Summary

Name INS
Full Name Insulin [Cleaved into: Insulin B chain; Insulin A chain]
Synonyms INS_HUMAN
Primary ID P01308
Links - -
Type protein
Relations 29
Pathways Adipogenesis, AMPK Signaling, FAP: In vitro induction of adipogenesis, FAP: Insulin-mediated adipogenesis, FAP: INSR, GLP-1 and GIP receptor signaling in PDAC, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling, Pericyte: In vitro induction of adipogenesis
Function Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation INS 0.642
Publications: 1 Organism: Mus Musculus
Pathways:Insulin Signaling
+ down-regulates img/indirect_inhibition.png GSK3B 0.458
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Adipogenesis, Insulin Signaling, MTOR Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COMT 0.322
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation INS 0.289
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png FOXO 0.481
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png AKT1 0.752
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates img/indirect-activation.png AKT 0.752
Publications: 1 Organism: Mus Musculus
Pathways:AMPK Signaling, FAP: Insulin-mediated adipogenesis, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling
+ up-regulates img/indirect-activation.png CEBPB 0.428
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage INS 0.722
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/indirect_inhibition.png IRS1 0.679
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling
+ up-regulates activity img/indirect-activation.png LPL 0.466
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization INS 0.378
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png IRS1 0.679
Publications: 1 Organism: Rattus Norvegicus
Pathways:Adipogenesis, AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling
+ down-regulates img/indirect_inhibition.png DUSP6 0.383
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IGF1R 0.891
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png binding INSR 0.935
Publications: 2 Organism: Cricetulus Griseus, Homo Sapiens
Pathways:Adipogenesis, AMPK Signaling, FAP: Insulin-mediated adipogenesis, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling
+ up-regulates img/indirect-activation.png PIK3CG 0.336
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CEBPA 0.437
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates img/indirect_inhibition.png GATA2 0.316
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, FAP: Insulin-mediated adipogenesis
+ down-regulates activity img/indirect_inhibition.png FOXO1 0.481
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, FAP: Insulin-mediated adipogenesis, Insulin Signaling, Leptin Signaling
+ up-regulates img/indirect-activation.png RHOQ 0.287
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png TRIP10 0.267
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization INS 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation INS 0.309
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png APOB 0.476
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.49
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, FAP: Insulin-mediated adipogenesis, Leptin Signaling, MTOR Signaling
+ up-regulates activity img/indirect-activation.png SLC2A4 0.497
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:Insulin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LPL 0.466
Publications: 1 Organism: Homo Sapiens
Tissue: Adipose Tissue