Summary

Name ABL1
Full Name Tyrosine-protein kinase ABL1
Synonyms Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150 | ABL, JTK7
Primary ID P00519
Links - -
Type protein
Relations 180
Pathways Cell cycle: G2/M phase transition, Myogenesis modulation: DNA damage, P38 Signaling and Myogenesis, Satellite: DDR inhibition
Inhibitors imatinib; nilotinib; dasatinib (anhydrous); bosutinib; ponatinib; imatinib methanesulfonate; [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone; 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide; PD173955; nocodazole; AT9283; regorafenib; DCC-2036
Function Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation, binding ABL1 0.734
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.425
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.262
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.286
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.349
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.276
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JAK2 0.422
Publications: 1 Organism: In Vitro
+ up-regulates quantity img/direct-activation.png phosphorylation PPARG 0.348
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation GMFG 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RAD52 0.671
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation NCK1 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation PSMA7 0.408
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation LGALS3 0.367
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ROBO1 0.583
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.431
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RAPH1 0.29
Publications: 4 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation MUC1 0.471
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA3 0.355
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PRKN 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP63 0.523
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDK5 0.563
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation WASF3 0.564
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CASP9 0.532
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CASP9 0.532
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PSMA7 0.408
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation STX17 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation SPTLC1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JUN 0.546
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation JUN 0.546
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LASP1 0.354
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation WASL 0.57
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation WASL 0.57
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ABI1 0.875
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.464
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CRK 0.749
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation HDAC2 0.29
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation BTK 0.343
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation BTK 0.343
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AHSA1 0.255
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ABL1 0.512
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MYLK 0.306
Publications: 4 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates img/direct-activation.png phosphorylation CAT 0.414
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CAT 0.414
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP4K1 0.387
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ABL2 0.49
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SRCIN1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation DGCR8 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TOP1 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MDM2 0.704
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation RAD9A 0.494
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RAD9A 0.494
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATR 0.578
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png phosphorylation MYOD1 0.292
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation RAD51 0.762
Publications: 4 Organism: Chlorocebus Aethiops, Homo Sapiens, Mus Musculus
Pathways:Cell cycle: G2/M phase transition
+ img/unknown.png phosphorylation PSTPIP1 0.622
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PSTPIP1 0.622
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation HIPK2 0.413
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates activity img/direct-activation.png phosphorylation ABL1 0.2
Publications: 3 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition, P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png dephosphorylation ABL1 0.451
Publications: 2 Organism: Chlorocebus Aethiops, Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation MDM2 0.704
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation YAP1 0.706
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation ABL1 0.349
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PLK1 0.297
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PRKD1 0.345
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STK4 0.349
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation PRKD1 0.345
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKD1 0.345
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAPGEF1 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CD19 0.554
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation RACK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN6 0.424
Publications: 5 Organism: Homo Sapiens, In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation RAD51 0.762
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation APBB1 0.427
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN6 0.424
Publications: 2 Organism: Homo Sapiens, In Vitro
+ up-regulates img/direct-activation.png phosphorylation DDX5 0.369
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation UBE3A 0.277
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PDGFRB 0.504
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PLSCR1 0.394
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.412
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RB1 0.547
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation STK3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CDKN1B 0.574
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.574
Publications: 1 Organism: In Vitro
Pathways:Cell cycle: G2/M phase transition
+ up-regulates activity img/direct-activation.png phosphorylation ERCC6 0.275
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PDGFRB 0.504
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RBM39 0.332
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GPX1 0.475
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP73 0.746
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STK3/4 0.349
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation WRN 0.427
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MTOR 0.467
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CRKL 0.702
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ABL1 0.51
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RIN1 0.747
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ABL1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ABL1 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ABL1 0.277
Publications: 1
+ down-regulates img/direct_inhibition.png binding ABL1 0.547
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding ABL1 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ABL1 0.875
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation YTHDC1 0.309
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/indirect_inhibition.png ABL1 0.622
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png binding ABL1 0.495
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding ABL1 0.338
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ABL1 0.489
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding GRAP 0.27
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DDB2 0.473
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png binding ABL1 0.501
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ABL1 0.608
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EPHB2 0.492
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VAV1 0.411
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ABL1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation ABL1 0.591
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ABL1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAD51 0.762
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition