| + |
PORCN | up-regulates activity 
palmitoylation
|
WNT3A |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256598 |
Ser209 |
KCKCHGLsGSCEVKTC |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20826466 |
And WNT3A binding to WLS requires PORCN-dependent lipid modification of WNT3A at serine 209. Inhibition of vacuolar acidification results in accumulation of the WNT3A-WLS complex both in cells and at the plasma membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates 
|
ALPL |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183538 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19175684 |
Wnt3a and bmp-9 enhanced each other's ability to induce alp in mscs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates activity
binding
|
LRP5 |
0.704 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169657 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21078818 |
Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt?Beta-catenin signaling.All the frizzled genes studied have |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131826 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
SOST | down-regulates 
|
WNT3A |
0.588 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188964 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19874086 |
It has been shown that both sclerostin and dkk1 act physiologically as downstream mole-cules of bmp signaling to inhibit canonical wnt sig-naling and therefore negatively regulate bone mass |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195684 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
It has been shown that both sclerostin and dkk1 act physiologically as downstream mole-cules of bmp signaling to inhibit canonical wnt sig-naling and therefore negatively regulate bone mass |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates activity
binding
|
FZD1 |
0.798 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73036 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10601008 |
Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt?Beta-catenin signaling.All the frizzled genes studied have a complex and partially overlapping pattern of expression in different regions of the embryo, and many of them (fz1, 3, 7, 8 and 9) have specific expression in the epithelial somites as well as in the newly formed myotomes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169651 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21078818 |
Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt?Beta-catenin signaling.All the frizzled genes studied have a complex and partially overlapping pattern of expression in different regions of the embryo, and many of them (fz1, 3, 7, 8 and 9) have specific expression in the epithelial somites as well as in the newly formed myotomes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates activity
binding
|
FZD3 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169654 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21078818 |
We demonstrate here that prototype canonical Wnt3a and noncanonical Wnt5a ligands specifically trigger completely unrelated endogenous coreceptors-LRP5/6 and Ror1/2, respectively-through a common mechanism that involves their Wnt-dependent coupling to the Frizzled (Fzd) coreceptor and recruitment of shared components, including dishevelled (Dvl), axin, and glycogen synthase kinase 3 (GSK3) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73039 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10601008 |
Here we focus on the role of Wnts, their putative receptors Frizzled and the soluble antagonist Frzb1 in regulating mammalian myogenesis. Although it is becoming evident that the signaling downstream of Frizzled receptors is much more complex than anticipated, it is conceivable that it may lead to transcriptional activation of Myf5 and MyoD and to initiation of myogenesis. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates quantity by stabilization
|
FBN1 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251894 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17943183 |
Wnt3a markedly stimulated matrix assembly of microfibrillar proteins, including Fbn-1, by cultured fibroblasts, suggesting that Wnts contribute to increased microfibrillar matrices in Tsk skin.Wnt3a stimulates Fbn-1 matrix formation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WNT3A | up-regulates activity
binding
|
Frizzled |
0.811 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255650 |
|
|
|
|
| pmid |
sentence |
| 18697834 |
Wnt1, Wnt3a and Wnt5a all induced a statistically greater degree of proliferation than control cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253128 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21078818 |
Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt Beta-catenin signaling. |
|
| Publications: |
2 |
Organism: |
, Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT3A | up-regulates activity
binding
|
LRP6 |
0.793 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131829 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins are a large family of secreted glycoproteins. Wnt proteins bind to the Frizzled receptors and LRP5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169660 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21078818 |
Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt?Beta-catenin signaling.All the frizzled genes studied have |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148671 |
|
|
Homo sapiens |
HeLa-S3 Cell |
| pmid |
sentence |
| 16890161 |
Here, we present evidence that lrp6 is internalized with caveolin and that the components of this endocytic pathway are required not only for wnt-3a-induced internalization of lrp6 but also for accumulation of beta-catenin. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT3A | up-regulates
binding
|
FZD2 |
0.754 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19910923 |
It was also shown that wnt5a inhibits the beta-catenin pathway by competing with wnt3a for binding to fz2, and that the impairment of clathrin-mediated internalization does not affect this wnt5a inhibitory action. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPC4 | up-regulates
binding
|
WNT3A |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195749 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22302992 |
Gpc4 bound to wnt3a and wnt5a which activate the beta-catenin-dependent and -independent pathways, respectively, and colocalized with wnts on the cell surface. Expression of gpc4 enhanced the wnt3a-dependent beta-catenin pathway and the wnt5a-dependent beta-catenin-independent pathway, and knockdown of gpc4 suppressed both pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates
binding
|
RYK |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129580 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15454084 |
Here, we report that ryk directly binds wnt-1 and wnt-3a via its wif domain and is required for the tcf. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DKK1 | down-regulates
|
WNT3A |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195573 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
It has been shown that both sclerostin and dkk1 act physiologically as downstream molecules of bmp signaling to inhibit canonical wnt signaling and therefore negatively regulate bone mass. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188961 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19874086 |
It has been shown that both sclerostin and dkk1 act physiologically as downstream molecules of bmp signaling to inhibit canonical wnt signaling and therefore negatively regulate bone mass. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling |
| + |
SOSTDC1 | down-regulates activity
|
WNT3A |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242714 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 21113658 |
In this context, SOSTDC1 leads to decreased cellular proliferation and inhibition of Wnt3a- and BMP-7-induced signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERG | up-regulates quantity by expression
transcriptional regulation
|
WNT3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261598 |
|
|
Mus musculus |
LNCaP Cell |
| pmid |
sentence |
| 23913826 |
Interestingly, our data showed that ERG drastically induced Wnt ligand gene expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WNT3A | up-regulates activity
|
DVL1 |
0.692 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180803 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18772438 |
Wnt3a stimulates the formation of phosphatidylinositol 4,5-bisphosphates [ptdins (4,5)p2] through frizzled and dishevelled, the latter of which directly interacted with and activated pip5ki. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WLS | up-regulates activity
relocalization
|
WNT3A |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256599 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20826466 |
WNT secretion requires its binding to the carrier protein wntless (WLS); |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates
binding
|
FZD8 |
0.798 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197638 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22653731 |
Structural basis of wnt recognition by frizzled. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
WNT3A
- 
- 