| + |
STK4 | up-regulates 
phosphorylation
|
FOXO3 |
0.678 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178190 |
Ser209 |
SSAGWKNsIRHNLSL |
Homo sapiens |
|
| pmid |
sentence |
| 18394876 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191851 |
Ser209 |
SSAGWKNsIRHNLSL |
Homo sapiens |
|
| pmid |
sentence |
| 22898666 |
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPKAPK5 | up-regulates activity
phosphorylation
|
FOXO3 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279469 |
Ser215 |
NSIRHNLsLHSRFMR |
Homo sapiens |
|
| pmid |
sentence |
| 21329882 |
Analysis of mutant alleles of FoxO3a showed that MK5 phosphorylated FoxO3a predominantly at S215, but that mutation of four of the identified sites was required to essentially abolish phosphorylation of FoxO3a by MK5 (\u201c4A\u201d) ( Figure\u00a04 C and data not shown).|MK5 phosphorylates and activates the transcription factor FoxO3a and potentially other FoxO factors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | down-regulates quantity by destabilization 
phosphorylation
|
FOXO3 |
0.908 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249626 |
Ser253 |
APRRRAVsMDNSNKY |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249627 |
Ser315 |
DFRSRTNsNASTVSG |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249625 |
Thr32 |
QSRPRSCtWPLQRPE |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Publications: |
3 |
| Pathways: | IGF and Myogenesis |
| + |
PIM | down-regulates
phosphorylation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259429 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
Pim-mediated phosphorylation and inactivation of forkhead transcription factors, foxo1a and foxo3a, was involved in the transcriptional repression of the p27(kip1) gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3 in AML |
| + |
AKT | down-regulates quantity by destabilization
phosphorylation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249646 |
Ser253 |
APRRRAVsMDNSNKY |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249647 |
Ser315 |
DFRSRTNsNASTVSG |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249645 |
Thr32 |
QSRPRSCtWPLQRPE |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Publications: |
3 |
| Pathways: | FLT3 in AML, AMPK Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Thyroid cancer |
| + |
SGK1 | down-regulates activity
phosphorylation
|
FOXO3 |
0.791 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249133 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 11154281 |
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236607 |
Ser315 |
DFRSRTNsNASTVSG |
Homo sapiens |
|
| pmid |
sentence |
| 11154281 |
We show here that sgk1, like akt, promotes cell survival and that it does so in part by phosphorylating and inactivating fkhrl1. However, sgk and akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on fkhrl1. While both kinases can phosphorylate thr-32, sgk displays a marked preference for ser-315 whereas akt favors ser-253. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249134 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 11154281 |
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Insulin Signaling |
| + |
SGK2 | down-regulates activity
phosphorylation
|
FOXO3 |
0.519 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249130 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 11154281 |
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249132 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 11154281 |
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT2 | down-regulates activity
phosphorylation
|
FOXO3 |
0.746 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236671 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235960 |
Ser315 |
DFRSRTNsNASTVSG |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236675 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PIM1 | down-regulates
phosphorylation
|
FOXO3 |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179304 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
Pim-mediated phosphorylation and inactivation of forkhead transcription factors, foxo1a and foxo3a, was involved in the transcriptional repression of the p27(kip1) gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3 in AML |
| + |
AKT | down-regulates activity
phosphorylation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183612 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183616 |
Ser315 |
DFRSRTNsNASTVSG |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183620 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261526 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14981546 |
Phosphorylation of Foxo proteins through FLT3-ITD signaling promotes their translocation from the nucleus into the cytoplasm, which requires the presence of conserved Akt phosphorylation sites in Forkhead transcription factors and PI3K activity. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | FLT3 in AML, AMPK Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Thyroid cancer |
| + |
AKT3 | down-regulates
phosphorylation
|
FOXO3 |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183644 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183648 |
Ser315 |
DFRSRTNsNASTVSG |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183652 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | up-regulates
dephosphorylation
|
FOXO3 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163680 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 20110348 |
Protein phosphatase 2a reactivates foxo3a through a dynamic interplay with 14-3-3 and aktpp2a-mediated dephosphorylation of t32/s253 is required for dissociation of 14-3-3, nuclear translocation, and transcriptional activation of foxo3a. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163684 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 20110348 |
Protein phosphatase 2a reactivates foxo3a through a dynamic interplay with 14-3-3 and aktpp2a-mediated dephosphorylation of t32/s253 is required for dissociation of 14-3-3, nuclear translocation, and transcriptional activation of foxo3a. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SGK3 | down-regulates activity
phosphorylation
|
FOXO3 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249135 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 11154281 |
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT2 | down-regulates quantity by destabilization
phosphorylation
|
FOXO3 |
0.746 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249640 |
Ser253 |
APRRRAVsMDNSNKY |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249641 |
Ser315 |
DFRSRTNsNASTVSG |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249639 |
Thr32 |
QSRPRSCtWPLQRPE |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Publications: |
3 |
| + |
AKT1 | down-regulates activity
phosphorylation
|
FOXO3 |
0.908 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252522 |
Ser253 |
APRRRAVsMDNSNKY |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252523 |
Ser315 |
DFRSRTNsNASTVSG |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252524 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175288 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Akt inactivates protein degradation by phosphorylating and thus repressing the transcription factors of the foxo family, and stimulates protein synthesis via the mammalian target of rapamycin (mtor) and glycogen synthase kinase 3b (gsk3b). |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
AKT3 | down-regulates quantity by destabilization
phosphorylation
|
FOXO3 |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249643 |
Ser253 |
APRRRAVsMDNSNKY |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249644 |
Ser315 |
DFRSRTNsNASTVSG |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249642 |
Thr32 |
QSRPRSCtWPLQRPE |
|
|
| pmid |
sentence |
| 19951971 |
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation. |
|
| Publications: |
3 |
| + |
MAPK1 | down-regulates quantity by destabilization
phosphorylation
|
FOXO3 |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160407 |
Ser294 |
QLSKWPGsPTSRSSD |
Homo sapiens |
|
| pmid |
sentence |
| 18204439 |
Here, we show that erk downregulates forkhead box o 3a (foxo3a) by directly interacting with and phosphorylating foxo3a at ser 294, ser 344 and ser 425, which consequently promotes cell proliferation and tumorigenesisMDM2 is required for ERk-mediated FOXO3a degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160411 |
Ser344 |
QDDDAPLsPMLYSSS |
Homo sapiens |
|
| pmid |
sentence |
| 18204439 |
Here, we show that erk downregulates forkhead box o 3a (foxo3a) by directly interacting with and phosphorylating foxo3a at ser 294, ser 344 and ser 425, which consequently promotes cell proliferation and tumorigenesisMDM2 is required for ERk-mediated FOXO3a degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160415 |
Ser425 |
TKGSGLGsPTSSFNS |
Homo sapiens |
|
| pmid |
sentence |
| 18204439 |
Here, we show that erk downregulates forkhead box o 3a (foxo3a) by directly interacting with and phosphorylating foxo3a at ser 294, ser 344 and ser 425, which consequently promotes cell proliferation and tumorigenesisMDM2 is required for ERk-mediated FOXO3a degradation. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates quantity by destabilization
phosphorylation
|
FOXO3 |
0.589 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184569 |
Ser294 |
QLSKWPGsPTSRSSD |
Homo sapiens |
|
| pmid |
sentence |
| 19282669 |
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184573 |
Ser344 |
QDDDAPLsPMLYSSS |
Homo sapiens |
|
| pmid |
sentence |
| 19282669 |
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184577 |
Ser425 |
TKGSGLGsPTSSFNS |
Homo sapiens |
|
| pmid |
sentence |
| 19282669 |
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1 | down-regulates
phosphorylation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163672 |
Ser318 |
SRTNSNAsTVSGRLS |
Homo sapiens |
|
| pmid |
sentence |
| 20110348 |
Casein kinase (ck) 1 mediates the hierarchical phosphorylation of foxo3a at s318 and s321, which like foxo1 (rena et al., 2002 blue right-pointing triangle, 2004 blue right-pointing triangle), is probably to enhance its rate of nuclear export |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163676 |
Ser321 |
NSNASTVsGRLSPIM |
Homo sapiens |
|
| pmid |
sentence |
| 20110348 |
Casein kinase (ck) 1 mediates the hierarchical phosphorylation of foxo3a at s318 and s321, which like foxo1 (rena et al., 2002 blue right-pointing triangle, 2004 blue right-pointing triangle), is probably to enhance its rate of nuclear export |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183661 |
|
|
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CDK6 | up-regulates activity
phosphorylation
|
FOXO3 |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279023 |
Ser325 |
STVSGRLsPIMASTE |
Homo sapiens |
|
| pmid |
sentence |
| 28778953 |
CDK6 and cyclin D3 complex phosphorylates FOXO3 on S325.|Using cycloheximide (CHX), we observed that CDK6 knockdown decreased FOXO3 stability, particularly in platinum treated cells (Fig XREF_FIG A) and that, following platinum treatment, FOXO3 WT was more stable than the non phosphorylatable mutant FOXO3 S325A (Fig XREF_FIG B). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DYRK1A | down-regulates
phosphorylation
|
FOXO3 |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183674 |
Ser330 |
RLSPIMAsTELDEVQ |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity phosphorylation of foxos by akt, ikk, erk, ck1, cdk2, and dyrk1a universally leads to foxo's inhibition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DYRK1A | down-regulates activity
phosphorylation
|
FOXO3 |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106833 |
Ser330 |
RLSPIMAsTELDEVQ |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity phosphorylation of foxos by akt, ikk, erk, ck1, cdk2, and dyrk1a universally leads to foxo's inhibition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | up-regulates activity
phosphorylation
|
FOXO3 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274095 |
Ser399 |
DNITLPPsQPSPTGG |
in vitro |
|
| pmid |
sentence |
| 17711846 |
Here, we find that AMPK directly regulates mammalian FOXO3, a member of the FOXO family of Forkhead transcription factors known to promote resistance to oxidative stress, tumor suppression, and longevity. We show that AMPK phosphorylates human FOXO3 at six previously unidentified regulatory sites.Phosphorylation by AMPK leads to the activation of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.Taken together, these results indicate that AMPK phosphorylates at least six residues of FOXO3 in vitro (Thr179, Ser399, Ser413, Ser555, Ser588, and Ser626). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249668 |
Ser399 |
DNITLPPsQPSPTGG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249678 |
Ser413 |
GLMQRSSsFPYTTKG |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255756 |
Ser413 |
GLMQRSSsFPYTTKG |
Mus musculus |
|
| pmid |
sentence |
| 22848740 |
When AMPK is stimulated, pre-existing FOXO3 becomes reverted toward an active form. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274098 |
Ser413 |
GLMQRSSsFPYTTKG |
in vitro |
|
| pmid |
sentence |
| 17711846 |
Here, we find that AMPK directly regulates mammalian FOXO3, a member of the FOXO family of Forkhead transcription factors known to promote resistance to oxidative stress, tumor suppression, and longevity. We show that AMPK phosphorylates human FOXO3 at six previously unidentified regulatory sites.Phosphorylation by AMPK leads to the activation of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.Taken together, these results indicate that AMPK phosphorylates at least six residues of FOXO3 in vitro (Thr179, Ser399, Ser413, Ser555, Ser588, and Ser626). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274093 |
Ser555 |
RALSNSVsNMGLSES |
in vitro |
|
| pmid |
sentence |
| 17711846 |
Here, we find that AMPK directly regulates mammalian FOXO3, a member of the FOXO family of Forkhead transcription factors known to promote resistance to oxidative stress, tumor suppression, and longevity. We show that AMPK phosphorylates human FOXO3 at six previously unidentified regulatory sites.Phosphorylation by AMPK leads to the activation of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.Taken together, these results indicate that AMPK phosphorylates at least six residues of FOXO3 in vitro (Thr179, Ser399, Ser413, Ser555, Ser588, and Ser626). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249682 |
Ser555 |
RALSNSVsNMGLSES |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249685 |
Ser588 |
QTLSDSLsGSSLYST |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274096 |
Ser588 |
QTLSDSLsGSSLYST |
in vitro |
|
| pmid |
sentence |
| 17711846 |
Here, we find that AMPK directly regulates mammalian FOXO3, a member of the FOXO family of Forkhead transcription factors known to promote resistance to oxidative stress, tumor suppression, and longevity. We show that AMPK phosphorylates human FOXO3 at six previously unidentified regulatory sites.Phosphorylation by AMPK leads to the activation of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.Taken together, these results indicate that AMPK phosphorylates at least six residues of FOXO3 in vitro (Thr179, Ser399, Ser413, Ser555, Ser588, and Ser626). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249688 |
Ser626 |
SLECDMEsIIRSELM |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274097 |
Ser626 |
SLECDMEsIIRSELM |
in vitro |
|
| pmid |
sentence |
| 17711846 |
