Summary

Name SMAD2
Full Name Mothers against decapentaplegic homolog 2
Synonyms MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2 | MADH2, MADR2
Primary ID Q15796
Links - -
Type protein
Relations 98
Pathways Myostatin, Macrophage: TGF beta, FAP: BMP, TGFbeta Signaling, Satellite: atrophy, T-Lymphocyte: IL6, T-Lymphocyte: TGF beta
Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png acetylation SMAD2
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates activity img/direct-activation.png acetylation SMAD2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation SMAD2 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD2
Publications: 6 Organism: Homo Sapiens
Tissue: Lung, Breast, Lung
Pathways:T-Lymphocyte: IL6
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.13
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD2 0.30
Publications: 15 Organism: Homo Sapiens
Tissue: Lung, Lung, Breast
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD2 0.16
Publications: 4 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2 0.90
Publications: 3 Organism: Homo Sapiens
Pathways:FAP: BMP, Macrophage: TGF beta, TGFbeta Signaling, T-Lymphocyte: TGF beta
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2
Publications: 3 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates activity img/direct-activation.png binding SMAD2 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization SMAD2 0.56
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage: TGF beta, TGFbeta Signaling
+ down-regulates activity img/direct_inhibition.png binding SMAD2 0.73
Publications: 2 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates activity img/indirect-activation.png unknown LEF1 0.37
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination SMAD2 0.36
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
Pathways:T-Lymphocyte: IL6
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD2
Publications: 1 Organism: Homo Sapiens
Tissue: HEK-293 Cell
Pathways:TGFbeta Signaling
+ up-regulates img/direct-activation.png binding SMAD2 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deubiquitination SMAD2 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding SMAD2 0.18
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.16
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates activity img/direct-activation.png binding SMAD2 0.70
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SMAD2 0.18
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown SMAD2 0.40
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD2 0.66
Publications: 1 Organism: Homo Sapiens
Tissue: HEK-293 Cell
+ down-regulates activity img/direct_inhibition.png binding SMAD2 0.73
Publications: 2 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates img/direct-activation.png binding CREB1 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD4 1.00
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: BMP, Macrophage: TGF beta, Myostatin, Satellite: atrophy, TGFbeta Signaling
+ form complex img/form-complex.png binding SMAD2/SMAD4
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage: TGF beta, Satellite: atrophy, TGFbeta Signaling
+ up-regulates img/direct-activation.png ubiquitination SMAD2 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown SMAD2 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: BMP
+ down-regulates img/indirect_inhibition.png unknown SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination SMAD2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:Myostatin
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization SMAD2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.13
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SMAD2/SMURF2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.30
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates activity img/direct-activation.png binding SMURF2 0.66
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD2 0.36
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png unknown SMAD2 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMAD2 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD2
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: BMP, Macrophage: TGF beta, Myostatin, Satellite: atrophy, TGFbeta Signaling, T-Lymphocyte: IL6, T-Lymphocyte: TGF beta
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2 0.25
Publications: 1 Organism: Mus Musculus
Pathways:Myostatin, Satellite: atrophy
+ form complex img/form-complex.png binding SMAD2/STAT3/EP300
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMAD2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD2 0.51
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD2 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD2 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD2 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deubiquitination SMAD2 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2 0.51
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MEF2A 0.35
Publications: 1 Organism: Mus Musculus
Tissue: Myotube
+ up-regulates img/direct-activation.png binding SMAD2 0.21
Publications: 1 Organism: Homo Sapiens