Summary

Name PRKCZ
Full Name Protein kinase C zeta type
Synonyms nPKC-zeta | PKC2
Primary ID Q05513
Links - -
Type protein
Relations 61
Function Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation AQP9 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.716
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATP1A1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IKBKB 0.49
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PIAS4 0.497
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation BAX 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYH10 0.273
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1 0.404
Publications: 8 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.716
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png phosphorylation STK11 0.325
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Smooth Muscle
+ up-regulates img/direct-activation.png phosphorylation RELA 0.531
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.716
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT (isoform 2) 0.273
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PSEN1 0.342
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STK11 0.325
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT3 0.524
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
+ img/unknown.png phosphorylation TRAF2 0.405
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHAT 0.291
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NREP 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SP1 0.501
Publications: 5 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation ADD2 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ADD1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation PARD3 0.697
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.376
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.574
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation WWC1 0.732
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation YWHAB 0.375
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation AKT2 0.474
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation HABP4 0.295
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R14A 0.281
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCZ 0.553
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NR1H4 0.394
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS3 0.384
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP1LC3B 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PRKCZ 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MARK3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MARK2 0.27
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MGluR 0.389
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation NfKb-p65/p50 0.471
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation PRKCZ 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PRKCZ 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation PRKCZ 0.8
Publications: 1 Organism: Homo Sapiens