Summary

Name PAK1
Full Name Serine/threonine-protein kinase PAK 1
Synonyms Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK
Primary ID Q13153
Links - -
Type protein
Relations 96
Pathways EGFR Signaling, T cell activation
Function Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:30290153). Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIA 0.595
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation H3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KIF2C 0.397
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PGAM1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TBCB 0.463
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NET1 0.253
Publications: 3 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CTBP1 0.419
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GNAZ 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png phosphorylation STMN1 0.388
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PAK1 0.337
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PAK1 0.394
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation PAK1 0.397
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation PAK1 0.394
Publications: 1
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1 0.365
Publications: 3 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1 0.2
Publications: 3 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation PAK1 0.2
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:EGFR Signaling, T cell activation, Toll like receptors
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1 0.342
Publications: 3 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation ELF3 0.472
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FLNA 0.783
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ILK 0.426
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SNAI1 0.416
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PXN 0.647
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ITGB3BP 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K1 0.559
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ARAF 0.27
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.554
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.58
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HACE1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTTN 0.694
Publications: 4 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation FXR1 0.275
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation PLK1 0.526
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NF2 0.627
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation VIM 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1 0.4
Publications: 2 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1 0.309
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation SYN1 0.355
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K1 0.512
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Toll like receptors
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.538
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MORC2 0.379
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.341
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SORT1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DYNLL1 0.386
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png phosphorylation ARHGEF2 0.361
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation ATG5
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation PAK1 0.249
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ARPC1B 0.552
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PAK1 0.411
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation PAK1 0.514
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation PA2G4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AURKA 0.387
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PAK1 0.345
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PAK1 0.364
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:EGFR Signaling, T cell activation
+ up-regulates img/direct-activation.png phosphorylation PGM1 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LIMK1 0.593
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PAK1 0.391
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PAK1 0.695
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:EGFR Signaling, T cell activation
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL6 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PAK1 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PAK1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PAK1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, T cell activation, Toll like receptors
+ up-regulates activity img/direct-activation.png binding PAK1 0.779
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation MEK1/2 0.559
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, T cell activation, Toll like receptors
+ down-regulates img/direct_inhibition.png phosphorylation WEE1 0.303
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PGAM 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PAK1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, T cell activation, Toll like receptors
+ up-regulates img/direct-activation.png binding PAK1 0.771
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PAK1 0.94
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation MYLK 0.532
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PAK1 0.427
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates activity img/direct-activation.png binding PAK1 0.695
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling, T cell activation