| + |
MAPK8 | down-regulates activity 
phosphorylation
|
PPARG |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46518 |
Ser112 |
AIKVEPAsPPYYSEK |
Homo sapiens |
|
| pmid |
sentence |
| 9030579 |
The a/b domain of human ppargamma1 was phosphorylated in vivo, and this was abolished either by mutation of serine 84 to alanine (s84a) or coexpression of a phosphoprotein phosphatase. In vitro, this domain was phosphorylated by erk2 and jnk, and this was markedly reduced in the s84a mutant. Thus, phosphorylation of a mitogen-activated protein kinase site in the a/b region of ppargamma inhibits both ligand-independent and ligand-dependent transactivation functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
MAPK1 | down-regulates quantity by destabilization
phosphorylation
|
PPARG |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112544 |
Ser112 |
AIKVEPAsPPYYSEK |
Homo sapiens |
|
| pmid |
sentence |
| 11733495 |
Moreover, the inhibition of erks 1 and 2 with a mek inhibitor, u1026, lead to an inhibition in the decay of ppargamma proteins, indicating that serine phosphorylation influences the degradation of ppargamma in fat cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates quantity by destabilization
phosphorylation
|
PPARG |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179404 |
Ser112 |
AIKVEPAsPPYYSEK |
Homo sapiens |
|
| pmid |
sentence |
| 11733495 |
Moreover, the inhibition of erks 1 and 2 with a mek inhibitor, u1026, lead to an inhibition in the decay of ppargamma proteins, indicating that serine phosphorylation influences the degradation of ppargamma in fat cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates activity 
phosphorylation
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232236 |
Ser112 |
AIKVEPAsPPYYSEK |
Homo sapiens |
|
| pmid |
sentence |
| 11733495 |
Moreover, the inhibition of erks 1 and 2 with a mek inhibitor, u1026, lead to an inhibition in the decay of ppargamma proteins, indicating that serine phosphorylation influences the degradation of ppargamma in fat cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, Leptin Signaling, MTOR Signaling, Rett syndrome, Thyroid cancer |
| + |
ABL1 | up-regulates quantity
phosphorylation
|
PPARG |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262297 |
Tyr102 |
YDLKLQEyQSAIKVE |
Mus musculus |
HEK-293 Cell, 3T3-L1 Cell |
| pmid |
sentence |
| 25368164 |
We show that the tyrosine kinase Abelson murine leukemia viral oncogene (cAbl) is an adipogenic key regulator. c-Abl promotes adipogenesis by phosphorylation and subsequent stabilization of PPARγ. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255912 |
Tyr78 |
SSISTPHyEDIPFTR |
Mus musculus |
|
| pmid |
sentence |
| 25368164 |
We show that the tyrosine kinase Abelson murine leukemia viral oncogene (cAbl) is an adipogenic key regulator. c-Abl promotes adipogenesis by phosphorylation and subsequent stabilization of PPARγ. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
SOX6 | up-regulates quantity by expression 
transcriptional regulation
|
PPARG |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255822 |
|
|
Homo sapiens |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 26893351 |
We found that SOX6 regulates adipogenesis in vertebrate species by activating adipogenic regulators including PPARγ, C/EBPα and MEST |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF5 | up-regulates
transcriptional regulation
|
PPARG |
0.604 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210010 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16054042 |
Klf5 expression is induced by c/ebpbeta and delta. KLF5, in turn, acts in concert with c/ebpbeta/delta to activate the ppargamma2 promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
PPARG | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256229 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16150867 |
Adipocyte differentiation is regulated largely through the actions of the peroxisome proliferator-activated receptor (PPAR) gamma nuclear receptor |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228622 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16150867 |
Adipocyte differentiation is regulated largely through the actions of the peroxisome proliferator-activated receptor (PPAR) gamma nuclear receptor |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Tissue: |
Mammary Epithelial Cell |
| Pathways: | Adipogenesis, Circadian clock, FAP: Insulin-mediated adipogenesis, Leptin Signaling, MTOR Signaling, PPARgamma in cancer |
| + |
perfluorooctane-1-sulfonic acid | up-regulates activity
chemical activation
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268787 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 16731579 |
Taken together, these data show that of the NRs studied, PPARα is the most likely target of PFOA and PFOS, although PPARγ is also activated to some extent. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD1/4 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236233 |
|
|
Homo sapiens |
C3H10T1/2 Cell |
| pmid |
sentence |
| 12589053 |
Overexpression of Smad6, a natural antagonist for Smad1, blocked PPARgamma expression and adipocytic differentiation induced by BMP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18854943 |
This Smad1/4 complex can directly interact with Shn-2 and C/EBP a on the PPAR g promoter thus, resulting in the transcriptional activation of PPAR g |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Noncanonical PRC1 | down-regulates quantity by repression 
transcriptional regulation
|
PPARG |
0.324 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252251 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25533466 |
We concluded that FBXL10 recruits the noncanonical PRC1 complex to directly repress Cdk1, Uhrf1, and Pparg that may account for the FBXL10-mediated inhibition of adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPB | up-regulates quantity
transcriptional regulation
|
PPARG |
0.72 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143952 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16431920 |
