srebp-1 and the carbohydrate response element binding protein (chrebp), which include the following: fatty acid synthase (fas), acetyl coa carboxylase (acc1), and liver pyruvate kinase (l-pk) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity
transcriptional regulation
|
SREBF1 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251645 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22355693 |
These results show that GSK3β is involved in regulating phosphorylation and activation of C/EBPβ and that this transcription factor is required to transactivate srebf1a expression, leading to the early steps of adipogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
ELOVL6 |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267943 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 18226595 |
These data demonstrated that Elovl-6 is regulated directly and primarily by SREBP-1c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCAP | up-regulates activity
relocalization, binding
|
SREBF1 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267501 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 12202038 |
SCAP contains two domains: an NH2-terminal membrane attachment domain with eight membrane-spanning helices (Nohturfft et al., 1998b) and a long COOH-terminal extension that contains multiple copies of a WD40 repeat sequence, which forms a propeller-like structure that binds to the COOH-terminal domains of the SREBPs, thereby permitting the escort function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256210 |
|
|
Cricetulus griseus |
|
| pmid |
sentence |
| 12242332 |
Insig-2, a second protein of the endoplasmic reticulum that blocks the processing of sterol regulatory element-binding proteins (SREBPs) by binding to SCAP (SREBP cleavage-activating protein) in a sterol-regulated fashion, thus preventing it from escorting SREBPs to the Golgi. By blocking this movement, insig-2, like the previously described insig-1, prevents the proteolytic processing of SREBPs by Golgi enzymes, thereby blocking cholesterol synthesis. |
|
| Publications: |
2 |
Organism: |
Cricetulus Griseus |
| + |
RPS6KB1 | up-regulates
|
SREBF1 |
0.42 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167190 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 20670887 |
We find that srebp1 and 2 promote proliferation downstream of mtorc1, and the activation of these transcription factors is mediated by s6k1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Insulin Signaling, MTOR Signaling |
| + |
RNF20 | down-regulates activity
ubiquitination
|
SREBF1 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278643 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24425205 |
Here, we reveal that RNF20-induced SREBP1c ubiquitination down-regulates hepatic lipogenic activity upon PKA activation.|Overexpression of RNF20 represses SREBP1c activity, leading to a decrease in the expression of lipogenic genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
ACACA |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11994399 |
SREBP-1c–responsive genes include those for ATP citrate lyase (which produces acetyl-CoA) and acetyl-CoA carboxylase and fatty acid synthase (which together produce palmitate [C16:0]). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | down-regulates activity
phosphorylation
|
SREBF1 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176497 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21892142 |
Ampk was recently found to phosphorylate a conserved serine near the cleavage site within srebp1, suppressing its activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
ELOVL |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267944 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 18226595 |
These data demonstrated that Elovl-6 is regulated directly and primarily by SREBP-1c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
ACLY |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267956 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11994399 |
SREBP-1c–responsive genes include those for ATP citrate lyase (which produces acetyl-CoA) and acetyl-CoA carboxylase and fatty acid synthase (which together produce palmitate [C16:0]). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KB1 | up-regulates activity
phosphorylation
|
SREBF1 |
0.42 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280120 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33240877 |
Besides promoting protein synthesis, S6K1 also phosphorylates and activates sterol regulatory element binding protein 1 and 2 (SREBP and SREBP2), which promotes de novo lipid synthesis that is critical for cell growth and proliferation.|Besides promoting protein synthesis, S6K1 also phosphorylates and activates sterol regulatory element-binding protein 1 and 2 (SREBP and SREBP2), which promotes de novo lipid synthesis that is critical for cell growth and proliferation ( xref ). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Insulin Signaling, MTOR Signaling |
| + |
SREBF1 | up-regulates activity
|
PPARG |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170607 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9539737 |
Finally, we demonstrate directly that cells expressing ADD1/SREBP1 produce and secrete lipid molecule(s) that bind directly to PPARgamma, displacing the binding of radioactive thiazolidinedione ligands |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock, MTOR Signaling |
| + |
SREBF1 | down-regulates quantity by repression
transcriptional regulation
|
SND1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259137 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29296233 |
These findings reveal that SREBP-2 and SREBP-1 bind to specific sites in SND1 promoter and regulate SND1 transcription in opposite ways; it is induced by SREBP-2 activating conditions and repressed by SREBP-1 overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | up-regulates
|
VLDL_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252112 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11111091 |
SREBP1 increased the expression of MTP and increased the assembly and secretion of VLDL containing apo B100. SREBP1 induced the expression of the genes regulating the synthesis of all VLDL lipids |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | up-regulates activity
phosphorylation
|
SREBF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270081 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 10915800 |
Map kinases erk1/2 phosphorylate sterol regulatory element-binding protein (srebp)-1a at serine 117 in vitro. mutation of serine 117 to alanine abolished erk2-mediated phosphorylation in vitro and the map kinase-related transcriptional activation of srebp-1a by insulin and platelet-derived growth factor in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MBTPS2 | up-regulates activity
cleavage
|
SREBF1 |
0.668 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267499 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 10419520 |
In order to activate transcription, the NH2-terminal domain of the SREBP must be released from the membrane so that it can enter the nucleus. This release has been studied most extensively for one of the SREBPs, namely, SREBP-2. However, the mechanism appears to be similar for the other SREBPs (SREBP-1a and -1c) (1). Release of the NH2-terminal domain is accomplished by a two-step proteolytic event that is regulated by sterols (3). In sterol-depleted mammalian cells, this proteolysis is initiated by the Site-1 protease (S1P), which cleaves human SREBP-2 between the Leu522-Ser523 bond in the sequence RSVL S (4). This cleavage requires formation of a complex between SREBP and SCAP, a polytopic membrane protein of the ER, and it is prevented when this complex is disrupted |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
SREBF1 | down-regulates quantity by repression 
transcriptional regulation
|
LRP1 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254462 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20980003 |
In the present study we report that specific silencing of either SREBP-1 or SREBP-2 enhanced LRP1 whereas overexpression of the active SREBP isoforms decreased LRP1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF1 | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253132 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12923220 |
IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells|evidence that IDH1 may regulate lipogenesis in hepatic cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SREBF1
- 
- 