Summary

Name NOTCH1
Full Name Neurogenic locus notch homolog protein 1
Synonyms Notch 1, hN1, Translocation-associated notch protein TAN-1 | TAN1
Primary ID P46531
Links - -
Type protein
Relations 108
Pathways NOTCH Signaling, NOTCH Signaling and Myogenesis, FAP: Notch
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png hydroxylation NOTCH1 0.16
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deubiquitination NOTCH1 0.20
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png acetylation NOTCH1 0.24
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOTCH1
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization NOTCH1 0.16
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination NOTCH1 0.29
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization NOTCH1 0.19
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.39
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling
+ up-regulates img/direct-activation.png ubiquitination NOTCH1 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.47
Publications: 3 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates activity img/direct-activation.png cleavage NOTCH1 0.21
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding NOTCH1 0.09
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding NOTCH1
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH1
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1 0.54
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage NOTCH1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination NOTCH1
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown BMPR1A/1B/2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation NOTCH1
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LFNG
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ up-regulates img/direct-activation.png binding NOTCH1 0.25
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding SNW1 0.25
Publications: 2 Organism: Bacteriovorax Stolpii, Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKB1 0.18
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ down-regulates img/direct_inhibition.png deacetylation NOTCH1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization HIF1A
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.12
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding RBPJ/NOTCH
Publications: 1
Pathways:FAP: Notch, NOTCH Signaling, NOTCH Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.07
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RBPJ 0.79
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding NOTCH1 0.07
Publications: 1 Organism: Mus Musculus
Tissue: MEF Cell
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.06
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HEYL 0.07
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates img/direct-activation.png binding NOTCH1 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TCFL5 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ADAM19 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL11B 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.25
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png glycosylation NOTCH1 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HEY1 0.17
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.83
Publications: 1 Organism: Drosophila Melanogaster
Pathways:NOTCH Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.71
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: Notch, NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PIN1 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.65
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: Notch, NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.11
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKB2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.15
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding TCF3 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ERBB2 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FABP7 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination NOTCH1 0.29
Publications: 3 Organism: Drosophila Melanogaster, Homo Sapiens, Mus Musculus
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates img/direct-activation.png relocalization NOTCH1 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png glycosylation, binding NOTCH1 0.11
Publications: 2 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png binding NOTCH1 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.18
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.04
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png glycosylation NOTCH1 0.04
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.04
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
Pathways:FAP: Notch
+ up-regulates img/direct-activation.png binding NOTCH1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png unknown PAX7 0.07
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle, Satellite Cell
Pathways:NOTCH Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYC 0.16
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates img/indirect-activation.png unknown Differentiation
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH1 0.08
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination NOTCH1 0.40
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling and Myogenesis
+ up-regulates img/direct-activation.png relocalization NOTCH1 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization NOTCH1 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL7R 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TCF12 0.19
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.03
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding NOTCH1 0.54
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOTCH1 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.18
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HOXA5 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD44 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL2RA
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: Notch, NOTCH Signaling, NOTCH Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown NOTCH1
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates activity img/direct-activation.png cleavage NOTCH1
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: Notch, NOTCH Signaling, NOTCH Signaling and Myogenesis