Summary

Name GNA13
Full Name Guanine nucleotide-binding protein subunit alpha-13
Synonyms G alpha-13, G-protein subunit alpha-13
Primary ID Q14344
Links - -
Type protein
Relations 44
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation GNA13 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding, GNA13 0.34
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ARHGEF1 0.51
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA13 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png gtpase-activating protein, binding ARHGEF1 0.51
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA13 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ARHGEF11 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ARHGEF12 0.31
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding GNA13 0.31
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ up-regulates img/direct-activation.png binding GNA13 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RHOA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA13 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens