Summary

Name MECP2
Full Name Methyl-CpG-binding protein 2
Synonyms MeCp-2 protein, MeCp2 |
Primary ID P51608
Links - -
Type protein
Relations 44
Pathways Acute Myeloid Leukemia, miRNA in AML, Rett syndrome
Function Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation MECP2 0.495
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation GRIN2B 0.362
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation SST 0.304
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML, Rett syndrome
+ form complex img/form-complex.png binding MECP2/SIN3A/HDAC complex 0.688
Publications: 1 Organism: Rattus Norvegicus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SGK1 0.299
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation FKBP5 0.315
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation MET 0.276
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation DLL1 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation AMPA 0.335
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DLX5 0.392
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GAD1 0.383
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTPN1 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BDNF 0.493
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ALOX5 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PTPN1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ up-regulates img/indirect-activation.png Neuron_maturation 0.7
Publications: 1 Organism: Mus Musculus
Tissue: Hippocampus
Pathways:Rett syndrome
+ up-regulates img/indirect-activation.png Neurogenesis 0.7
Publications: 2 Organism: Mus Musculus
Tissue: Hippocampus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RELN 0.394
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MEF2C 0.358
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation MECP2 0.4
Publications: 2 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MECP2 0.358
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation GAMT 0.286
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ABCB1 0.2
Publications: 1
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation RBFOX1 0.286
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IGFBP3 0.255
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CCND1 0.278
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png binding DNMT1 0.551
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation miR-199a 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MGMT 0.314
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation BDNF 0.493
Publications: 1 Organism: Rattus Norvegicus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CRH 0.488
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation GRIA2 0.333
Publications: 1 Organism: Rattus Norvegicus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ESR1 0.405
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation OPRK1 0.278
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation GPRIN1 0.306
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ img/unknown.png phosphorylation MECP2 0.628
Publications: 1 Organism: In Vitro
Pathways:Rett syndrome
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TFF1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DEAF1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation CREB1 0.553
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NOTCH1 0.297
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, Rett syndrome