| + |
Caspase 1 complex | up-regulates activity 
cleavage
|
IL1B |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256376 |
Asp116 |
DNEAYVHdAPVRSLN |
in vitro |
|
| pmid |
sentence |
| 1919001 |
IL-1 converting enzyme (ICE) specifically cleaves the human IL-1 beta precursor at two sequence-related sites: Asp27-Gly28 (site 1) and Asp116-Ala117 (site 2). Cleavage at Asp116-Ala117 results in the generation of mature, biologically active IL-1 beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256375 |
Asp27 |
DDLFFEAdGPKQMKC |
in vitro |
|
| pmid |
sentence |
| 1919001 |
IL-1 converting enzyme (ICE) specifically cleaves the human IL-1 beta precursor at two sequence-related sites: Asp27-Gly28 (site 1) and Asp116-Ala117 (site 2). Cleavage at Asp116-Ala117 results in the generation of mature, biologically active IL-1 beta. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| Pathways: | COVID-19 Causal Network, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
IL1B |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251718 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 24352507 |
We finally confirmed that in the absence of HIF-1α there was a significant reduction at the protein level in pro-caspase-1, activated caspase-1, pro-IL-1β, and ultimately active IL-1β (Fig. 4g and h). These data show that adenosine induced up-regulation of IL-1β is dependent on a CREB/HIF-1α pathway which is distinct from the NF-kB pathway used for initial production of IL-1β in response to LPS. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256235 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17548584 |
The loss of macrophage expression of HIF-1 led to significant decreases in the production of TNF-a, IL-1a, IL-1b, and IL-12 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256236 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25750431 |
The results of this study show that the absence of HIFs in MPs has no impact on the resolution of inflammation in two sterile models of skeletal muscle regeneration |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| + |
IL1B | down-regulates quantity by repression 
transcriptional regulation
|
GDF5 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251864 |
|
|
Homo sapiens |
Synoviocyte |
| pmid |
sentence |
| 19818765 |
GDF-5 is suppressed by IL-1beta and enhances TGF-beta3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | up-regulates
binding
|
IL1RAP |
0.86 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-61744 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9820540 |
The recently described il-1r accessory protein (il-1r acp) interacts with il-1beta and the il-1 type-ir (il-1ri). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
UVB radiation | up-regulates 
|
IL1B |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252382 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9767234 |
UVB can stimulate the synthesis of IL-1, TNF-a and ET-1, and other cytokines by keratinocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | down-regulates 
binding
|
IL1R2 |
0.872 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-38302 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 8332913 |
Interleukin-1 (il-1) interacts with cells through two types of binding molecules, il-1 type i receptor (il-1r i) and il-1r ii. Il-1r ii inhibits il-1 activity by acting as a decoy target for il-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity
transcriptional regulation
|
IL1B |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255938 |
|
|
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 8021507 |
In these studies, we show that NF-kappa B induces transcription from the human pro-IL-1 beta (IL-1 beta) gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, IL1 Signaling , Inflammosome Activation, Multiple sclerosis, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE |
| + |
IL1B | up-regulates quantity by expression
transcriptional regulation
|
GCH1 |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252224 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10435048 |
IL-1 beta induces expression of GTP cyclohydrolase-1 which leads to increased generation of BH4 and activation of eNOS. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Vessel Endothelium |
| + |
MFGE8 | down-regulates quantity by repression
transcriptional regulation
|
IL1B |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260649 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23454767 |
We show that MFGE8 is an endogenous inhibitor of inflammasome-induced IL-1β production. MFGE8 inhibited necrotic cell–induced and ATP-dependent IL-1β production by macrophages through mediation of integrin β3 and P2X7 receptor interactions in primed cells. In conclusion, we demonstrated that MFGE8 regulates innate immunity through inhibition of inflammasome-induced IL-1β production. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IL1B | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260855 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32446778 |
Interleukin-6 (IL-6) deserves a more extensive discussion in view of its involvement in the coronavirus-induced cytokine storm. The production of this cytokine is increased by IL-1β and tumor necrosis factor (TNF- α) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL1B | up-regulates activity
binding
|
IL1R1 |
0.903 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249511 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 24166242 |
Pro-IL-1beta, mIL-1beta and mIL-beta all bind to IL-1RI, which recruits the IL-1 receptor accessory protein (IL-1RAcP) as a co-receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling , SARS-CoV CYTOKINE STORM |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
IL1B |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255355 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20219869 |
