| + |
PDE1C | down-regulates quantity 
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253399 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22014080 |
PDE1A and PDE1B preferentially hydrolyse cGMP, whereas PDE1C hydrolyses cAMP and cGMP with similar Km values |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3',5'-cyclic AMP | down-regulates activity
chemical inhibition
|
PRKAR1A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687711 |
Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3',5'-cyclic AMP | up-regulates quantity by expression 
|
DIO2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267281 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
Dio2 is a cAMP responsive gene. Thus, any signaling pathway or molecule that increases cAMP concentration will stimulate D2 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
ADCY5 | up-regulates quantity 
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264999 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse |
| + |
ADCY4 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265006 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3',5'-cyclic AMP | down-regulates activity
chemical inhibition
|
PRKAR1B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258760 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687711 |
Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY8 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265002 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY3 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265000 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY1 | up-regulates
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152546 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
Typically Gas stimulates adenylyl cyclase and increases levels of cyclic amp (camp), whereas galfai inhibits adenylyl cyclase and lowers camp levels, and members of the galfaq family bind to and activate phospholipase c (plc), which cleaves phosphatidylinositol bisphosphate (pip2) into diacylglycerol and inositol triphosphate (ip3). The gbeta subunits and ggamma subunits function as a dimer to activate many molecules, including phospholipases, ion channels and lipid kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198486 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22863277 |
To further explore the role of camp signaling in the hippo pathway, we treated cells with forskolin, an activator of adenylyl cyclase that results in cAMP production. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Glutamatergic synapse, GABAergic synapse , Sonic Hedgehog, Neurotransmitters release, Thyroid Hormone Metabolism, WNT Signaling, WNT Signaling and Myogenesis |
| + |
ADCY10 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265008 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY2 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265004 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY6 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265001 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3',5'-cyclic AMP | up-regulates activity
chemical activation
|
PKA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258763 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687711 |
Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Dopaminergic Synapse, FLT3-ITD signaling, Glutamatergic synapse, GABAergic synapse , Nucleotide Biosynthesis, Neurotransmitters release, Oxytocin signaling, Thyroid Hormone Metabolism |
| + |
3',5'-cyclic AMP | up-regulates quantity by expression
|
DIO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270243 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
Dio2 is a cAMP responsive gene. Thus, any signaling pathway or molecule that increases cAMP concentration will stimulate D2 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Adenylate_cyclase | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267844 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11376933 |
To date, ten different mammalian isoforms of adenylyl cyclase (AC) have been cloned and characterized. Each isoform has its own distinct tissue distribution and regulatory properties, providing possibilities for different cells to respond diversely to similar stimuli. The product of the enzymatic reaction catalyzed by ACs, cyclic AMP (cAMP) has been shown to play a crucial role for a variety of fundamental physiological cell functions ranging from cell growth and differentiation, to transcriptional regulation and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis, Oxytocin signaling |
| + |
ADCY7 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265007 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADCY1 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265003 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glutamatergic synapse, GABAergic synapse , Sonic Hedgehog, Neurotransmitters release, Thyroid Hormone Metabolism, WNT Signaling, WNT Signaling and Myogenesis |
| + |
3',5'-cyclic AMP | up-regulates
chemical activation
|
PRKACA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198492 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22863277 |
The cAMP signaling cascade can activate protein kinase a (PKA) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141786 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16293724 |
Pge2 receptors are coupled to the G protein Gs, which causes accumulation of cyclic adenosine monophosphate (cAMP) and activates protein kinase a (PKA), we confirmed that PGE2 treatment or transfection of cells with the active catalytic subunit of PKA also stimulated the activity of a cAMP-responsive-element driven reporter gene (CRE-luc). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog, WNT Signaling, WNT Signaling and Myogenesis |
| + |
GNAS | up-regulates quantity
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268692 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12145344 |
HETEROTRIMERIC G PROTEINS are essential for cell signaling throughout the body. The stimulatory G protein, Gs, couples activation of a host of different transmembrane receptors to adenylyl cyclase stimulation, leading to intracellular generation of cAMP |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
| + |
ADCY9 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265005 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3',5'-cyclic AMP | down-regulates activity
chemical inhibition
|
PRKAR2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258762 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687711 |
Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAI1 | down-regulates 
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255008 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23994464 |
The G alpha I subunit inhibits adenylyl cyclase activity and therefore reduces cytoplasmic cAMP levels |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release, Oxytocin signaling |
| + |
3',5'-cyclic AMP | down-regulates activity
chemical inhibition
|
PRKAR2A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258761 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26687711 |
Inactive PKA exists as a holoenzyme, comprised of two regulatory (R) subunits and two catalytic subunits . In the presence of cAMP, the holoenzyme becomes active by binding two cAMP molecules cooperatively to each R subunit, resulting in a conformational change in the R subunits, thus releasing the two C subunits to phosphorylate downstream targets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ENPP1 | down-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253018 |
|
|
|
|
| pmid |
sentence |
| 20923972 |
Phosphodiesterases Catalyze Hydrolysis of cAMP-bound to Regulatory Subunit of Protein Kinase A and Mediate Signal Termination |
|
| Publications: |
1 |
| + |
PDE1A | down-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253398 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22014080 |
PDE1A and PDE1B preferentially hydrolyse cGMP, whereas PDE1C hydrolyses cAMP and cGMP with similar Km values |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP | up-regulates quantity
precursor of
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267842 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11376933 |
To date, ten different mammalian isoforms of adenylyl cyclase (AC) have been cloned and characterized. Each isoform has its own distinct tissue distribution and regulatory properties, providing possibilities for different cells to respond diversely to similar stimuli. The product of the enzymatic reaction catalyzed by ACs, cyclic AMP (cAMP) has been shown to play a crucial role for a variety of fundamental physiological cell functions ranging from cell growth and differentiation, to transcriptional regulation and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
3.0
3',5'-cyclic AMP