Summary

Name DVL1
Full Name Segment polarity protein dishevelled homolog DVL-1
Synonyms Dishevelled-1, DSH homolog 1
Primary ID O14640
Links - -
Type protein
Relations 36
Pathways WNT Signaling, WNT Signaling and Myogenesis, Wnt in cancer, Hepatocellular Tumor
Function Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation DVL1 0.36
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RND1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding DVL1 0.37
Publications: 2
Pathways:Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding DVL1 0.14
Publications: 1
Tissue: Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding DVL1 0.37
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png binding CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding GSK3B/Axin/APC 0.37
Publications: 3 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding DVL1 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AXIN1 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding DAAM1 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png RAC1 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding RAC1 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding APC 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RHOA 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png PLCB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding DVL1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png DVL1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png binding GSK3B 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png DVL1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding JUN 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination DVL1 0.34
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney