| + |
CDX2 | up-regulates quantity by expression 
transcriptional regulation
|
INS |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254906 |
|
|
Homo sapiens |
BHK-21 Cell |
| pmid |
sentence |
| 12783165 |
In the heterologous cell line BHK-21, Pdx1 inhibited by 60 to 80% the activation of the alpha-cell specific element G1 conferred by Pax-6 and/or Cdx-2/3. Although Pdx1 could bind three AT-rich motifs within G1, two of which are binding sites for Pax-6 and Cdx-2/3, the affinity of Pdx1 for G1 was much lower as compared to Pax-6. In addition, Pdx1 inhibited Pax-6 mediated activation through G3, to which Pdx1 was unable to bind. Moreover, a mutation impairing DNA binding of Pdx1 had no effect on its inhibition on Cdx-2/3. Since Pdx1 interacts directly with Pax-6 and Cdx-2/3 forming heterodimers, we suggest that Pdx1 inhibits glucagon gene transcription through protein to protein interactions with Pax-6 and Cdx-2/3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | down-regulates quantity by destabilization 
|
APOB |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252114 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23721961 |
Insulin decreases ApoB secretion by promoting ApoB degradation in the hepatocyte. Though insulin does not alter ApoB mRNA levels, it inhibits ApoB translation by promoting the trafficking of ApoB mRNA into P-bodies, aggregates of translationally repressed mRNAs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PDX1 | up-regulates quantity by expression 
transcriptional regulation
|
INS |
0.662 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255541 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11309388 |
In conclusion, Pdx1 confers the expression of pancreatic β-cell-specific genes, such as genes encoding insulin, islet amyloid polypeptide, Glut2, and Nkx6.1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Insulin Signaling |
| + |
INS | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235619 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis, Leptin Signaling, MTOR Signaling |
| + |
INS | up-regulates quantity by expression
transcriptional regulation
|
LPL |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251857 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21966368 |
Insulin has a major effect on LPL regulation in adipose tissue since in mature adipocytes insulin not only increases the level of LPL mRNA but also regulates LPL activity through both posttranscriptional and posttranslational mechanisms |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Adipose Tissue |
| + |
INS | up-regulates activity
binding
|
INSR |
0.936 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236748 |
|
|
Cricetulus griseus |
|
| pmid |
sentence |
| 16956584 |
Insulin binds to the alpha subunit of the insulin receptor (IR) on the cell surface. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-23001 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2550426 |
Our previous studies indicated that amino acid residues 240-250 in the cysteine-rich region of the human insulin receptor alpha-subunit constitute a site in which insulin binds. |
|
| Publications: |
2 |
Organism: |
Cricetulus Griseus, Homo Sapiens |
| Pathways: | Adipogenesis, AMPK Signaling, FAP: Insulin-mediated adipogenesis, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling |
| + |
INS | up-regulates quantity by expression
transcriptional regulation
|
COMT |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251961 |
|
|
Homo sapiens |
Granulosa Cell |
| pmid |
sentence |
| 17612537 |
Catechol O-methyltransferase expression in granulosa cells was up-regulated by insulin, DHT, and ATRA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAPGEF4 | up-regulates quantity
relocalization
|
INS |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278140 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 24843404 |
Activation of EPAC2 has recently been shown to increase the density of insulin‐containing granules near the plasma membrane, facilitating insulin secretion from the β cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | up-regulates
|
AKT |
0.767 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97392 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12530968 |
The forkhead transcription factor foxo1 is regulated by insulin via akt-dependent phosphorylation and nuclear exclusion. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | AMPK Signaling, FAP: Insulin-mediated adipogenesis, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling |
| + |
INS | up-regulates activity
|
SLC2A4 |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236781 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9415393 |
Studies in adipose cells have demonstrated that insulin stimulates its receptor to phosphorylate tyrosine residues in irs-1, leading to activation of phosphatidylinositol 3-kinase, which plays a necessary role in mediating the translocation of the insulin-responsive glucose transporter glut4 to the cell surface. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | Insulin Signaling |
| + |
INS | up-regulates
|
CEBPB |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250565 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
INS | down-regulates activity
|
FOXO |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252952 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10358076 |
Insulin disrupts irs-dependent transactivation by fkhr, and phosphorylation of ser-256 by pkb is necessary and sufficient to mediate this effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IDE | down-regulates quantity by destabilization 
cleavage
|
INS |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260986 |
|
|
in vitro |
|
| pmid |
sentence |
| 29596046 |
IDE processively degrades insulin by stochastically cutting either chain without breaking disulfide bonds |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
INS | up-regulates
|
AKT1 |
0.767 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252627 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12530968 |
