Summary

Name TRAF2
Full Name TNF receptor-associated factor 2
Synonyms E3 ubiquitin-protein ligase TRAF2, Tumor necrosis factor type 2 receptor-associated protein 3 | TRAP3
Primary ID Q12933
Links - -
Type protein
Relations 46
Pathways Inhibition of Apoptosis, Macrophage: TNF alpha, Multiple sclerosis, NF-KB Canonical, NF-KB Non Canonical, P38 Signaling, SAPK/JNK Signaling, Satellite: TNFA, TNF-alpha Signaling, Tnfa_Notch_crosstalk
Function Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination MAP3K7 0.575
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, P38 Signaling, SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png ubiquitination, binding RIPK1 0.889
Publications: 6 Organism: Homo Sapiens, Mus Musculus
Pathways:Multiple sclerosis, NF-KB Canonical, SAPK/JNK Signaling, TNF-alpha Signaling
+ img/unknown.png phosphorylation TRAF2 0.405
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TRAF2 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation TRAF2 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png binding, ubiquitination MAP3K14 0.564
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:NF-KB Non Canonical
+ up-regulates img/direct-activation.png binding BIRC3 0.886
Publications: 5 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ up-regulates img/direct-activation.png TRAF2 0.826
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, P38 Signaling, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png ubiquitination TRAF2 0.44
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical
+ up-regulates activity img/direct-activation.png binding BIRC2 0.867
Publications: 2 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ up-regulates activity img/direct-activation.png binding TRAF2 0.864
Publications: 3 Organism: Mus Musculus, Homo Sapiens
Pathways:Inhibition of Apoptosis, NF-KB Canonical, P38 Signaling, TNF-alpha Signaling
+ up-regulates img/direct-activation.png binding TRAF2 0.612
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates img/direct-activation.png binding MAP3K1 0.7
Publications: 2 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png binding MAP3K5 0.726
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, TNF-alpha Signaling
+ up-regulates img/direct-activation.png RIPK1 0.889
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis, NF-KB Canonical, SAPK/JNK Signaling, TNF-alpha Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TRAF2 0.867
Publications: 2 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ up-regulates activity img/direct-activation.png binding TRAF2 0.836
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis, NF-KB Non Canonical
+ down-regulates activity img/direct_inhibition.png deubiquitination TRAF2 0.661
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ up-regulates activity img/direct-activation.png ubiquitination TRAF2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TRAF1 0.612
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png binding TRAF2 0.665
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding TRAF2 0.717
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding TRAF2 0.563
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ up-regulates activity img/direct-activation.png binding MAP3K14 0.564
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRAF2 0.514
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png polyubiquitination TICAM1 0.442
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TRAF2 0.696
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TRAF2 0.886
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ up-regulates img/direct-activation.png binding MAP4K2 0.509
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png binding UBE2N 0.44
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , NF-KB Canonical