Summary

Name IL6
Full Name Interleukin-6
Synonyms IL-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2, IFN-beta-2 | IFNB2
Primary ID P05231
Links - -
Type protein
Relations 32
Pathways IL6
Function Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/indirect-activation.png unknown IL6ST 0.39
Publications: 1 Organism: In Vitro
Pathways:IL6
+ up-regulates img/direct-activation.png binding IL6R 0.62
Publications: 5 Organism: Homo Sapiens,
Tissue: Muscle, Skeletal Muscle, Brain
Pathways:IL6
+ up-regulates img/direct-activation.png binding IL6ST 0.39
Publications: 3 Organism: Homo Sapiens,
Pathways:IL6
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6 0.05
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.02
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.01
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.01
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6 0.10
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GCH1 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png unknown IL6
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation IL6
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation IL6 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation IL6
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown AMPK
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates activity img/indirect-activation.png unknown STAT3 0.43
Publications: 1 Organism: Rattus Norvegicus
Tissue: Skeletal Muscle
Pathways:IL6
+ up-regulates activity img/direct-activation.png binding IL6R 0.62
Publications: 3
Tissue: Skeletal Muscle
Pathways:IL6