| + |
SETD2 | up-regulates activity 
methylation
|
STAT1 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269091 |
Lys525 |
QLNMLGEkLLGPNAS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 28753426 |
SETD2 enhances antiviral immunity by directly methylating STAT1 on K525. Mechanistically, SETD2 directly mediates STAT1 methylation on lysine 525 via its methyltransferase activity, which reinforces IFN-activated STAT1 phosphorylation and antiviral cellular response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMK2B | up-regulates
phosphorylation
|
STAT1 |
0.385 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154771 |
Ser727 |
TDNLLPMsPEEFDEV |
Homo sapiens |
|
| pmid |
sentence |
| 17502367 |
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMK2G | up-regulates activity
phosphorylation
|
STAT1 |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250706 |
Ser727 |
TDNLLPMsPEEFDEV |
|
NIH-3T3 Cell |
| pmid |
sentence |
| 11972023 |
For maximal gene activation, S727 in the transcription activation domain of Stat1 also is inducibly phosphorylated by IFN-gamma. We previously purified a group of nuclear proteins that interact specifically with the Stat1 transcription activation domain. In this report, we identified one of them as the multifunctional Ca(2+)/calmodulin-dependent kinase (CaMK) II. We demonstrate that IFN-gamma mobilizes a Ca(2+) flux in cells and activates CaMKII. CaMKII can interact directly with Stat1 and phosphorylate Stat1 on S727 in vitro. Inhibition of Ca(2+) flux or CaMKII results in a lack of S727 phosphorylation and Stat1-dependent gene activation, suggesting in vivo phosphorylation of Stat1 S727 by CaMKII. |
|
| Publications: |
1 |
| + |
CDK8 | up-regulates activity
phosphorylation
|
STAT1 |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273179 |
Ser727 |
TDNLLPMsPEEFDEV |
|
|
| pmid |
sentence |
| 29239838 |
We previously demonstrated that Mediator kinase inhibitor cortistatin A (CA) reduced proliferation of JAK2-mutant AML in vitro and in vivo and also suppressed CDK8-dependent phosphorylation of STAT1 at serine 727. Here we report that phosphorylation of STAT1 S727 promotes the proliferation of AML cells with JAK-STAT pathway activation. |
|
| Publications: |
1 |
| + |
CKM complex | up-regulates activity
phosphorylation
|
STAT1 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273182 |
Ser727 |
TDNLLPMsPEEFDEV |
|
|
| pmid |
sentence |
| 29239838 |
We previously demonstrated that Mediator kinase inhibitor cortistatin A (CA) reduced proliferation of JAK2-mutant AML in vitro and in vivo and also suppressed CDK8-dependent phosphorylation of STAT1 at serine 727. Here we report that phosphorylation of STAT1 S727 promotes the proliferation of AML cells with JAK-STAT pathway activation. |
|
| Publications: |
1 |
| + |
PRKCD | up-regulates
phosphorylation
|
STAT1 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154791 |
Ser727 |
TDNLLPMsPEEFDEV |
Homo sapiens |
|
| pmid |
sentence |
| 17502367 |
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
STAT1 |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154779 |
Ser727 |
TDNLLPMsPEEFDEV |
Homo sapiens |
|
| pmid |
sentence |
| 17502367 |
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
PTPN11 | down-regulates activity 
dephosphorylation
|
STAT1 |
0.736 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248673 |
Ser727 |
TDNLLPMsPEEFDEV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12270932 |
SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei|In SHP-2-/- mouse fibroblast cells, Stat1 phosphorylation at both the tyrosine residue Tyr(701) and the serine residue Ser(727) |Overexpression of SHP-2 in 293T cells inhibited IFNgamma-dependent Stat1 phosphorylation and suppressed Stat1-dependent induction of luciferase activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248672 |
Tyr701 |
DGPKGTGyIKTELIS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12270932 |
SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei|In SHP-2-/- mouse fibroblast cells, Stat1 phosphorylation at both the tyrosine residue Tyr(701) and the serine residue Ser(727) |Overexpression of SHP-2 in 293T cells inhibited IFNgamma-dependent Stat1 phosphorylation and suppressed Stat1-dependent induction of luciferase activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling |
| + |
IKBKE | up-regulates
phosphorylation
|
STAT1 |
0.409 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154775 |
Ser727 |
TDNLLPMsPEEFDEV |
Homo sapiens |
|
| pmid |
sentence |
| 17502367 |
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNK2 | up-regulates activity
phosphorylation
|
STAT1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278348 |
Tyr701 |
DGPKGTGyIKTELIS |
Homo sapiens |
|
| pmid |
sentence |
| 28739485 |
