| + |
GOT2 | up-regulates quantity 
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267513 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31422819 |
This is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that exists as cytosolic (GOT1) and intramitochondrial (GOT2) isoforms. Both isoforms catalyze the reversible interconversion of oxaloacetate and glutamate into aspartate and α-ketoglutarate. These enzymes are part of the malate-aspartate shuttle (MAS), a key player in intracellular NAD(H) redox homeostasis (Figure 1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266922 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31422819 |
Both isoforms [GOT! AND GOT2] catalyze the reversible interconversion of oxaloacetate and glutamate into aspartate and α-ketoglutarate. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
RIOX1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273475 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
PHF2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273464 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
L-glutamate(1-) | up-regulates quantity
precursor of
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266924 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11863375 |
Alanine aminotransferase (ALT) catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate, and thereby has a key role in the intermediary metabolism of glucose and amino acids. Two ALT isoenzymes are known to exist, but only one ALT gene has been cloned, GPT. In this study, we cloned a homolog of GPT and named it GPT2, and the corresponding protein ALT2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266915 |
|
|
Bos taurus |
|
| pmid |
sentence |
| 11254391 |
Glutamate dehydrogenase is found in all organisms and catalyses the oxidative deamination of l-glutamate to 2-oxoglutarate. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Bos Taurus |
| + |
TMLHE | down-regulates quantity 
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269682 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11431483 |
Epsilon-N-Trimethyllysine hydroxylase (EC ) is the first enzyme in the biosynthetic pathway of l-carnitine and catalyzes the formation of beta-hydroxy-N-epsilon-trimethyllysine from epsilon-N-trimethyllysine, a reaction dependent on alpha-ketoglutarate, Fe(2+), and oxygen. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
alpha-ketoglutarate | up-regulates activity
binding
|
TET2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255706 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25699704 |
A second group of AML patients (15%–33% of all cases) harbor mutations in either the isocitrate dehydrogenase (IDH) 1 or 2 gene (Shih et al., 2012). These enzymes produce α-ketoglutarate (α-KG), which is required for TET activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AML-IDH/TET, AML-IDH/TET, IDH-TET in AML |
| + |
alpha-ketoglutarate | up-regulates 
|
Citric_Acid_Cycle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267821 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15953811 |
A branch-point metabolite α-ketoglutarate is generated in the TCA cycle during the oxidation of carbohydrates and fatty acids and by glutamate dehydrogenase during the oxidative deamination of glutamate. The enzymes that form the mitochondrial α-ketoglutarate– dehydrogenase complex (KGDHC), a key and arguably rate-limiting enzyme system of the tricarboxylic acid cycle, might mediate the interaction of these processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM6B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273461 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
IDH2 | up-regulates quantity
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253134 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29090344 |
Two of the most commonly mutated genes in AML encode for two isoforms of isocitrate dehydrogenase (IDH), IDH1 and IDH2. IDH1 and IDH2 are two isoforms of isocitrate dehydrogenase that perform crucial roles in cellular metabolism. Somatic mutations in either of these two genes impart a neomorphic enzymatic activity upon the encoded enzymes resulting in the ability to convert α-ketoglutarate (αKG) into the oncometabolite R2-hydroxyglutarate (R2-HG), which can competitively inhibit multiple αKG-dependent dioxygenases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261827 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26178471 |
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | AML-IDH/TET, AML-IDH/TET, IDH-TET in AML |
| + |
alpha-ketoglutarate | up-regulates quantity
precursor of
|
(R)-2-hydroxyglutarate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268573 |
|
|
|
|
| pmid |
sentence |
| 25406093 |
Here we show that, in addition to catalyzing oxidation of 3-phosphoglycerate, PHGDH catalyzes NADH-dependent reduction of alpha-ketoglutarate (AKG) to the oncometabolite d-2-hydroxyglutarate (d-2HG). |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
PHF8 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273477 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM4E |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273459 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
UTY |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273460 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM6A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273462 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
HR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273463 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM5B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273476 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
GPT2 | up-regulates quantity
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266925 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11863375 |
Alanine aminotransferase (ALT) catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate, and thereby has a key role in the intermediary metabolism of glucose and amino acids. Two ALT isoenzymes are known to exist, but only one ALT gene has been cloned, GPT. In this study, we cloned a homolog of GPT and named it GPT2, and the corresponding protein ALT2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GOT1 | up-regulates quantity
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267505 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26003525 |
Glutamate oxaloacetate transaminase (GOT) catalyzes the reversible reaction of l-aspartate and α-ketoglutarate into oxaloacetate and L-glutamate and plays a key role in carbon and nitrogen metabolism in all organisms. In human tissues, GOTs are pyridoxal 5'-phosphate-dependent (PLP) enzymes which exist in cytoplasm and mitochondrial forms, GOT1 and GOT2, respectively. GOT1 expression correlates with the growth of several tumors because cancer cells can utilize the amino acid glutamine to fuel anabolic processes, and therefore, GOT1 represents a new therapeutic target in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BBOX1 | down-regulates quantity
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269698 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11802770 |
In the last step, butyrobetaine is hydroxylated on the 3-position by γ-butyrobetaine dioxygenase (BBD; EC 1.14.11.1) to yield carnitine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
oxaloacetate(2-) | up-regulates quantity
precursor of
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267511 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31422819 |
This is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that exists as cytosolic (GOT1) and intramitochondrial (GOT2) isoforms. Both isoforms catalyze the reversible interconversion of oxaloacetate and glutamate into aspartate and α-ketoglutarate. These enzymes are part of the malate-aspartate shuttle (MAS), a key player in intracellular NAD(H) redox homeostasis (Figure 1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267503 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26003525 |
Glutamate oxaloacetate transaminase (GOT) catalyzes the reversible reaction of l-aspartate and α-ketoglutarate into oxaloacetate and L-glutamate and plays a key role in carbon and nitrogen metabolism in all organisms. In human tissues, GOTs are pyridoxal 5'-phosphate-dependent (PLP) enzymes which exist in cytoplasm and mitochondrial forms, GOT1 and GOT2, respectively. GOT1 expression correlates with the growth of several tumors because cancer cells can utilize the amino acid glutamine to fuel anabolic processes, and therefore, GOT1 represents a new therapeutic target in cancer. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
alpha-ketoglutarate | up-regulates quantity
precursor of
|
oxaloacetate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267515 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31422819 |
This is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that exists as cytosolic (GOT1) and intramitochondrial (GOT2) isoforms. Both isoforms catalyze the reversible interconversion of oxaloacetate and glutamate into aspartate and α-ketoglutarate. These enzymes are part of the malate-aspartate shuttle (MAS), a key player in intracellular NAD(H) redox homeostasis (Figure 1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267507 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26003525 |
Glutamate oxaloacetate transaminase (GOT) catalyzes the reversible reaction of l-aspartate and α-ketoglutarate into oxaloacetate and L-glutamate and plays a key role in carbon and nitrogen metabolism in all organisms. In human tissues, GOTs are pyridoxal 5'-phosphate-dependent (PLP) enzymes which exist in cytoplasm and mitochondrial forms, GOT1 and GOT2, respectively. GOT1 expression correlates with the growth of several tumors because cancer cells can utilize the amino acid glutamine to fuel anabolic processes, and therefore, GOT1 represents a new therapeutic target in cancer. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GLUD2 | up-regulates quantity
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268557 |
|
|
Bos taurus |
|
| pmid |
sentence |
| 11254391 |
Glutamate dehydrogenase is found in all organisms and catalyses the oxidative deamination of l-glutamate to 2-oxoglutarate. |
|
| Publications: |
1 |
Organism: |
Bos Taurus |
| + |
IDH | up-regulates quantity
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266252 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28139779 |
Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
alpha-ketoglutarate | up-regulates quantity
precursor of
|
succinate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269686 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11431483 |
Epsilon-N-Trimethyllysine hydroxylase (EC ) is the first enzyme in the biosynthetic pathway of l-carnitine and catalyzes the formation of beta-hydroxy-N-epsilon-trimethyllysine from epsilon-N-trimethyllysine, a reaction dependent on alpha-ketoglutarate, Fe(2+), and oxygen. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
D2HGDH | up-regulates quantity
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253131 |
|
|
|
|
| pmid |
sentence |
| 26178471 |
Here we show that wild-type D2HGDH elevates α-KG levels |
|
| Publications: |
1 |
| + |
D-threo-isocitrate(3-) | up-regulates quantity
precursor of
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266250 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28139779 |
Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM4A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273465 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273472 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM5D |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273473 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM4C |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273474 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
GLUD1 | up-regulates quantity
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266916 |
|
|
Bos taurus |
|
| pmid |
sentence |
| 11254391 |
Glutamate dehydrogenase is found in all organisms and catalyses the oxidative deamination of l-glutamate to 2-oxoglutarate. |
|
| Publications: |
1 |
Organism: |
Bos Taurus |
| + |
GOT1 | down-regulates quantity
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268062 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26003525 |
Glutamate oxaloacetate transaminase (GOT) catalyzes the reversible reaction of l-aspartate and α-ketoglutarate into oxaloacetate and L-glutamate and plays a key role in carbon and nitrogen metabolism in all organisms. In human tissues, GOTs are pyridoxal 5'-phosphate-dependent (PLP) enzymes which exist in cytoplasm and mitochondrial forms, GOT1 and GOT2, respectively. GOT1 expression correlates with the growth of several tumors because cancer cells can utilize the amino acid glutamine to fuel anabolic processes, and therefore, GOT1 represents a new therapeutic target in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
HIF1A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253138 |
|
|
|
|
| pmid |
sentence |
| 20383689 |
HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression|The hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are enzymes that are functionally inactivated in hypoxia, as they use both oxygen and alpha-ketoglutarate as substrates to hydroxylate target prolyl residues. |
|
| Publications: |
1 |
| + |
IDH1 | up-regulates quantity
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253135 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29090344 |
Two of the most commonly mutated genes in AML encode for two isoforms of isocitrate dehydrogenase (IDH), IDH1 and IDH2. IDH1 and IDH2 are two isoforms of isocitrate dehydrogenase that perform crucial roles in cellular metabolism. Somatic mutations in either of these two genes impart a neomorphic enzymatic activity upon the encoded enzymes resulting in the ability to convert α-ketoglutarate (αKG) into the oncometabolite R2-hydroxyglutarate (R2-HG), which can competitively inhibit multiple αKG-dependent dioxygenases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261828 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26178471 |
Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | AML-IDH/TET, AML-IDH/TET, IDH-TET in AML |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM2A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273478 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM3A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273479 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM4F |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273480 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
OGDC | down-regulates quantity
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266257 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15953811 |
The α-ketoglutarate–dehydrogenase complex is a complex including multiple copies of three proteins: E1k (α-ketoglutarate dehydrogenase), E2k (dihydrolipoyl succinyltransferase), and E3 (dihydrolipoamide dehydrogenase) (Fig. 2). The consecutive action of the three catalytic components of KGDHC results in oxidative decarboxylation of 2-oxoglutarate, preserving the energy in the form of succinylCoA and NADH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
alpha-ketoglutarate | up-regulates quantity
precursor of
|
succinyl-CoA(5-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266253 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15953811 |
The α-ketoglutarate–dehydrogenase complex is a complex including multiple copies of three proteins: E1k (α-ketoglutarate dehydrogenase), E2k (dihydrolipoyl succinyltransferase), and E3 (dihydrolipoamide dehydrogenase) (Fig. 2). The consecutive action of the three catalytic components of KGDHC results in oxidative decarboxylation of 2-oxoglutarate, preserving the energy in the form of succinylCoA and NADH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM4B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273466 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM5A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273467 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM5C |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273468 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM4D |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273469 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM7A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273470 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
alpha-ketoglutarate | up-regulates activity
chemical activation
|
KDM3B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273471 |
|
|
|
|
| pmid |
sentence |
| 29981745 |
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3. |
|
| Publications: |
1 |
| + |
GOT2 | down-regulates quantity
chemical modification
|
alpha-ketoglutarate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268058 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31422819 |
This is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that exists as cytosolic (GOT1) and intramitochondrial (GOT2) isoforms. Both isoforms catalyze the reversible interconversion of oxaloacetate and glutamate into aspartate and α-ketoglutarate. These enzymes are part of the malate-aspartate shuttle (MAS), a key player in intracellular NAD(H) redox homeostasis (Figure 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
alpha-ketoglutarate
