Summary

Name BCL2
Full Name Apoptosis regulator Bcl-2
Synonyms BCL2_HUMAN
Primary ID P10415
Links - -
Type protein
Relations 83
Pathways Alzheimer, Acute Myeloid Leukemia, BCR-ABL in AML, DNMT3A in AML, FLT3 in AML, KIT in AML, miRNA in AML, MLL fusion protein in AML, AML_TRIPLETS, Autophagy, COVID-19 Causal Network, Colorectal Carcinoma, Death Receptor Signaling, FLT3-ITD signaling, GLP-1 and GIP receptor signaling in PDAC, GPCR_CRC, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Malignant Melanoma, Triple mutant AML, NPM1_new, Non-small-cell lung cancer (NSCLC), p53 in cancer, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION
Inhibitors venetoclax; N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide; gossypol; Obatoclax mesylate; ABT-737; 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexenyl]methyl]-1-piperazinyl]-N-[4-[[(2R)-4-(4-morpholinyl)-1-(phenylthio)butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide; Obatoclax
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png dephosphorylation BCL2 0.321
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation BCL2 0.55
Publications: 5 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.58
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation BCL2 0.2
Publications: 4 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, COVID-19 Causal Network, Colorectal Carcinoma, FLT3-ITD signaling, Inhibition of Apoptosis, Malignant Melanoma, Triple mutant AML, NPM1_new, Non-small-cell lung cancer (NSCLC), SARS-CoV MAPK PERTURBATION
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.558
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCL2 0.2
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, FLT3-ITD signaling, SARS-CoV MAPK PERTURBATION
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION
+ up-regulates activity img/direct-activation.png dephosphorylation BCL2 0.383
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2 0.58
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network
+ up-regulates activity img/direct-activation.png dephosphorylation BCL2 0.469
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2 0.335
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation BCL2 0.558
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCL2 0.346
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates img/direct_inhibition.png phosphorylation BCL2 0.58
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network
+ down-regulates activity img/direct_inhibition.png chemical inhibition BCL2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BECN1 0.738
Publications: 3 Organism: Homo Sapiens
Pathways:Autophagy
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2 0.346
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates quantity img/indirect_inhibition.png BCL2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer, Acute Myeloid Leukemia, BCR-ABL in AML, DNMT3A in AML, FLT3 in AML, KIT in AML, miRNA in AML, MLL fusion protein in AML, AML_TRIPLETS, COVID-19 Causal Network, Colorectal Carcinoma, Death Receptor Signaling, FLT3-ITD signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Malignant Melanoma, Triple mutant AML, NPM1_new, p53 in cancer, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION
+ down-regulates activity img/direct_inhibition.png chemical inhibition BCL2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/indirect_inhibition.png DIABLO 0.49
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BCL2 0.473
Publications: 1
Pathways:Malignant Melanoma
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BCL2 0.416
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BAK1 0.676
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML, Malignant Melanoma, Non-small-cell lung cancer (NSCLC)
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.662
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Mitochondrial Control of Apoptosis
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.819
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png CYCS 0.644
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.263
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png binding BCL2 0.505
Publications: 1 Organism: Homo Sapiens
Tissue: Spinal Cord
Pathways:Autophagy
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BCL2 0.401
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.2
Publications: 1
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Colorectal Carcinoma
+ down-regulates img/indirect_inhibition.png Cell_death 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.748
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, KIT in AML, miRNA in AML, AML_TRIPLETS, Colorectal Carcinoma, FLT3-ITD signaling, Mitochondrial Control of Apoptosis, Malignant Melanoma, Triple mutant AML, NPM1_new, Non-small-cell lung cancer (NSCLC), p53 in cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.458
Publications: 2 Organism: Homo Sapiens, Rattus Norvegicus
Pathways:COVID-19 Causal Network, FLT3-ITD signaling, Inhibition of Apoptosis, Malignant Melanoma, SARS-CoV MAPK PERTURBATION
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BAX 0.634
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer, Acute Myeloid Leukemia, MLL fusion protein in AML, COVID-19 Causal Network, Death Receptor Signaling, FLT3-ITD signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Malignant Melanoma, p53 in cancer, SARS-COV APOPTOSIS
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2 0.748
Publications: 1
Pathways:Acute Myeloid Leukemia, DNMT3A in AML, KIT in AML, miRNA in AML, AML_TRIPLETS, Colorectal Carcinoma, FLT3-ITD signaling, Mitochondrial Control of Apoptosis, Malignant Melanoma, Triple mutant AML, NPM1_new, Non-small-cell lung cancer (NSCLC), p53 in cancer
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png BCL2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BCL2 0.474
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png BCL2 0.2
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization BCL2 0.801
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, FLT3-ITD signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Malignant Melanoma, SARS-COV APOPTOSIS
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.25
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BCL2 0.819
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.634
Publications: 1
Pathways:Alzheimer, Acute Myeloid Leukemia, MLL fusion protein in AML, COVID-19 Causal Network, Death Receptor Signaling, FLT3-ITD signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Malignant Melanoma, p53 in cancer, SARS-COV APOPTOSIS
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png HTRA2 0.251
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2 0.2
Publications: 1 Organism: Homo Sapiens