Hence, ACK1 activates STAT1 through its kinase activity.|We found that wild-type ACK1 and to a larger extent constitutively active ACK1 increased the phosphorylation of cytoplasmic STAT1 at Y701. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8 | up-regulates activity
phosphorylation
|
STAT1 |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251101 |
Tyr701 |
DGPKGTGyIKTELIS |
Mus musculus |
Embryonic Stem Cell |
| pmid |
sentence |
| 24913968 |
SP600125 prevented phosphorylation of STAT1 at Tyr701 site [..] Western blot analysis confirmed that blocking p-JNK using SP600125 markedly reduced STAT3 localization in the nucleus and STAT1 phosphorylation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EGFR Signaling |
| + |
FGFR3 | up-regulates activity
phosphorylation
|
STAT1 |
0.66 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251138 |
Tyr701 |
DGPKGTGyIKTELIS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10918587 |
Activation of Stat1 and Stat3 by FGFR derivatives. Lysates of 293T cells transfected as indicated were analysed by Western blotting using Phospho-Stat1 (Y701) antisera (top) or Stat1 antisera (bottom). (b) The same lysates in (a) were re-examined for phosphorylated Stat3 by Western blotting with Phospho-Stat3 (Y705) (top). all three FGFR family members examined here are able to lead to Stat activation. Expression of the 'TDII-like' derivatives of FGFR1, FGFR3, and FGFR4, as well as myrR1-WT, led to phosphorylation of both Stat1 and Stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates activity
phosphorylation
|
STAT1 |
0.785 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236373 |
Tyr701 |
DGPKGTGyIKTELIS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11823427 |
The central event in cytokine_dependent transcriptional regulation is phosphorylation of STATs on a single tyrosine residue at their C_terminus (Darnell, 1997b). The reaction is catalyzed by cytokine receptor_associated tyrosine kinases of the Janus type (Jak) at the cell membrane and triggers the homo_ and heterodimerization of STAT molecules via reciprocal phosphotyrosineSH2 domain interactions |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-30905 |
Tyr701 |
DGPKGTGyIKTELIS |
in vitro |
|
| pmid |
sentence |
| 7657660 |
Stat1 was phosphorylated at tyr 701 in jak immune complex kinase reaction. The stat1 and stat2 proteins are present in the cytoplasm of untreated cells;upon stimulation with ifn-g, They become rapidly activated by tyrosine phosphorylation at a single site catalyzed by receptor associated jak (janus) kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236239 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9020188 |
The stat1 and stat2 proteins are present in the cytoplasm of untreated cells;upon stimulation with ifn-g they become rapidly activated by tyrosine phosphorylation at a single site catalyzed by receptor associated jak (janus) kinases. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, In Vitro |
| Pathways: | EBV infection, SARS-CoV CYTOKINE STORM |
| + |
TYK2 | up-regulates activity
phosphorylation
|
STAT1 |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-246943 |
Tyr701 |
DGPKGTGyIKTELIS |
in vitro |
|
| pmid |
sentence |
| 7657660 |
Co-expression of Stat1 with Tyk2, Jak1, or Jak2 resulted in the specific tyrosine phosphorylation of Stat1 at Tyr701Phosphorylation of purified Stat1 was necessary and sufficient for the acquisition of DNA binding activity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | EBV infection |
| + |
JAK2 | up-regulates
phosphorylation
|
STAT1 |
0.802 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235709 |
Tyr701 |
DGPKGTGyIKTELIS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15322115 |
Phosphorylation at tyr701 by the janus family of tyrosine kinases (jak) leads to stat1 dimerization via its src homology 2 domains, exposure of a dimer-specific nuclear localization signal, and subsequent nuclear translocation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256248 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21576360 |
When IFN-γ binds to its receptor, the receptor-associated protein tyrosine kinases Janus kinase I (JAK1) and JAK2 are activated (37). This leads to the phosphorylation of STAT1, which then dimerizes, translocates to the nucleus, and activates its target promoters, including the pIV promoter of Ciita |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255071 |
|
|
|
|
| pmid |
sentence |
| 7888666 |
We found that IL-5 induced two GAS-binding proteins in the nuclear extract from eosinophils. One of them was identified as STAT1 (p91). |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, |
| Tissue: |
Skeletal Muscle |
| Pathways: | EGFR Signaling, EBV infection |
| + |
SRC | up-regulates activity
phosphorylation
|
STAT1 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235696 |
Tyr701 |
DGPKGTGyIKTELIS |
Homo sapiens |
|
| pmid |
sentence |
| 14978237 |
The tyr701 phosphorylation of signal transducer and activator of transcription 1 (stat1) induced by interferon-gamma (ifn-gamma) and 12-o-tetradecanoylphorbol 13-acetate (tpa) was inhibited by the protein kinase c (pkc) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the src kinase inhibitor pp2. An association between c-src and stat1 was increased by ifn-gamma and tpa, indicating the direct phosphorylation of stat1 by pkc-dependent c-src activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Lung |
| Pathways: | EGFR Signaling |
| + |
KIT | up-regulates activity
phosphorylation
|
STAT1 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251365 |
Tyr701 |
DGPKGTGyIKTELIS |
in vitro |
|
| pmid |
sentence |
| 21135090 |
KIT is responsible for the permanent phosphorylation of all three STAT proteins. STAT1, -3, and -5 were phosphorylated on their activation-specific Tyr701, Tyr704, and Tyr694, respectively, following KIT stimulation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FGFR4 | up-regulates activity
phosphorylation
|
STAT1 |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251141 |
Tyr701 |
DGPKGTGyIKTELIS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10918587 |
Activation of Stat1 and Stat3 by FGFR derivatives. Lysates of 293T cells transfected as indicated were analysed by Western blotting using Phospho-Stat1 (Y701) antisera (top) or Stat1 antisera (bottom). (b) The same lysates in (a) were re-examined for phosphorylated Stat3 by Western blotting with Phospho-Stat3 (Y705) (top). all three FGFR family members examined here are able to lead to Stat activation. Expression of the 'TDII-like' derivatives of FGFR1, FGFR3, and FGFR4, as well as myrR1-WT, led to phosphorylation of both Stat1 and Stat3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN2 | down-regulates
dephosphorylation
|
STAT1 |
0.726 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90814 |
Tyr701 |
DGPKGTGyIKTELIS |
Homo sapiens |
|
| pmid |
sentence |
| 12138178 |
Stat1 becomes tyrosine phosphorylated and translocates into the nucleus, where it binds to dna to activate transcription. The activity of stat1 is dependent on tyrosine phosphorylation, and its inactivation in the nucleus is accomplished by a previously unknown protein tyrosine phosphatase (ptp). We have now purified a stat1 ptp activity from hela cell nuclear extract and identified it as tc45, the nuclear isoform of the t-cell ptp (tc-ptp). Tc45 can dephosphorylate stat1 both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRG | up-regulates activity
dephosphorylation
|
STAT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254727 |
Tyr701 |
DGPKGTGyIKTELIS |
in vitro |
|
| pmid |
sentence |
| 25624455 |
PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and VCL correlates with tyrosine dephosphorylation. In contrast, SRC inhibition correlates with hyperphosphorylation of the inhibitory Tyr530 residue and with dephosphorylation of the activatory Tyr419. Moreover, CDK2 and CTTN inhibition correlates with a hyperphosphorylation of the inhibitory Tyr15 and Tyr470, respectively. In contrast, a subgroup of 13 proteins, including BLNK, DOK2, ERBB2, GRIN2B, INSR, PDGFRA, PRKCD, PXN, STAT1, STAT2, STAT3, STAT5A, and ZAP70, appears to be activated by PTPRG activity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PTPN2 | down-regulates activity
dephosphorylation
|
STAT1 |
0.726 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248402 |
Tyr701 |
DGPKGTGyIKTELIS |
Homo sapiens |
|
| pmid |
sentence |
| 12138178 |
Upon interferon (IFN) stimulation, Stat1 becomes tyrosine phosphorylated and translocates into the nucleus, where it binds to DNA to activate transcription. The activity of Stat1 is dependent on tyrosine phosphorylation, and its inactivation in the nucleus is accomplished by a previously unknown protein tyrosine phosphatase (PTP). We have now purified a Stat1 PTP activity from HeLa cell nuclear extract and identified it as TC45, the nuclear isoform of the T-cell PTP (TC-PTP). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133279 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15780598 |
Upon ligand binding, IL-2R , IL-6R or LeptinR , IFN-_R , IFN-_R and PRLR or growth hormone (GH) receptor associated JAKs become activated. These JAKs mediate phosphorylation of specific tyrosine residues and recruit STATs. Activated STATs are released from the receptor and translocate to the nucleus. PTP1B dephosphorylates JAK2, TYK2 and STAT5 . The 45-kDa form of TC-PTP was shown to dephosphorylate JAK1 and JAK3 as well as STAT1, STAT3 and STAT5. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
STAT1 | down-regulates quantity by repression 
transcriptional regulation
|
MMP13 |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255235 |
|
|
Homo sapiens |
Chondrocyte |
| pmid |
sentence |
| 17179173 |