Once in the nucleus, NF-kB can induce the transcription of iNOS, TNF-alpha, and IL-1, which may then promote further NF-kB activation, as well as elevate the expression of other inflammatory mediators such as CCL2 and IL-6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | COVID-19 Causal Network, IL1 Signaling , Inflammosome Activation, Multiple sclerosis, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE |
| + |
IL1B | up-regulates
binding
|
IL1R1 |
0.903 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58122 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9625767 |
Il-1 binding to its receptor triggers a cascade of signaling events, including activation of the stress-activated mitogen-activated protein (map) kinases, c-jun nh2-terminal kinase (jnk) and p38 map kinase, as well as transcription factor nuclear factor kappab (nf-kappab). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | IL1 Signaling , SARS-CoV CYTOKINE STORM |
| + |
IL1B | up-regulates quantity by expression
transcriptional regulation
|
MC1R |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252385 |
|
|
Homo sapiens |
Melanocyte |
| pmid |
sentence |
| 9767234 |
MSH receptor (MSH-R) binding activity was upregulated by UVB, IL-1alpha, -1beta and ET-1, but was downregulated by TNF-alpha.Northern blotanalysis showed that MC1-R mRNA expression was induced 24 h after UVB irradiation in a dose-dependent manner, and that 24-h treatment with ET-1 also induced an expression of MC1-R mRNA,whereas TNF-a downregulated the expression. In addition, IL-1a and -1b have a small but real inductiveeffect on MC1-R mRNA expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | down-regulates quantity by repression
transcriptional regulation
|
DIO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267486 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells. These include TNF-a, IL-lb and INF-y. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Thyroid Hormone Metabolism |
| + |
RELA | up-regulates quantity by expression
transcriptional regulation
|
IL1B |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256237 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20975042 |
In addition, we show that the transcription of IL1B depends on a positively acting p65/c-Rel/ikbb complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | down-regulates quantity by repression
transcriptional regulation
|
KRT1 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251883 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17982242 |
IL-1β alone decreased the expression of E-cadherin and cytokeratin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | down-regulates activity
|
LPL |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251856 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1572904 |
IL-1 beta also depressed adipoconversion, inhibited markedly LPL activity, and partially reduced GPDH activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | up-regulates
|
Immune_response |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261026 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32283152 |
High levels of expression of IL-1B, IFN-γ, IP-10, and monocyte chemoattractant protein 1 (MCP-1) have been detected in patients with COVID-19. These inflammatory cytokines may activate the T-helper type 1 (Th1) cell response. Th1 activation is a key event in the activation of specific immunity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Inflammosome Activation, Multiple sclerosis, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE |
| + |
ANXA1 | up-regulates quantity by expression
transcriptional regulation
|
IL1B |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261940 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 27426034 |
Our study demonstrates that ANXA1 can be phosphorylated by PKC and is subsequently translocated to the nucleus of BV-2 microglial cells after OGD/R, resulting in the induction of pro-inflammatory cytokines. we set out to examine the relationship between the different subcellular distributions of ANXA1 and the upregulation of inflammatory cytokines. When BV-2 microglial cells were transfected with ANXA1-S27A constructs following by OGD/R treatment, the pro-inflammatory cytokines, IL-1β, IL-6, and TNF-α, were found to be expressed at lower levels than those of control groups |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IL1B | down-regulates quantity by repression
transcriptional regulation
|
DIO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267812 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells grown in TSH-containing medium. These include TNF-a, IL-lb and INF-g but not TGF-b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270241 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9397972 |
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells. These include TNF-a, IL-lb and INF-y. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus |
| + |
IL1B | up-regulates quantity by expression
transcriptional regulation
|
ITGA2 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253356 |
|
|
Homo sapiens |
MG-63 Cell |
| pmid |
sentence |
| 1744142 |
TGF-beta 1 decreases the biosynthesis of alpha 3 subunit but increases the production of alpha 2 subunit. IL-1 beta potentiates the effects of TGF-beta 1. Furthermore, in the presence of TGF-beta 1 the increase in the expression of alpha 1 subunit by IL-1 beta is even larger. Thus, IL-1 beta and TGF-beta 1, which usually have antagonistic functions in connective tissue, can regulate integrin expression in a synergistic way. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | down-regulates activity
transcriptional regulation
|
IL1B |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251736 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 23667107 |
