Summary

Name DVL1
Full Name Segment polarity protein dishevelled homolog DVL-1
Synonyms Dishevelled-1, DSH homolog 1
Primary ID O14640
Links - -
Type protein
Relations 32
Pathways WNT Signaling, WNT Signaling and Myogenesis, Wnt cancer
Function Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation DVL1 0.83
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DVL1
Publications: 2
Pathways:Wnt cancer, WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding DVL1 0.70
Publications: 1
Tissue: Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding DVL1
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Wnt cancer, WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png binding CTNNB1 0.27
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding DVL1
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png binding GSK3B/Axin/APC
Publications: 3 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding DVL1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL1 0.79
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png binding DVL1 0.62
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AXIN1 0.88
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png binding GSK3B 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown RAC1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png unknown DVL1 0.54
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding DAAM1 0.80
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding RAC1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding JUN 0.05
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding APC 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.62
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding DVL1 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown RND1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding DVL1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DVL1 0.56
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown DVL1 0.87
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding DVL1 0.65
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png ubiquitination DVL1 0.47
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png binding DVL1 0.64
Publications: 1 Organism: Homo Sapiens