Here, we find that AMPK directly regulates mammalian FOXO3, a member of the FOXO family of Forkhead transcription factors known to promote resistance to oxidative stress, tumor suppression, and longevity. We show that AMPK phosphorylates human FOXO3 at six previously unidentified regulatory sites.Phosphorylation by AMPK leads to the activation of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.Taken together, these results indicate that AMPK phosphorylates at least six residues of FOXO3 in vitro (Thr179, Ser399, Ser413, Ser555, Ser588, and Ser626). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274094 |
Thr179 |
SSPDKRLtLSQIYEW |
in vitro |
|
| pmid |
sentence |
| 17711846 |
Here, we find that AMPK directly regulates mammalian FOXO3, a member of the FOXO family of Forkhead transcription factors known to promote resistance to oxidative stress, tumor suppression, and longevity. We show that AMPK phosphorylates human FOXO3 at six previously unidentified regulatory sites.Phosphorylation by AMPK leads to the activation of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.Taken together, these results indicate that AMPK phosphorylates at least six residues of FOXO3 in vitro (Thr179, Ser399, Ser413, Ser555, Ser588, and Ser626). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238813 |
Thr179 |
SSPDKRLtLSQIYEW |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216481 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17900900 |
We have recently found that AMPK phosphorylates human FOXO3 in mammalian cells at novel regulatory sites that are distinct from the AKT sites |
|
| Publications: |
14 |
Organism: |
In Vitro, Homo Sapiens, Mus Musculus |
| Pathways: | AMPK Signaling |
| + |
PRKAA1 | up-regulates activity
phosphorylation
|
FOXO3 |
0.514 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249667 |
Ser399 |
DNITLPPsQPSPTGG |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249677 |
Ser413 |
GLMQRSSsFPYTTKG |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249681 |
Ser555 |
RALSNSVsNMGLSES |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249684 |
Ser588 |
QTLSDSLsGSSLYST |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249687 |
Ser626 |
SLECDMEsIIRSELM |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238804 |
Thr179 |
SSPDKRLtLSQIYEW |
Homo sapiens |
|
| pmid |
sentence |
| 17711846 |
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255755 |
|
|
|
|
| pmid |
sentence |
| 22848740 |
When AMPK is stimulated, pre-existing FOXO3 becomes reverted toward an active form. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219247 |
|
|
Caenorhabditis elegans |
|
| pmid |
sentence |
| 17900900 |
The energy sensor amp-activated protein kinase (ampk) has been shown to directly phosphorylate foxo factors at six regulatory sites that are distinct from the akt. |
|
| Publications: |
8 |
Organism: |
Homo Sapiens, , Caenorhabditis Elegans |
| + |
MAPK8 | up-regulates activity
phosphorylation
|
FOXO3 |
0.645 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280030 |
Ser574 |
SAKHQQQsPVSQSMQ |
Homo sapiens |
|
| pmid |
sentence |
| 27669435 |
As JNK1 phosphorylates FOXO3 at S574, 12 allowing formation of the proapoptotic species, we tested whether FOXO3 acetylation is required for the JNK1-FOXO3 interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHUK | down-regulates
phosphorylation
|
FOXO3 |
0.571 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124203 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
|
| pmid |
sentence |
| 15084260 |
Ikappab kinase promotes tumorigenesis through inhibition of forkhead foxo3a. The tnf treatment of ht-29 cells increased ikk-dependent foxo3 ser644 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE | down-regulates
phosphorylation
|
FOXO3 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202054 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
|
| pmid |
sentence |
| 23691078 |
Ikbke phosphorylation and inhibition of foxo3a: a mechanism of ikbke oncogenic functionhere we report that ikbke regulates foxo3a through phosphorylation of foxo3a-ser644. The phosphorylation of foxo3a resulted in its degradation and nuclear-cytoplasmic translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKB | down-regulates
phosphorylation
|
FOXO3 |
0.692 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183684 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124207 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15084260 |
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
IKK-complex | down-regulates
phosphorylation
|
FOXO3 |
0.541 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216407 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
|
| pmid |
sentence |
| 15084260 |
Ikappab kinase promotes tumorigenesis through inhibition of forkhead foxo3a. The tnf treatment of ht-29 cells increased ikk-dependent foxo3 ser644 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inhibition of Apoptosis |
| + |
IKK-complex | down-regulates quantity by destabilization
phosphorylation
|
FOXO3 |
0.541 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209769 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
|
| pmid |
sentence |
| 19188143 |
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inhibition of Apoptosis |
| + |
MAPK14 | up-regulates
phosphorylation
|