Early Inhibition of IL-1 beta Expression by IFN-gamma Is Mediated by Impaired Binding of NF-kappa B to the IL-1 beta Promoter but Is Independent of Nitric Oxide|We report that IFN-γ suppressed bacterial RNA and LPS induced IL-1β transcription in primary murine macrophages |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
M1_polarization | up-regulates
|
IL1B |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263825 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 32454942 |
Macrophages and microglia show a high plasticity and have been arbitrarily classified into “M1” (proinflammatory) and “M2” (prorepair, anti-inflammatory) phenotypes depending on their activation state, although it is now widely accepted that this classification is hugely oversimplified, particularly for microglia, and only partially reflects the real situation. According to the M1/M2 model, M1 polarized cells are characterized by the release of proinflammatory mediators, such as TNF, IL-1β, and IFNγ |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
IL1B | down-regulates quantity by repression
transcriptional regulation
|
ENPP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252199 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7479785 |
Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes. IL-1 beta may be an important regulator of mineralization in chondrocytes by inhibiting TGF beta-induced PPi production and PC-1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | down-regulates quantity by repression
transcriptional regulation
|
ITGA3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253355 |
|
|
Homo sapiens |
MG-63 Cell |
| pmid |
sentence |
| 1744142 |
TGF-beta 1 decreases the biosynthesis of alpha 3 subunit but increases the production of alpha 2 subunit. IL-1 beta potentiates the effects of TGF-beta 1. Furthermore, in the presence of TGF-beta 1 the increase in the expression of alpha 1 subunit by IL-1 beta is even larger. Thus, IL-1 beta and TGF-beta 1, which usually have antagonistic functions in connective tissue, can regulate integrin expression in a synergistic way. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | up-regulates quantity by expression
transcriptional regulation
|
CTSK |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253316 |
|
|
|
|
| pmid |
sentence |
| 11920402 |
This is supported by our finding that inflammatory cytokines such as IL-1b and TNFa increase the expres- sion of cathepsin K mRNA 6–8-fold and increase the secretion of the mature enzyme. |
|
| Publications: |
1 |
| + |
IL1B | down-regulates quantity by repression
transcriptional regulation
|
SCNN1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251947 |
|
|
Homo sapiens |
Alveolar Epithelial Cell |
| pmid |
sentence |
| 15755725 |
Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | up-regulates activity
|
STAT3 |
0.572 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263820 |
|
|
Homo sapiens |
Helper T-lymphocyte |
| pmid |
sentence |
| 32454942 |
IL-1β, an inflammatory cytokine primarily expressed in activated macrophages, monocytes, and microglia, significantly contributes to MS development. IL-1β promotes differentiation of T cells into Th17 cells via the STAT3 pathway and thereby promotes and aggravates the inflammatory environment in the CNS |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IRF5 | up-regulates
transcriptional regulation
|
IL1B |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254510 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 21240265 |
Among the genes with differences in expression in the M1 and M2 subsets are those regulated by IRF5, including IL12A, IL12B, IL23A, IL1B, TNF, CCL3(encoding MIP-1α), RANTES, CD1A, CD40, CD86 and CCR7 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255340 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 26315890 |
IL-1b was present in the sera of wild-type mice but was not detected in the sera of IRF5-/- mice |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
Phagocytosis | down-regulates quantity
|
IL1B |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255445 |
|
|
|
Macrophage |
| pmid |
sentence |
| 22933625 |
Furthermore, phagocytosis of apoptotic neutrophils by M1 macrophages increased production of the Th2 cytokine TGFβ by the macrophages, while reducing expression of the Th1 cytokines IL-1β and TNF-α, reflecting a shift toward an M2 phenotype |
|
| Publications: |
1 |
| + |
A9/b1 integrin | up-regulates quantity by expression
transcriptional regulation
|
IL1B |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253314 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 24241034 |
Importantly, autocrine and paracrine interactions of α9β1 integrin and tenascin-C induced the expression of MMPs and IL-6 in synovial fibroblasts, as well as TNF-α and IL-1β in synovial macrophages. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1B | up-regulates quantity by expression
transcriptional regulation
|
SERPINA3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254806 |
|
|
Homo sapiens |
Astrocyte Cell Line |
| pmid |
sentence |
| 11027208 |
We characterize a molecular mechanism responsible for both IL-1 and TNF-induced expression of ACT gene in astrocytes. We identify the 5' distal IL-1/TNF-responsive enhancer of the ACT gene located 13 kb upstream of the transcription start site. This 413-bp-long enhancer contains three elements, two of which bind nuclear factor kB (NF-kB) and one that binds activating protein 1 (AP-1). All of these elements contribute to the full responsiveness of the ACT gene to both cytokines, as determined by deletion and mutational analysis. The 5' NF-kB high-affinity binding site and AP-1 element contribute most to the enhancement of gene transcription in response to TNF and IL-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IL1B
- 
- 