These data suggest that c/CEBP beta activates a single unified pathway of adipogenesis involving its stimulation of PPARgamma expression, which then activates C/EBP alpha expression by dislodging HDAC1 from the promoter for degradation in the proteasome |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255730 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 7557387 |
Induction of C/EBP beta DNA-binding activity in NIH-3T3 beta 2 cells exposed to dexamethasone in the presence of insulin and fetal bovine serum activates the expression of an adipocyte-specific nuclear hormone receptor, PPAR gamma, that stimulates the conversion of these fibroblasts into committed preadipocytes |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
PPARG | up-regulates
|
M2_polarization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249542 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17681149 |
This mechanism is mainly operative in native monocytes that, in the presence of an appropriate M2 stimulus such as IL-4, can be primed by PPARg ligands to an enhanced M2 phenotype. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
CPT1B |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254581 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 15356291 |
Mutation analysis indicated that the MEF2 site contributed to the activation of the CPT1beta promoter by PPAR in C2C12 cells. The reporter construct containing the PPRE and the MEF2C site was synergistically activated by co-expression of PPAR, retinoid X receptor (RXR) and MEF2C in non-muscle cells. Moreover, protein-binding assays demonstrated that MEF2C and PPAR specifically bound to one another in vitro. Also for the synergistic activation of the CPT1beta gene promoter by MEF2C and PPARalpha-RXRalpha, a precise arrangement of its binding sites was essential. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GLI2 | down-regulates
|
PPARG |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256224 |
|
|
|
|
| pmid |
sentence |
| 29205155 |
Molecularly, Gli2 is the principle transcription factor in the Gli family to mediate the anti-adipogenic and anti-lipogenic effects of Hh signaling |
|
| Publications: |
1 |
| Tissue: |
Mammary Epithelial Cell |
| + |
NOTCH1 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90455 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12107827 |
Addition of jag-1 peptide induced ikkalpha mediated nf-kappab activation, as well as increased ppargamma expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | Rett syndrome |
| + |
MEK1/2 | up-regulates
binding
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244971 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18596912 |
The genomic activity of ppargamma is modulated, in addition to ligand binding, by phosphorylation of a serine residue by mapks, such as extracellular signal-regulated protein kinases-1/2 (erk-1/2), or by nucleocytoplasmic compartmentalization through the erk activators mapk kinases-1/2 (mek-1/2). These mapks phosphorylate (in humans) ser 84 in the ppargamma1 and ser 114 in ppargamma2 isoform. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, Rett syndrome, Thyroid cancer |
| + |
PPARG | up-regulates
transcriptional regulation
|
FABP4 |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210149 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 8943212 |
We report that insulin and a ppargamma ligand (thiazolidinedione (tzd)) stimulate in a synergistic manner the expression of an adipocyte-specific gene (ap2) in rat adipocytes and 3t3-l1 cells |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
SREBF1 | up-regulates activity
|
PPARG |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170607 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9539737 |
Finally, we demonstrate directly that cells expressing ADD1/SREBP1 produce and secrete lipid molecule(s) that bind directly to PPARgamma, displacing the binding of radioactive thiazolidinedione ligands |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock, MTOR Signaling |
| + |
15(S)-HETE | up-regulates activity
chemical activation
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254095 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12517954 |
15(S)-HETE is a ligand for PPARγ in IL-4-stimulated A549 cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF2 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95519 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12426306 |
Constitutive overexpression of klf2 but not klf15 potently inhibits peroxisome proliferator-activated receptor-gamma (ppargamma) expression with no effect on the upstream regulators c/ebpbeta and c/ebpdelta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ASXL2 | up-regulates activity
binding
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260063 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21047783 |
ASXL2, which does not bind HP1, promotes differentiation by binding to PPARγ and increasing the level of methylated H3K4, leading to the elevation of PPARγ activity. Our genome-wide analysis confirmed the physiological roles of ASXL1 and ASXL2 in adipogenesis at the molecular level, supporting the hypothesis that ASXL1 is an authentic corepressor of PPARγ, whereas ASXL2 is a PPARγ coactivator, and that together ASXL1 and ASXL2 fine-tune adipogenesis via differential regulation of PPARγ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA2 | down-regulates activity
|
PPARG |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132949 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20510530 |
GATA2 interacts directly with PPARG and C/EBP a , which may deplete PPARG involved in the promotion of adipogenesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis |
| + |
NR3C1 | up-regulates quantity
transcriptional regulation
|
PPARG |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255963 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 8754811 |
Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids. The dose of DEX required to promote maximal expression of PPARg mRNA is approximately 10 nM, which is within the range of the Kd for the association of DEX with the glucocorticoid receptor in 3T3-L1 cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, Circadian clock |