The forkhead transcription factor foxo1 is regulated by insulin via akt-dependent phosphorylation and nuclear exclusion. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
INS | up-regulates
|
RHOQ |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100483 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12687004 |
Exo70 translocates to the plasma membrane in response to insulin through the activation of tc10, where it assembles a multiprotein complex that includes sec6 and sec8 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
calcium(2+) | up-regulates quantity
relocalization
|
INS |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278144 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
| pmid |
sentence |
| 24843404 |
The increased Ca2+ concentrations eventually trigger fusion of insulin‐containing granules with the plasma membrane and insulin secretion from the β cells. Increased Ca2+ levels also promote transcription of the proinsulin gene, thereby increasing the insulin content of the β cell. Activation of EPAC2 has been shown to increase the density of insulin‐containing granules near the plasma membrane to potentiate insulin secretion from the β cell. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | down-regulates activity
|
FOXO1 |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68155 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10358076 |
Insulin disrupts irs-dependent transactivation by fkhr, and phosphorylation of ser-256 by pkb is necessary and sufficient to mediate this effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis, Insulin Signaling, Leptin Signaling |
| + |
INS | up-regulates
|
PIK3CG |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126063 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15209375 |
The interaction ofinsulin and growth factors with their receptors on the outside surface of a cell, leads to the activation of phosphatidylinositol 3-kinase (pi 3-kinase) and generation of the phosphatidylinositol 3,4,5-trisphosphate (ptdins(3,4,5)p3) second messenger at the inner surface of the cell membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PDHX | up-regulates quantity by expression
transcriptional regulation
|
INS |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254902 |
|
|
Homo sapiens |
Glucagonoma Cell |
| pmid |
sentence |
| 12783165 |
In glucagonoma cells transduced with a Pdx1-encoding lentiviral vector, insulin gene expression was induced while glucagon mRNA levels were reduced by 50 to 60%. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | up-regulates activity
|
LPL |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251858 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21966368 |
Insulin has a major effect on LPL regulation in adipose tissue since in mature adipocytes insulin not only increases the level of LPL mRNA but also regulates LPL activity through both posttranscriptional and posttranslational mechanisms |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | up-regulates
|
TRIP10 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93062 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12242347 |
The specific interaction of active tc10 with cip4 2 suggested thatinsulinmight induce a change in the subcellular localization of cip4 2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | down-regulates quantity by destabilization
|
IRS1 |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236737 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17360977 |
Research has focused on insulin receptor substrate (IRS)-1 as a locus for insulin resistance. Tyrosine phosphorylation of IRS-1 initiates insulin signaling, whereas serine/threonine phosphorylation alters the ability of IRS-1 to transduce the insulin signal. Insulin increased the phosphorylation of Ser312, Ser616, Ser636, Ser892, Ser1101, and Ser1223 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling |
| + |
INS | down-regulates
|
GATA2 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135617 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 15837948 |
We show that insulin induces gata2 phosphorylation on serine 401 in a pi-3k/akt-dependent manner. Insulin-dependent phosphorylation of serine 401 impairs gata2 translocation to the nucleus and its dna binding activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis |
| + |
INS | up-regulates
binding
|
IGF1R |
0.891 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-22083 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1851182 |
Because of the sequence homology and tertiary structure similarities between proinsulin (pi) and insulin-like growth factor-i (igf-i), it is possible that pi interacts with the igf-i receptor with higher affinity than insulin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
INS | down-regulates
|
DUSP6 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197203 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22521266 |
In conclusion,insulinlikely promotes mkp-3 protein degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | down-regulates
|
GSK3B |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37220 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8250835 |
The results suggest that ser-9 phosphorylation underlies the reported gsk3 beta inhibition by insulin and that gsk3 may represent a point of convergence of two major growth-factor-stimulated protein kinase cascades. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | Adipogenesis, Insulin Signaling, MTOR Signaling |
| + |
INS | down-regulates activity
|
IRS1 |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236625 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 15069075 |
The mechanism by which the phosphorylation of ser307 or ser318 inhibits irs-1 tyrosine phosphorylation is not known. Prolonged insulin-stimulation inhibits irs-1 binding to the phosphorylated npey motif in the juxta-membrane region of the irbeta -subunit. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Adipogenesis, AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling |
| + |
INS | up-regulates
|
CEBPA |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250570 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis |
4.0
INS
- 
- 