IFNgamma, through its receptor, activates STAT1, which binds with CBP/p300 coactivator, sequesters it from the cell system, and thus inhibits transcriptional induction of the MMP13 gene in chondrocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates 
|
TBX21 |
0.504 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254293 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16386358 |
T-bet is a transcription factor detected in Th1, but not in Th0 or Th2 cells. Its expression is up-regulated by IFN-gamma, through a STAT-1-dependent mechanism |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | down-regulates activity
binding
|
STAT1 |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249552 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 10982806 |
STAT6 mediates suppression of STAT1 and NF-kB-dependent transcription by distinct mechanisms. Both processes are dependent upon the STAT6 transactivation domain and may involve sequestration of necessary but different transcriptional coactivator proteins. These two suppressive mechanisms are controlled differentially by the nature of the STAT6 DNA-binding site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGFR | up-regulates
phosphorylation
|
STAT1 |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121962 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
The transcription factors stat1, stat3, and stat5 are directly phosphorylated by erbb-1, subsequent to which they dimerize through phosphotyrosine-sh2 domain interactions and translocate to the nucleus to activate gene trascription critical for proliferation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235689 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22693070 |
The transcription factors stat1, stat3, and stat5 are directly phosphorylated by erbb-1, subsequent to which they dimerize through phosphotyrosine-sh2 domain interactions and translocate to the nucleus to activate gene trascription critical for proliferation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
SOCS1 |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226484 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19482358 |
Socs1 expression is induced in the human keratinocytes HaCaT cell line through sequential activation of STAT1 and IRF-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
IL12A |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249499 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19029990 |
STAT1 binds as a homodimer to cis elements known as gammaactivated sequences in the promoters of the genes encoding NOS2, the MHC class II transactivator (CIITA) and IL-12, among others. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SARS-CoV CYTOKINE STORM |
| + |
CNTFR | up-regulates
|
STAT1 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72771 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10582086 |
Signal transduction by cntf requires that it bind first to cntfr alpha, permitting the recruitment of gp130 and lifr beta, forming a tripartite receptor complex. Cntf-induced heterodimerization of the beta receptor subunits leads to tyrosine phosphorylation (through constitutively associated jaks), and the activated receptor provides docking sites for sh2-containing signaling molecules, such as stat proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
S100A10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255237 |
|
|
Homo sapiens |
HeLa Cell, BEAS-2B Cell |
| pmid |
sentence |
| 12645529 |
IFN-gamma induced a rapid tyrosine phosphorylation and nuclear translocation of STAT1 protein, which is involved in the binding to the GAS-2 site in the p11 promoter by EMSA analysis. These data suggest that IFN-gamma-induced p11 expression is mediated through the binding of STAT1 to GAS sites in the p11 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
NOS2 |
0.439 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249497 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19029990 |
STAT1 binds as a homodimer to cis elements known as gammaactivated sequences in the promoters of the genes encoding NOS2, the MHC class II transactivator (CIITA) and IL-12, among others. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNGR2/INFGR1 | up-regulates activity
binding
|
STAT1 |
0.669 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249494 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23898330 |
In the classical model of IFNgamma signaling, dimeric IFNgamma cross-links the IFNGR1 receptor subunit that results in allosteric changes in receptor cytoplasmic domain. This results in movement of JAK2 from receptor subunit IFNGR2 to IFNGR1. The JAKs autophosphorylate and then phosphorylate IFNGR1 cytoplasmic domain. This results in binding, phosphorylation, and dimer formation of STAT1_. The dimeric STAT1_ dissociates from receptor and undergoes nuclear translocation via an intrinsic NLS for specific gene activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SARS-CoV CYTOKINE STORM |
| + |
STAT1 | up-regulates
|
M1_polarization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249496 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19029990 |
STAT1 binds as a homodimer to cis elements known as gammaactivated sequences in the promoters of the genes encoding NOS2, the MHC class II transactivator (CIITA) and IL-12, among others. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
CIITA |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249498 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19029990 |
STAT1 binds as a homodimer to cis elements known as gammaactivated sequences in the promoters of the genes encoding NOS2, the MHC class II transactivator (CIITA) and IL-12, among others. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Host translation inhibitor nsp1 | down-regulates activity
|
STAT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262502 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17715225 |
We mapped a strong inhibitory activity to SARS-CoV nonstructural protein 1 (nsp1) and show that expression of nsp1 significantly inhibited the activation of all three virus-dependent signaling pathways. We show that expression of nsp1 significantly inhibited IFN-dependent signaling by decreasing the phosphorylation levels of STAT1 while having little effect on those of STAT2, JAK1, and TYK2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SARS-CoV CYTOKINE STORM |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
IRF7 |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255231 |
|
|
Homo sapiens |
Keratinocyte |
| pmid |
sentence |
| 16628196 |
The activation of STAT1 by IFNs not only induces chemokine production, but also results in the expression of IRF-7 and TLR3, thus amplifying the dsRNA-provoked reaction in a positive-feedback manner during viral infection. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SARS-CoV CYTOKINE STORM |
| + |
JAK1 | up-regulates
phosphorylation
|
STAT1 |
0.785 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256247 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21576360 |
When IFN-γ binds to its receptor, the receptor-associated protein tyrosine kinases Janus kinase I (JAK1) and JAK2 are activated (37). This leads to the phosphorylation of STAT1, which then dimerizes, translocates to the nucleus, and activates its target promoters, including the pIV promoter of Ciita |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SARS-CoV CYTOKINE STORM |
| + |
EBNA1 | up-regulates quantity by expression
transcriptional regulation
|
STAT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267614 |
|
|
Homo sapiens |
AGS Cell, HONE-1 Cell |
| pmid |
sentence |
| 17486072 |
EBNA1 enhances the expression and activity of STAT1. EBNA1 also induced STAT1 expression, with associated enhancement of IFNγ-induced activation. The ability of EBNA1 to enhance IFNγ-induced STAT1 signaling was observed at the protein level by enhanced nuclear translocation of STAT1 (Figure 3b) and at the transcriptional level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
TAP1 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254531 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15778351 |
We also show that this cytokine-dependent expression of TAP1 transcripts depends on STAT1 and IFN regulatory factor-2 (IRF-2), but not on IRF-1, and provide evidence that IRF-2 constitutively binds to the TAP1 gene promoter and enhances TAP1 promoter activity. We show that IRF-2 forms a complex with STAT1 and the cytokine-responsive region of the TAP1 promoter in any TPO or IFN-gamma target cells tested. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
6 | down-regulates activity
relocalization
|
STAT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260341 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17108024 |
ORF 6 protein inhibits the translocation of STAT1.SARS-CoV ORF 6 protein, but not ORF 3b or N protein, was able to inhibit the translocation of STAT1-GFP to the nucleus. A higher magnification of the image of ORF 6 protein in cells transfected with STAT1-GFP and treated with IFN-β shows that ORF 6 protein does not colocalize with STAT1, indicating that ORF 6 does not directly interact with STAT1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SARS-CoV CYTOKINE STORM |
| + |
PIAS1 | down-regulates
binding
|
STAT1 |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202039 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23663276 |
Socs1 and socs3 target jak1 and gp130, respectively, near the plasma membrane to prevent cytoplasmic stats from being activated, whereas pias1 principally targets activated stat1 in the cell nucleus and prevents it from binding to dna. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-120548 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14699505 |
Pias1 inhibits binding of stat1 dimers to the response elements in the promoters of target genes |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
ORF6 | down-regulates activity
|
STAT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260271 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 17596301 |
Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CREB5 | down-regulates quantity by repression
transcriptional regulation
|
STAT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253810 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21132541 |
Our result verified CREB5 biological regulation module in the upstream of frontal cortex of HIVE-control patients (MAPKAPK3 activation; DGKG, LY96, TNFRSF11B inhibition) and downstream (ATP6V0E1, CFB, DGKG, MX1, TGFBR3 activation; LGALS3BP, RASGRP3, RDX, STAT1 inhibition), |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Esophageal Cancer Cell Line |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
SOCS3 |
0.669 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249565 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19643666 |
Expression of SOCS1 and SOCS3 is regulated primarily by activation of STAT1 and STAT3, respectively, although their expression can be mediated through other signaling cascades, including the mitogen activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) pathways. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates quantity
transcriptional regulation
|
CIITA |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255752 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9551976 |
A role for STAT1 in regulation of the CIITA promoter is shown by the rescue of IFN-gamma induction by expression of STAT1 in STAT1-defective U3A cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
STAT1 | form complex 
binding
|
STAT1/STAT3 |
0.599 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235661 |
|
|
Mus musculus |
Keratinocyte |
| pmid |
sentence |
| 15284024 |
Stimulation of EGFR induces Tyr701 phosphorylation of STAT1 and initiates complex formation of STAT1 and STAT3 with JAK1 and JAK2. Thereafter, the STATs translocate to the nucleus within 15 min. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
STAT1 | up-regulates activity
binding
|
IRF2 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254532 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15778351 |
We show that IRF-2 forms a complex with STAT1 and the cytokine-responsive region of the TAP1 promoter in any TPO or IFN-gamma target cells tested. Interaction of IRF-2 and STAT1 on the promoter depends on the DNA-binding domain of IRF-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
MUC4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254099 |
|
|
Homo sapiens |
BxPC-3 Cell |
| pmid |
sentence |
| 19757157 |
Through promoter screening, overexpressing methods and luciferase reporter studies, we found that transcription factors CREB, Ets-1, Elk-1 and STAT1 can positively regulate MUC4 expression at the promoter and mRNA level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | down-regulates
binding
|
NfKb-p65/p50 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217418 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16481475 |
Acetylated stat1 is able to interact with nf-kappab p65. As a consequence, p65 dna binding, nuclear localization, and expression of anti-apoptotic nf-kappab target genes decrease. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SARS-CoV CYTOKINE STORM |
| + |
FANCC | up-regulates
|
STAT1 |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-110043 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11520787 |
Fancc is also required for optimal activation of stat1 in response to cytokine and growth factors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT2 | up-regulates activity
binding
|
STAT1 |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17923090 |
We then examined STAT2 acetylation within the b-barrel DBD. A direct interaction between the STAT2-DBD (315485) and STAT1 was detected (Figure 6E) (Li et al., 1997). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
STAT1 |
0.599 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263650 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 22693070 |
In summary, we report in this study that STAT1 expression is upregulated by nuclear EGFR, EGFRvIII and HER2, and that STAT3 synergizes with the three receptors to further enhance STAT1 expression. These novel findings establish a novel link between the mitogenic ErbB signaling pathway and the inflammatory pathway mediated by STAT1. The oncogenic transcription factor STAT3 binds to the STAT1 promoter and synergizes with nuclear EGFR to significantly enhance STAT1 gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, EBV infection, SARS-CoV CYTOKINE STORM |
| + |
STAT1 | up-regulates activity
binding
