Summary

Name IL10
Full Name Interleukin-10
Synonyms IL-10, Cytokine synthesis inhibitory factor, CSIF
Primary ID P22301
Links - -
Type protein
Relations 31
Pathways Macrophage polarization, Macrophage: IL10, Macrophage: Polarization and myogenesis, Multiple sclerosis, SARS-CoV CYTOKINE STORM, T-Lymphocyte: IL10
Function Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.361
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.374
Publications: 1
Pathways:Macrophage polarization
+ up-regulates activity img/direct-activation.png binding IL10RA 0.911
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN4A 0.2
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL1RN 0.597
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN1A 0.2
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN3A 0.2
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/indirect-activation.png transcriptional regulation IL10 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN2A 0.272
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN8A 0.2
Publications: 1 Organism: Rattus Norvegicus
Tissue: Spinal Ganglion
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN9A 0.2
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN11A 0.2
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png IL10 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis
+ down-regulates img/indirect_inhibition.png transcriptional regulation IL10 0.43
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.5
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IL10RA 0.911
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IL10 0.43
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.435
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IL10RB 0.702
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IL10 0.453
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png transcriptional regulation IL10 0.78
Publications: 2 Organism: Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ down-regulates quantity by repression img/indirect_inhibition.png translation regulation IL10 0.473
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN10A 0.265
Publications: 1 Organism: Rattus Norvegicus
Tissue: Spinal Ganglion
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.7
Publications: 1
Tissue: Skeletal Muscle
Pathways:Macrophage polarization, Multiple sclerosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.333
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN5A 0.2
Publications: 1 Organism: Rattus Norvegicus
Tissue: Spinal Ganglion
+ down-regulates quantity img/indirect_inhibition.png post transcriptional regulation IL10 0.473
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png IL10 0.2
Publications: 1 Organism: Mus Musculus