FOXO3 |
0.516 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177927 |
Ser7 |
sPAPLSPL |
Homo sapiens |
|
| pmid |
sentence |
| 22128155 |
Ogether, our results suggest that p38 phosphorylation of foxo3a on ser-7 is essential for its nuclear relocalization in response to doxorubicin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIM | down-regulates activity
phosphorylation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259428 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
Pim1s expression induced the phosphorylation of foxo3a (fig. 5a and b) and inactivated its transcriptional activity (fig. 5c). A previous report showed that phosphorylation at t32, s253, and s315 residues in foxo3a induced 14-3-3 binding, nuclear export, and proteasomemediated degradation (42). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3 in AML |
| + |
PPP2CA | up-regulates activity
dephosphorylation
|
FOXO3 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163688 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 20110348 |
Pp2a-mediated dephosphorylation of t32/s253 is required for dissociation of 14-3-3, nuclear translocation, and transcriptional activation of foxo3a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIM1 | down-regulates activity
phosphorylation
|
FOXO3 |
0.39 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179308 |
Thr32 |
QSRPRSCtWPLQRPE |
Homo sapiens |
|
| pmid |
sentence |
| 18593906 |
Pim1s expression induced the phosphorylation of foxo3a (fig. 5a and b) and inactivated its transcriptional activity (fig. 5c). A previous report showed that phosphorylation at t32, s253, and s315 residues in foxo3a induced 14-3-3 binding, nuclear export, and proteasomemediated degradation (42). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3 in AML |
| + |
FOXO3 | up-regulates quantity by expression 
transcriptional regulation
|
FBXO32 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232174 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15109499 |
Moreover, constitutively active Foxo3 acts on the atrogin-1 promoter to cause atrogin-1 transcription and dramatic atrophy of myotubes and muscle fibers. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252070 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 15109499 |
Constitutively active Foxo3 acts on the atrogin-1 promoter to cause atrogin-1 transcription and dramatic atrophy of myotubes and muscle fibers |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235715 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Mus Musculus |
| Tissue: |
Muscle |
| Pathways: | IGF and Myogenesis |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
FASLG |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-66035 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10102273 |
Within the nucleus, fkhrl1 triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the fas ligand gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity
transcriptional regulation
|
FOXO3 |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255759 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22848740 |
We show that FOXO3 is an immediate early glucocorticoid receptor (GR) target, whose transcription is even further enhanced by conditions that mimic metabolic stress. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO3 | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256645 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
TSC22D3 |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255950 |
|
|
Mus musculus |
CTLL-2 Cell |
| pmid |
sentence |
| 15705665 |
We have analyzed the promoter of human gilz (glucocorticoid-induced leucine zipper), a dexamethasone-inducible gene that is involved in regulating apoptosis, and identified six glucocorticoid (GC)-responsive elements and three Forkhead responsive elements (FHREs). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO3 | down-regulates quantity
transcriptional regulation
|
STK11 |
0.628 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255758 |
|
|
|
|
| pmid |
sentence |
| 22848740 |
SGK-1 Negatively Regulates LKB1 Expression via FOXO3 Transcription Factor |
|
| Publications: |
1 |
| Pathways: | AMPK Signaling |
| + |
FOXO3 | down-regulates quantity 
transcriptional regulation
|
NOTCH |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254320 |
|
|
Mus musculus |
Satellite Cell |
| pmid |
sentence |
| 24749067 |
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO3 | down-regulates quantity
transcriptional regulation
|
NOTCH1 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244076 |
|
|
Mus musculus |
Satellite Cell |
| pmid |
sentence |
| 24749067 |
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARGC1A | down-regulates
|
FOXO3 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186058 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19491292 |
Nuclear pgc-1alpha and foxo3a respond in a reciprocal manner following aicar treatment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling |
| + |
FLT3 | down-regulates activity
|
FOXO3 |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261523 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14981546 |
Immunoblot analysis indicated an increased level of Foxo3a phosphorylation on residue Thr32, as shown by the appearance of additional slower-migrating phospho-species immediately after induction of FLT3-ITD4 expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | FLT3 in AML |
| + |
FOXO3 | up-regulates
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241949 |
|
|
Mus musculus |
Skeletal Muscle |
| pmid |
sentence |
| 15109499 |
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO3 | up-regulates quantity
transcriptional regulation
|
TSC1 |
0.446 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259382 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20371605 |
FoxO3a binds to and transactivates the TSC1 promoter, indicating a key role for FoxO3a in regulating TSC1 expression. Together, these data demonstrate that FoxO3a regulates glycolysis downstream of Akt through transcriptional control of Tsc1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Insulin Signaling |
| + |
HDAC1 | up-regulates activity
deacetylation
|
FOXO3 |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256486 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24463822 |
The ability of HDAC1 to cause muscle atrophy required its deacetylase activity and was linked to the induction of several atrophy genes by HDAC1, including atrogin-1, which required deacetylation of FoxO3a |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
DIO |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270245 |
|
|
|
|
| pmid |
sentence |
| 20978344 |
Forkhead box O3 (FoxO3) was identified as a key molecule inducing D2 expression and thereby increasing intracellular T3 production. Accordingly, FoxO3-depleted primary myoblasts also had a differentiation deficit that could be rescued by high levels of T3. |
|
| Publications: |
1 |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
CITED2 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160127 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 18158893 |
Foxo3a induces expression of cited2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
IDH1 |
0.247 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260089 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260100 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25648147 |
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates activity
deacetylation
|
FOXO3 |
0.91 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217972 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24003218 |
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122408 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | AMPK Signaling |
| + |
PPARGC1A | down-regulates quantity by repression
transcriptional regulation
|
FOXO3 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217966 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20404331 |
Capacity of PGC-1alpha and PGC-1beta to inhibit FoxO3 and NFkappaB actions and proteolysis helps explain how exercise prevents muscle atrophy.overexpression of PGC-1_ inhibits muscle wasting induced by denervation, starvation, and even caFoxO3 expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | AMPK Signaling |
| + |
FOXO3 | down-regulates quantity by repression
transcriptional regulation
|
BCL2L11 |
0.766 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261528 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14981546 |
Induction of Foxo3a phosphorylation by FLT3-ITD receptors in Ba/F3 cells correlates with the suppression of Foxo-target genes p27Kip1 and the proapoptotic Bcl-2 family member Bim |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Inhibition of Apoptosis |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
DIO2 |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256204 |
|
|
|
|
| pmid |
sentence |
| 20978344 |
Forkhead box O3 (FoxO3) was identified as a key molecule inducing D2 expression and thereby increasing intracellular T3 production. Accordingly, FoxO3-depleted primary myoblasts also had a differentiation deficit that could be rescued by high levels of T3. |
|
| Publications: |
1 |
| + |
SIRT1 | up-regulates activity
deacetylation
|
FOXO3 |
0.91 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122405 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling |
| + |
FOXO3 | up-regulates quantity
transcriptional regulation
|
RBL2 |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238606 |
|
|
Homo sapiens |
NIH-3T3 Cell |
| pmid |
sentence |
| 11884591 |
Here we show that the Forkheads AFX (FOXO4) and FKHR-L1 (FOXO3a) also directly control transcription of the retinoblastoma-like p130 protein and cause upregulation of p130 protein expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | down-regulates quantity by repression
transcriptional regulation
|
CDKN1B |
0.743 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261527 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14981546 |
Induction of Foxo3a phosphorylation by FLT3-ITD receptors in Ba/F3 cells correlates with the suppression of Foxo-target genes p27Kip1 and the proapoptotic Bcl-2 family member Bim |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Integrin Signaling |
| + |
PLK1 | down-regulates activity
phosphorylation
|
FOXO3 |
0.491 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279095 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26280018 |
Furthermore, PLK1 can directly phosphorylate FOXO3 in an in vitro kinase assay.|PLK1 induces translocation of FOXO3 from the nucleus to the cytoplasm and suppresses FOXO3 activity, measured by the decrease in the pro-apoptotic Bim protein levels and in the cell cycle inhibitor protein p27. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNA13 | up-regulates activity
phosphorylation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278050 |
|
|
Homo sapiens |
U-118MG Cell |
| pmid |
sentence |
| 37392861 |
Our results demonstrate that GNA13 expression is negatively correlated with GBM and can suppress tumor metastasis by inhibiting the ERKs signaling pathway and upregulating FOXO3 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TSC22D3 | down-regulates activity
relocalization
|
FOXO3 |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256147 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20018851 |
GILZ inhibits FOXO1, FOXO3, and FOXO4 transcriptional activities measured with natural or synthetic FOXO-responsive promoters in HL-60 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TYRO3 | down-regulates activity
phosphorylation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21291561 |
However, the present study in tPA and NMDA treated neurons establishes the link between PS mediated activation of Tyro3 and FKHRL1 phosphorylation which inactivates pro apoptotic FKHRL1 and mediates PS 's beneficial effects.|We also show that inhibition of the extrinsic apoptotic cascade by PS requires Tyro3 mediated phosphorylation of FKHRL1 which in turn inhibits FasL production and FasL dependent caspase-8 activation in the extrinsic pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
TRIM63 |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21798082 |
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | IGF and Myogenesis |
| + |
FOXS1 | down-regulates quantity by repression
transcriptional regulation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261610 |
|
|
Bos taurus |
|
| pmid |
sentence |
| 18288644 |
Fkhl18 suppressed the transcriptional activity of FoxO3a and FoxO4. |
|
| Publications: |
1 |
Organism: |
Bos Taurus |
| + |
14-3-3 | down-regulates
binding
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183608 |
|
|
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell |
| pmid |
sentence |
| 19188143 |
In this study, we demonstrate that akt also regulates the activity of fkhrl1, a member of the forkhead family of transcription factors. In the presence of survival factors, akt phosphorylates fkhrl1, leading to fkhrl1's association with 14-3-3 proteins and fkhrl1's retention in the cytoplasm. Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-15849 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 1010227 |
Progressive increase in akt activation during prostate cancer progression led to increase phosphorylation of foxo3a and binding with 14-3-3, which potentially affected its transcriptional activity in age-specific manner. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MELK | down-regulates quantity
phosphorylation
|
FOXO3 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279375 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28938528 |
Further analysis indicated that FOXO1 and FOXO3, two known transcriptional regulators of p21, were phosphorylated by MELK and thus be involved in the induction of p21 after MELK inhibition.|Our findings revealed that siRNA mediated MELK knockdown increased protein levels of FOXO1 and FOXO3, which might increase p21 transcriptional level in a p53 independent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates activity
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261952 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22931788 |
Forkhead box O (FOXO) transcriptional protein family members, including FOXO1 and FOXO3, are involved in the modulation of autophagy. However, whether there is redundancy between FOXO1 and FOXO3 in the ability to induce autophagy remains unclear. In this study, we showed that FOXO3 induced a transcription-dependent autophagy, and FOXO1 was required for this process. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling |
| + |
ERK1/2 | down-regulates quantity by destabilization
phosphorylation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270175 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19282669 |
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3 in AML, AMPK Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, Thyroid cancer |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
MYOD1 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181618 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 18854138 |
Our cell-based assays and in vitro studies reveal a tight codependent partnership between foxo3 and pax3/7 to coordinately recruit rna polymerase ii and form a preinitiation complex (pic) to activate myod transcription in myoblasts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
FOXO3 | up-regulates activity
transcriptional regulation
|
TSC22D3 |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256094 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15031210 |
We then characterized the human gilz promoter and showed that FoxO3 (Forkhead box class O3) binding to the Forkhead responsive elements identified in the promoter is necessary for induction of gilz expression upon IL-2 withdrawal |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PRLR | down-regulates quantity by repression
transcriptional regulation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254187 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17975019 |
We also show that activation of RS represses the expression of the transcription factor Forkhead box O3 (FOXO3) and that of the enzyme galactose-1-phosphate uridyltransferase (Galt), two proteins known to be essential for normal follicular development. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
BCL2L11 |
0.766 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209657 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12913110 |
In addition, we find that FKHRL1 (FOXO3a) directly activates the bim promoter via two conserved FOXO binding sites and that mutation of these sites abolishes bim promoter activation after NGF withdrawal. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inhibition of Apoptosis |
| + |
FOXO3 | up-regulates quantity
transcriptional regulation
|
MIR1-1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255798 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25477897 |
The three miR-29 family members in mouse bone marrow cells reduced the level of TET2 as well as its metabolic by-product, 5hmC |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO3 | down-regulates
|
Cell_cycle_progress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267283 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SETD2 | up-regulates quantity by expression
transcriptional regulation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160201 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18158893 |
In response to hypoxia, foxo3a transcript levels accumulate in an hif1-dependent way, resulting in enhanced foxo3a activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates quantity
transcriptional regulation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255757 |
|
|
|
|
| pmid |
sentence |
| 22848740 |
We show that FOXO3 binds and activates its own promoter via a positive autoregulatory feedback loop |
|
| Publications: |
1 |
| Pathways: | FLT3 in AML, AMPK Signaling, Insulin Signaling, Inhibition of Apoptosis, Integrin Signaling, IGF and Myogenesis, Thyroid cancer |
| + |
FOXO3 | up-regulates
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217881 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer |
| + |
TEAD1 | up-regulates quantity by expression
transcriptional regulation
|
FOXO3 |
0.303 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170976 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21211055 |
Tead1 can regulate transcription of the foxo3a gene through the binding to the m-cat element, demonstrated with independent chip-pcr analysis, emsa and luciferase reporter system assay. The over-expression and inhibition analysis suggest that foxo3a was positively regulated by tead1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | down-regulates quantity by destabilization
phosphorylation
|
FOXO3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270070 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19282669 |
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates quantity
transcriptional regulation
|
CDKN1B |
0.743 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238610 |
|
|
Mus musculus |
NIH-3T3-A14 Cell |
| pmid |
sentence |
| 10783894 |
AFX transcriptionally activates p27kip1, resulting in increased protein levels. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Integrin Signaling |
| + |
FOXO3 | up-regulates quantity by expression
transcriptional regulation
|
GALT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254186 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17975019 |
Our finding that FOXO3 regulates the expression of Galt and enhances its transcriptional activity indicates that it is the repression of FOXO3 by PRL acting through RS that prevents Galt expression in the ovary and causes follicular death. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Ovary |
| + |
FOXO3 | down-regulates quantity
transcriptional regulation
|
NOTCH3 |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244079 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24749067 |
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EGLN2 | down-regulates activity
hydroxylation
|
FOXO3 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24990963 |
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.|Here we report that EglN2 can hydroxylate FOXO3a on two specific prolyl residues in vitro and in vivo. Hydroxylation of these sites prevents the binding of USP9x deubiquitinase, thereby promoting the proteasomal degradation of FOXO3a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217887 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 inhibited foxo3's ability to induce cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3 in AML, Inhibition of Apoptosis, Integrin Signaling, Thyroid cancer |
4.0
FOXO3
- 
- 