|
STAT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249495 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19041276 |
Each STAT1 monomer becomes tyrosine phosphorylated at tyrosine 701 by the JAKs, dissociates from the receptor to form a STAT1-STAT1 homodimer which translocates to the nucleus |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, EBV infection, P38 Signaling, SARS-CoV CYTOKINE STORM |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
KRT17 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255233 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21796151 |
IL-17A upregulates keratin 17 expression in keratinocytes through STAT1- and STAT3-dependent mechanisms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | down-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263651 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21433395 |
The signal transducer and activator of transcription (STAT) family of transcription factors transduce signals from a variety of extracellular stimuli, and are important mediators of inflammation, cell survival, differentiation, and proliferation. STATs are activated in response to growth factors, cytokines, and G-CSF binding to cell surface receptor tyrosine kinases. Although structurally similar, the seven STAT family members possess diverse biological roles. For example, STAT1 activation is pro-inflammatory and anti-proliferative, while STAT3 activation is anti-inflammatory and pro-apoptotic. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, EBV infection, P38 Signaling |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
TLR3 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255230 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16628196 |
The activation of STAT1 by IFNs not only induces chemokine production, but also results in the expression of IRF-7 and TLR3, thus amplifying the dsRNA-provoked reaction in a positive-feedback manner during viral infection. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates quantity by expression
transcriptional regulation
|
IL12B |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249500 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19029990 |
STAT1 binds as a homodimer to cis elements known as gammaactivated sequences in the promoters of the genes encoding NOS2, the MHC class II transactivator (CIITA) and IL-12, among others. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | form complex
binding
|
ISGF3 complex |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240606 |
|
|
in vitro |
|
| pmid |
sentence |
| 8943351 |
The first STAT-containing transcription factor to be studied, the alpha-interferon-induced ISGF3, is composed of a Stat1:2 heterodimer and a weak DNA-binding protein, p48. The p48 and Stat1:2 heterodimer do not associate stably in the absence of DNA, but we show that amino acids approximately 150 to 250 of Stat1 and a COOH-terminal portion of p48 exhibit physical interaction, implying contact that stabilizes ISGF3 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | SARS-CoV CYTOKINE STORM |
| + |
SOCS1 | down-regulates quantity by repression
transcriptional regulation
|
STAT1 |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255229 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16628196 |
SOCS1, which is another inducible gene, not only blocks STAT1 activation but also inhibits STAT1-dependent TLR3, IRF-7, and MIP-1α. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | up-regulates
transcriptional regulation
|
CIITA |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256249 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21576360 |
When IFN-γ binds to its receptor, the receptor-associated protein tyrosine kinases Janus kinase I (JAK1) and JAK2 are activated (37). This leads to the phosphorylation of STAT1, which then dimerizes, translocates to the nucleus, and activates its target promoters, including the pIV promoter of Ciita |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
PIAS4 | down-regulates
binding
|
STAT1 |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105723 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11248056 |
First, piasy interacts with stat1 both in vitro and in vivo. The in vivo piasy__stat1 interaction is dependent on cytokine stimulation. Second, piasy can inhibit stat1-mediated gene activation without blocking the dna binding activity of stat1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT1 | down-regulates
binding
|
RELA |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144561 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16481475 |
Acetylated stat1 is able to interact with nf-kappab p65. As a consequence, p65 dna binding, nuclear localization, and expression of anti-apoptotic nf-kappab target genes decrease. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
STAT1
- 
- 