EGFR

Pathway ID: SIGNOR-EGFView in NDEx

Description: The epidermal growth factor receptor (EGFR) signaling pathway regulates growth, survival, proliferation, and differentiation. The binding of extracellular ligands (EGF) induces homo and heterodimerization, transphosphorylation and activation of four ErbB family receptors: EGFR (ErbB1), ErbB2, ErbB3, and ErbB4. These events trigger a cascade of activation of downstream pathways that include, principally, the MAPK, Akt and JNK pathways, culminating in DNA synthesis and cell proliferation.

Curated by: Theodora Pavlidou

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

34 Seed Entities

Organism:
Name Primary ID
SHC1 P29353
MAP3K1 Q13233
HRAS P01112
MYC P01106
BRAF P15056
ARAF P10398
NCK1 P16333
CBLB Q13191
PTPN11 Q06124
SOS1 Q07889
SRC P12931
EGF P01133
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate CHEBI:16618
Cell Growth SIGNOR-PH33
JUN P05412
STAT1 P42224
PAK1 Q13153
FOS P01100
Proliferation SIGNOR-PH4
ELK1 P19419
MAX P61244
GRB2 P62993
MEK1/2 SIGNOR-PF25
JAK1/STAT1/STAT3 SIGNOR-C120
PIK3CA P42336
ERRFI1 Q9UJM3
GAB1 Q13480
MAP2K4 P45985
MAPK8 P45983
ERK1/2 SIGNOR-PF1
EGFR P00533
STAT3 P40763
PDPK1 O15530
AKT SIGNOR-PF24