Pathway ID: SIGNOR-ACView in NDEx

Description: The transition from precursor stem cells into mature adipocytes is a very complex and highly controlled process. Several molecules, pathways and signals are required to accomplish this orchestrated programme. Multiple signals can influence whether stem cells form adipocytes, including extracellular factors such as the bone morphogenetic proteins (BMP 2/4/7), insulin (INS) and hormones (Glucocorticoids). All these factors activate the Peroxisome proliferator-activated receptor gamma (PPARG), that promotes the maturation of adipocytes.

Curated by: Filomena Spada

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

29 Seed Entities

Name Primary ID
AKT1 P31749
TGFBR1 P36897
CREB1 P16220
TGFB1 P01137
NR3C1 P04150
SOS1 Q07889
GSK3B P49841
KLF5 Q13887
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate CHEBI:16618
RPS6KA5 O75582
SMAD3 P84022
CDK2 P24941
KRAS P01116
GATA2 P23769
INSR P06213
GRB2 P62993
INS P01308
IRS1 P35568
RAF1 P04049
Adipogenesis SIGNOR-PH26
CEBPA P49715
FOXO1 Q12778
CEBPB P17676
PPARG P37231
PDPK1 O15530
PIK3CB P42338
CEBPD P49716