| + |
RXRB | up-regulates
binding
|
PPARG |
0.645 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78907 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10882139 |
The nuclear receptor ppargamma/rxralpha heterodimer regulates glucose and lipid homeostasis |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
CXCR2 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271682 |
|
|
|
|
| pmid |
sentence |
| 18292390 |
EMSA, ChIP, and transient transfection assays indicate that PPAR-gamma activates the CXCR2 promoter by binding to a PPAR response element (PPRE). |
|
| Publications: |
1 |
| + |
KLF2 | down-regulates
transcriptional regulation
|
PPARG |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210019 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12426306 |
Constitutive overexpression of klf2 but not klf15 potently inhibits peroxisome proliferator-activated receptor-gamma (ppargamma) expression with no effect on the upstream regulators c/ebpbeta and c/ebpdelta. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | down-regulates quantity by repression
transcriptional regulation
|
CTNNB1 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164516 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20303941 |
The results from mammalian one-hybrid experiments showed that functional ppar gamma was necessary for ligand-dependent inhibition of beta-catenin transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | PPARgamma in cancer, Thyroid cancer |
| + |
rosiglitazone | up-regulates activity
chemical activation
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251646 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 7768881 |
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma) |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
RXR | up-regulates activity
binding
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259057 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | PPARgamma in cancer |
| + |
RXRA | up-regulates
binding
|
PPARG |
0.724 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11237216 |
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | down-regulates activity
|
PPARG |
0.534 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254682 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24948596 |
IL-4 was shown to inhibit lipid accumulation in adipose tissue by a mechanism that includes activation of Stat6, which suppresses PPARα transcriptional activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Macrophage polarization |
| + |
E2F1 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90459 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12110166 |
We show here that e2f1 induces ppar gamma transcription during clonal expansion, whereas e2f4 represses pparg amma expression during terminal adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SETDB1/NLK/CHD7 | down-regulates activity
transcriptional regulation
|
PPARG |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253524 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21952300 |
The non-canonical WNT ligand WNT5A activates the histone methyltransferase SET domain bifurcated 1 (SETDB1). SETDB1 forms a complex with chromodomain helicase DNA-binding 7 (CHD7) and NEMO-like kinase (NLK) to inhibit the ability of PPARγ to transcriptionally activate its downstream metabolic target genes in the MSC cell line ST2 and in 3T3-L1 cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252910 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 16670091 |
FOXO1 coexpression dose-dependently repressed transcription from either the PPARgamma 1 or PPARgamma2 promoter reporter by 65%, whereas insulin (100 nm, 20-24 h) either partially or completely reversed this effect. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
CREBL2 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261573 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 21728997 |
Accordingly, the results of QPCR and immunoblot analysis showed that during adipogenesis, both the mRNA (Figures 4D and 4E) and protein (Figure 4F) levels of PPARγ , as well as C/EBPα, in 3T3-L1 preadipocytes transfected with either siCREBL2-1 or siCREBL2-2 were significantly decreased compared with the control (P < 0.05), suggesting that knockdown of CREBL2 protein suppress 3T3-L1 preadipocyte differentiation via inhibition of PPARγ and C/EBPα expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Monobutylphthalate | up-regulates activity
chemical activation
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268752 |
|
|
Homo sapiens |
Breast Cell Line |
| pmid |
sentence |
| 16326050 |
Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | down-regulates
|
STAT3 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249556 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 17681149 |
Transcriptional repression of inflammatory response genes occurs by negative interference of PPARg with the nuclear factor kB (NF-kB), signal transducer and activator of transcription (STAT), and activating protein 1 (AP-1) signaling pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling, Macrophage polarization |
| + |
MAPK1 | down-regulates
relocalization, phosphorylation
|
PPARG |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179400 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18596912 |
The genomic activity of ppargamma is modulated, in addition to ligand binding, by phosphorylation of a serine residue by mapks, such as extracellular signal-regulated protein kinases-1/2 (erk-1/2), or by nucleocytoplasmic compartmentalization through the erk activators mapk kinases-1/2 (mek-1/2). These mapks phosphorylate (in humans) ser 84 in the ppargamma1 and ser 114 in ppargamma2 isoform |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210182 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18596912 |
The genomic activity of ppargamma is modulated, in addition to ligand binding, by phosphorylation of a serine residue by mapks, such as extracellular signal-regulated protein kinases-1/2 (erk-1/2), or by nucleocytoplasmic compartmentalization through the erk activators mapk kinases-1/2 (mek-1/2). These mapks phosphorylate (in humans) ser 84 in the ppargamma1 and ser 114 in ppargamma2 isoform |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FGFR2 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236220 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17543283 |
Furthermore, in cultures receiving FGF-2 before adipogenic induction, mRNA expression of peroxisome proliferator-activated receptor gamma (PPARgamma), a key transcription factor in adipogenesis, was upregulated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254743 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 14614508 |
Overexpression of HES-1 fully repressed PPAR-g even in the presence of the ACREB inhibitor, showing that HES-1 acts downstream of CREB |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
UCP1 |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263985 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 32991581 |
NFIA binds to and activates the brown-fat-specific enhancers even before differentiation and later facilitates the binding of PPARgamma|NFIA has at least three functions on the transcriptional regulation of brown fat [2]. First, NFIA activates adipogenesis per se, through activating the transcription of Pparg, which encodes PPARgamma. Second, NFIA also activates the brown-fat-specific gene expression (such as Ucp1 and Ppargc1a) independent of the degree of adipocyte differentiation, through facilitating the binding of PPARgamma to the brown-fat-specific enhancers. Third, NFIA represses myogenesis through suppression of myogenic transcription factors such as Myod1 as well as Myog, |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARG | down-regulates
relocalization
|
HDAC1 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143961 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16431920 |
These data suggest that c/ebp beta activates a single unified pathway of adipogenesis involving its stimulation of ppargamma expression, which then activates c/ebp alpha expression by dislodging hdac1 from the promoter for degradation in the proteasome |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Prostate Cancer |
| + |
perfluorooctanoic acid | up-regulates activity
chemical activation
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268788 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 16731579 |
Taken together, these data show that of the NRs studied, PPARα is the most likely target of PFOA and PFOS, although PPARγ is also activated to some extent. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
dexamethasone | up-regulates
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106475 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
|
PPARG |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210090 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12589053 |
Specific inhibitors for p38 kinase inhibited bmp2-induced adipocytic differentiation and transcriptional activation of ppargamma, whereas overexpression of smad6 had no effect on transcriptional activity of ppargamma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21633182 |
Interestingly, SIRT1 suppresses PPARγ but activates PGC-1α , and thus affects the clock network through multiple mechanisms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
monoisononyl phthalate | up-regulates activity
chemical activation
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268782 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 27551952 |
MEHP and MiNP exhibit potent activation of hCAR2 and hPXR with higher affinities for these receptors than for the hPPARs. The rank order potency for MEHP and MiNP was hCAR2 > hPXR > hPPARs. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
FZD1 | down-regulates
|
PPARG |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80598 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | down-regulates quantity by repression
|
NfKb-p65/p50 |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249555 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 17681149 |
Transcriptional repression of inflammatory response genes occurs by negative interference of PPARg with the nuclear factor kB (NF-kB), signal transducer and activator of transcription (STAT), and activating protein 1 (AP-1) signaling pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
CEBPD | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253062 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 10649448 |
We conclude that glucocorticoid-induced adipogenesis from bone marrow stromal cells is mediated through a reaction cascade in which dexamethasone transcriptionally activates C/EBPdelta; C/EBPdelta then binds to PPARgamma2 promoter and transactivates PPARgamma2 gene expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
Fatty acid | up-regulates
|
PPARG |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256189 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29369787 |
Omega 3 fatty acids and fibrates are considered as natural and pharmacological ligands of PPARα, respectively, that reduce inflammation and arteriosclerosis in cardiovascular system |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | PPARgamma in cancer |
| + |
GATA3 | down-regulates
transcriptional regulation
|
PPARG |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210025 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15632071 |
Constitutive expression of both gata-2 and gata-3 suppressed adipocyte differentiation, partially through direct binding to the peroxisome proliferator-activated receptor gamma (ppargamma) promoter and suppression of its basal activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.898 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263984 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 32991581 |
NFIA binds to and activates the brown-fat-specific enhancers even before differentiation and later facilitates the binding of PPARgamma|NFIA has at least three functions on the transcriptional regulation of brown fat [2]. First, NFIA activates adipogenesis per se, through activating the transcription of Pparg, which encodes PPARgamma. Second, NFIA also activates the brown-fat-specific gene expression (such as Ucp1 and Ppargc1a) independent of the degree of adipocyte differentiation, through facilitating the binding of PPARgamma to the brown-fat-specific enhancers. Third, NFIA represses myogenesis through suppression of myogenic transcription factors such as Myod1 as well as Myog, |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock, MTOR Signaling |
| + |
miR-27b | down-regulates quantity
post transcriptional regulation
|
PPARG |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264608 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 26239616 |
Overexpression of miR-132 significantly reduced the expression levels of MeCP2, at both the mRNA and protein level, whereas downregulation of miR-132 increased the mRNA and protein expression levels of MeCP2 |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Rett syndrome |
| + |
E2F4 | down-regulates
transcriptional regulation
|
PPARG |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210050 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12110166 |
we show here that e2f1 induces ppar gamma transcription during clonal expansion, whereas e2f4 represses pparg amma expression during terminal adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253584 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14614508 |
CREB inhibits hepatic PPAR-gamma expression in the fasted state by stimulating the expression of the Hairy Enhancer of Split (HES-1) gene, a transcriptional repressor that is shown here to be a mediator of fasting lipid metabolism in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
3-isobutyl-1-methyl-7H-xanthine | up-regulates
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates activity
relocalization
|
PPARG |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179407 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18596912 |
The genomic activity of ppargamma is modulated, in addition to ligand binding, by phosphorylation of a serine residue by mapks, such as extracellular signal-regulated protein kinases-1/2 (erk-1/2), or by nucleocytoplasmic compartmentalization through the erk activators mapk kinases-1/2 (mek-1/2). These mapks phosphorylate (in humans) ser 84 in the ppargamma1 and ser 114 in ppargamma2 isoform |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD3/SMAD4 | down-regulates activity
|
PPARG |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17139329 |
Phosphorylation of receptor-regulated SMADs (for example, SMAD1 or SMAD3) stimulates dimer formation with SMAD4 and translocation to the nucleus, where the SMADs regulate the transcription of target gene SMAD3 binds to C/EBPs and inhibits their transcriptional activity, including their ability to transactivate the Pparg2 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235619 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis, Leptin Signaling, MTOR Signaling |
| + |
ERK1/2 | up-regulates quantity by expression
phosphorylation
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235334 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 12270934 |
Our results suggest that activation of the MEK/ERK signaling pathway during the initial 12 h of adipogenesis enhances the activity of factors that regulate both C/EBPalpha and PPARgamma expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, Leptin Signaling, MTOR Signaling, Rett syndrome, Thyroid cancer |
| + |
NCOR2 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.733 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253508 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22395773 |
In differentiated adipocyte cell lines, SIRT1 inhibits adipogenesis and enhances fat mobilization through lipolysis by suppressing the activity of PPARγ. SIRT1 achieves this by promoting the assembly of a corepressor complex, involving NCoR1 and SMRT, on the promoters of PPARγ target genes to repress their transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA4 | up-regulates
binding
|
PPARG |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67687 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10347167 |
Identification of ara70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. / ppargamma and ara70 interact in the absence of the ppargamma ligand 15-deoxy-delta12,14-prostaglandin j2, although the addition of exogenous ligand enhances this interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD5 | down-regulates
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80610 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10937998 |
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | down-regulates quantity by repression
transcriptional regulation
|
GLS |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268043 |
|
|
Homo sapiens |
Naive T-lymphocyte |
| pmid |
sentence |
| 33754076 |
Furthermore, the protein level of the rate-limiting enzyme GLS1 but not GLUD1, GOT1, or GPT2 was consistently reduced by PPARγ agonists |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.567 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-218013 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 16670091 |
FOXO1 coexpression dose-dependently repressed transcription from either the PPARgamma 1 or PPARgamma2 promoter reporter by 65%, whereas insulin (100 nm, 20-24 h) either partially or completely reversed this effect. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis, Leptin Signaling |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
ARNTL |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268026 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19041764 |
Rosiglitazone treatment induced aortic expression of Bmal1 mRNA, and ChIP and promoter assays revealed that Bmal1 is a direct PPARgamma target gene. These studies have uncovered a role for vascular PPARgamma as a peripheral factor participating in regulation of cardiovascular rhythms. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock |
| + |
miR-27a | down-regulates quantity
post transcriptional regulation
|
PPARG |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265770 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 26344767 |
We also found that miR-199a expression and blockade (see below for details) potentiated and attenuated, respectively, the phosphorylation levels in neurons of S6 ribosomal protein, which signify the activation of mTOR signaling, indicating that miR-199a positively regulates mTOR signaling activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Rett syndrome |
| + |
mono(2-ethylhexyl) phthalate | up-regulates activity
chemical activation
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268751 |
|
|
in vitro |
|
| pmid |
sentence |
| 16326050 |
Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268747 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19433246 |
Phthalates are true ligands of PPARs. Mono-ethyl-hexyl-phthalate (MEHP), a metabolite of the widespread plasticizer di-ethyl-hexyl-phthalate (DEHP), has been found in exposed organisms and interacts with all three PPARs. A thorough analysis of its interactions with PPARgamma identified MEHP as a selective PPARgamma modulator, and thus a possible contributor to the obesity epidemic. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268785 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 27551952 |
MEHP and MiNP exhibit potent activation of hCAR2 and hPXR with higher affinities for these receptors than for the hPPARs. The rank order potency for MEHP and MiNP was hCAR2 > hPXR > hPPARs. |
|
| Publications: |
3 |
Organism: |
In Vitro, Homo Sapiens, Chlorocebus Aethiops |
| + |
KDM2B | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252246 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25533466 |
We concluded that FBXL10 recruits the noncanonical PRC1 complex to directly repress Cdk1, Uhrf1, and Pparg that may account for the FBXL10-mediated inhibition of adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IL15RA | down-regulates activity
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256228 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
In addition, level of mRNAs encoding C/EBPa, PPARg and FABP4, the classic adipogenic markers, was significantly lower in samples administrated with IL-15 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250561 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 11279134 |
The differentiation of 3T3-L1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the CCAAT/enhancer-binding proteins (C/EBPs) and peroxisome proliferator-activated receptor gamma (PPARgamma) by dexamethasone (DEX), 3-isobutyl-1-methylxanthine (MIX), and insulin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255753 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 10649448 |
The dose of DEX required to promote maximal expression of PPARg mRNA is approximately 10 nM, which is within the range of the Kd for the association of DEX with the glucocorticoid receptor in 3T3-L1 cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256120 |
|
|
Mus musculus |
Preadipocyte Cell Line |
| pmid |
sentence |
| 27777311 |
We observed GR binding on or near Cebpβ, Cebpδ, Klf5, Klf9, Cebpα, and Pparγ gene loci at 4 h but not at 0 h of adipogenesis. Thus, at least one of the mechanisms by which GR promotes adipogenesis in culture is by directly activating the expression of multiple adipogenic TFs. |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, Circadian clock |
| + |
PPARG | up-regulates activity
|
JUN |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249558 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 17681149 |
Transcriptional repression of inflammatory response genes occurs by negative interference of PPARg with the nuclear factor kB (NF-kB), signal transducer and activator of transcription (STAT), and activating protein 1 (AP-1) signaling pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGR1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.605 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263508 |
|
|
Homo sapiens |
Pulmonary Artery Smooth Muscle Cell |
| pmid |
sentence |
| 29212876 |
Previous studies have reported that the PPARγ proximal promoter contains an overlapping binding site for Egr-1, which is involved in the down-regulation of PPARγ. In the present study, we have provided direct evidence that leptin causes PPARγ reduction in primary cultured PASMC; this effect is coupled to leptin-induced ERK1/2 activation and subsequent induction of Egr-1, which further down-regulates PPARγ expression and results in PASMC proliferation. The present study confirmed that ERK1/2 signaling cascade mediated leptin-induced PPARγ reduction by up-regulation of Egr-1 in PASMC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
MAP2K2 | up-regulates
binding
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179393 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18596912 |
The genomic activity of ppargamma is modulated, in addition to ligand binding, by phosphorylation of a serine residue by mapks, such as extracellular signal-regulated protein kinases-1/2 (erk-1/2), or by nucleocytoplasmic compartmentalization through the erk activators mapk kinases-1/2 (mek-1/2). These mapks phosphorylate (in humans) ser 84 in the ppargamma1 and ser 114 in ppargamma2 isoform. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWTR1 | down-regulates
binding
|
PPARG |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22153608 |
Kmp also enhanced the association of taz with ppar_, thereby suppressing the gene transcription of ppar_ targets and resulting in diminished adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ASXL1 | down-regulates activity
binding
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260064 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21047783 |
Our genome-wide analysis confirmed the physiological roles of ASXL1 and ASXL2 in adipogenesis at the molecular level, supporting the hypothesis that ASXL1 is an authentic corepressor of PPARγ, whereas ASXL2 is a PPARγ coactivator, and that together ASXL1 and ASXL2 fine-tune adipogenesis via differential regulation of PPARγ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD2 | down-regulates
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80604 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
FABP4 |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45294 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8943212 |
We report that insulin and a ppargamma ligand (thiazolidinedione (tzd)) stimulate in a synergistic manner the expression of an adipocyte-specific gene (ap2) in rat adipocytes and 3t3-l1 cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
E2F1 | up-regulates
transcriptional regulation
|
PPARG |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210047 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12110166 |
We show here that e2f1 induces ppar gamma transcription during clonal expansion, whereas e2f4 represses pparg amma expression during terminal adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | up-regulates activity
transcriptional regulation
|
CEBPA |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235358 |
|
|
Mus musculus |
MEF Cell, 3T3-L1 Cell, Swiss-3T3 Cell |
| pmid |
sentence |
| 16431920 |
These data suggest that c/ebp beta activates a single unified pathway of adipogenesis involving its stimulation of ppargamma expression, which then activates c/ebp alpha expression by dislodging hdac1 from the promoter for degradation in the proteasome |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
BMP7 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180311 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16;ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha;ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
WNT5B | up-regulates
|
PPARG |
0.257 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186625 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19577541 |
Wnt5b additionally appears to be a potent enhancer of adipogenic capacity by stimulation of ppargamma |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD1 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236227 |
|
|
Mus musculus |
C3H10T1/2 Cell |
| pmid |
sentence |
| 12589053 |
Overexpression of smad6, a natural antagonist for smad1, blocked ppargamma expression and adipocytic differentiation induced by bmp2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GATA2 | down-regulates quantity
transcriptional regulation
|
PPARG |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259949 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19772889 |
These findings indicate that fatty marrow replacement in AA patients can be explained by downregulation of GATA-2 and overexpression of PPARgamma in MSCs. Decreased expression of GATA-2 might be responsible for the pathogenesis and development of the clinical features of the disease. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, FAP: Insulin-mediated adipogenesis |
| + |
PPARG | down-regulates activity
binding
|
ACADM |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261264 |
|
|
Homo sapiens |
THP-1 Cell |
| pmid |
sentence |
| 28974683 |
This truncated PPARγ translocates to mitochondria, where it directly interacts with medium-chain acyl-CoA dehydrogenase (MCAD). This binding event attenuates MCAD activity and inhibits fatty acid oxidation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOR1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.693 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253507 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22395773 |
In differentiated adipocyte cell lines, SIRT1 inhibits adipogenesis and enhances fat mobilization through lipolysis by suppressing the activity of PPARγ. SIRT1 achieves this by promoting the assembly of a corepressor complex, involving NCoR1 and SMRT, on the promoters of PPARγ target genes to repress their transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3-isobutyl-1-methylxanthine | up-regulates
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106484 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
E2F4 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90507 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12110166 |
We show here that e2f1 induces ppar gamma transcription during clonal expansion, whereas e2f4 represses pparg amma expression during terminal adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | down-regulates activity
binding
|
PPARG |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256072 |
|
|
Mus musculus |
Corneal Fibroblast Cell Line |
| pmid |
sentence |
| 16847334 |
Oncogenic beta-catenin resists proteasomal degradation by inhibiting PPARgamma activity, which requires its TCF/LEF binding domain |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | PPARgamma in cancer, Thyroid cancer |
| + |
PPARG | down-regulates activity
|
PTEN |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251997 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23128507 |
The PAX8-PPARγ rearrangement leads to strong induction of the PPARγ protein and the consequent abrogation of the normal PPARγ function. PPARγ overexpression abolishes the PTEN-inhibitory effect on immunoactive AKT, which in turn induces the PI3K signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | MTOR Signaling, Prostate Cancer, Thyroid cancer |
| + |
CTNNB1 | down-regulates
|
PPARG |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80592 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10937998 |
Wnt-10b, is a molecular switch that governs adipogenesis. Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | PPARgamma in cancer, Thyroid cancer |
| + |
ESR1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140233 |
|
|
Homo sapiens |
Breast Cancer Cell, MCF-7 Cell, HeLa Cell |
| pmid |
sentence |
| 16144913 |
Our data show for the first time that eralpha binds to ppar response element and represses its transactivation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
ABCG2 |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255054 |
|
|
Homo sapiens |
Dendritic Cell |
| pmid |
sentence |
| 16785230 |
these results uncovered a mechanism by which up-regulation of functional ABCG2 expression can be achieved via exogenous or endogenous activation of the lipid-activated transcription factor, PPARgamma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
IL10 |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271688 |
|
|
|
|
| pmid |
sentence |
| 20553736 |
Pigment epithelium-derived factor induces interleukin-10 expression in human macrophages by induction of PPAR gamma. |
|
| Publications: |
1 |
| Pathways: | Macrophage polarization |
| + |
dexamethasone | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235328 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TSC22D3 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253296 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 12671681 |
In this study, we showed that GILZ, which is transcriptionally induced by GCs, inhibits the transcription of the PPAR-γ2 gene and blocks adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Gbeta | down-regulates activity
relocalization
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270008 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18596912 |
The genomic activity of ppargamma is modulated, in addition to ligand binding, by phosphorylation of a serine residue by mapks, such as extracellular signal-regulated protein kinases-1/2 (erk-1/2), or by nucleocytoplasmic compartmentalization through the erk activators mapk kinases-1/2 (mek-1/2). These mapks phosphorylate (in humans) ser 84 in the ppargamma1 and ser 114 in ppargamma2 isoform |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF15 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.454 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235331 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 15664998 |
Moreover, KLF15 and C/EBPalpha acted synergistically to increase the activity of the PPARgamma2 gene promoter in 3T3-L1 adipocytes. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PRKACA | up-regulates activity
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253019 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 20638365 |
Here we showed that cAMP-induced activation of protein kinase A (PKA) and Akt is essential for the transcriptional activation of PPAR-gamma |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GATA3 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132955 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15632071 |
Constitutive expression of both gata-2 and gata-3 suppressed adipocyte differentiation, partially through direct binding to the peroxisome proliferator-activated receptor gamma (ppargamma) promoter and suppression of its basal activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
NR1D1 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268022 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 12821652 |
Mutations of the 5' or 3' half-sites of the response element totally abrogated PPARgamma binding and transcriptional activation, identifying this site as a novel type of functional PPARgamma response element. Finally, ectopic expression of Rev-Erbalpha in 3T3-L1 preadipocytes potentiated adipocyte differentiation induced by the PPARgamma ligand rosiglitazone. These results identify Rev-Erbalpha as a target gene of PPARgamma in adipose tissue and demonstrate a role for this nuclear receptor as a promoter of adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock |
| + |
mTORC1 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235343 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 19593385 |
Activation of mTORC1 causes a robust increase in the mRNA and protein expression of peroxisome proliferator-activated receptor gamma (PPARgamma), which is the master transcriptional regulator of adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.534 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249533 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20508200 |
Phosphorylated STAT6 dimerizes and translocates to the nucleus where it induces the expression of its target genes, including markers (Arg1, Chi3l3, Mrc1, Mgl1, and Retnla) and regulators (Pparalpha, Ppargamma and PGC-1?) of alternative activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide | down-regulates activity
chemical inhibition
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262015 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 27489280 |
We performed reporter assays to examine the effect of NeoB on the transcriptional activity of specific nuclear hormone receptors, including PPARs, retinoic acid receptor (RAR), ER, and LXR, in uninfected Huh7-25 cells (Fig. 3A). NeoB did not have a significant effect [...] in contrast to the transcriptional repression by known antagonists as positive controls (GW6471, GSK0660, FH535, Ro41-5253, and 4-hydroxytamoxifen) (Fig. 3A) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
miR-130a | down-regulates quantity
post transcriptional regulation
|
PPARG |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255760 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24057258 |
MiR-142-3p downregulated MLL-AF4 expression in the RS4;11 leukemic cell line. the downregulation of MLL-AF4 by ectopically expressed miR-142-3p reduced the expression of MLL-AF4 downstream target genes, including HOXA7, HOXA9, and HOXA10, which may contribute to miR-142-3p-induced apoptosis and growth inhibition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRDM16 | up-regulates
binding
|
PPARG |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180298 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 18719582 |
Prdm16 stimulates brown adipogenesis by binding to ppar-gamma (peroxisome-proliferator-activated receptor-gamma) and activating its transcriptional function |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
NCOA2 | up-regulates
binding
|
PPARG |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179175 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18584035 |
Collectively, our data provide the first evidence that erbeta-deficiency protects against diet-induced ir and glucose intolerance which involves an augmented ppargamma signaling in adipose tissue. Moreover, our data suggest that the coactivators src1 and tif2 are involved in this interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Prostate Cancer |
3.0
PPARG
- 
- 