Summary

Name SRC
Full Name Proto-oncogene tyrosine-protein kinase Src
Synonyms Proto-oncogene c-Src, pp60c-src, p60-Src | SRC1
Primary ID P12931
Links - -
Type protein
Relations 399
Pathways Axon guidance, EGFR Signaling, IL6 Signaling, Integrin Signaling, Rhabdomyosarcoma
Inhibitors Saracatinib; bosutinib; dasatinib (anhydrous); 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide; PD173955; ponatinib; KX2-391; PP2; herbimycin
Function Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.586
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SRC 0.585
Publications: 1 Organism: In Vitro
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.437
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRC 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRC 0.399
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ANXA1 0.398
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation VCL 0.749
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation ACLY 0.266
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.611
Publications: 4 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SIRT2 0.294
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FLT4 0.493
Publications: 6 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOXA1 0.414
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2A 0.581
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ARHGAP35 0.762
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CTNND1 0.921
Publications: 8 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.611
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation FHIT 0.477
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GAK 0.278
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation BCAR1 0.794
Publications: 14 Organism: Mus Musculus, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IGF1R 0.566
Publications: 5 Organism: In Vitro
Pathways:Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation IGF1R 0.566
Publications: 4 Organism: Homo Sapiens, In Vitro
Pathways:Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation TNS3 0.417
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SPTAN1 0.546
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MUC1 0.454
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation WASF1 0.413
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KCNB1 0.49
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRK2 0.2
Publications: 4 Organism: Homo Sapiens,
+ up-regulates img/direct-activation.png phosphorylation PAK2 0.547
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRIN2A 0.581
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DAPP1 0.571
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CAV1 0.753
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FBXO5 0.331
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EZR 0.631
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.573
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CLTC 0.415
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FLOT1 0.339
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS2 0.668
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ARHGDIB 0.4
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BAIAP2L1 0.395
Publications: 6 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIA 0.405
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ img/unknown.png phosphorylation GRB2 0.63
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, IL6 Signaling, Integrin Signaling, Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation ARHGEF4 0.316
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RGS16 0.354
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LASP1 0.254
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VAV3 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTTG1IP 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation BDKRB2 0.263
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DAB1 0.431
Publications: 4 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation KCNA3 0.314
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IKBKB 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IKBKB 0.37
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CAV2 0.666
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation WBP2 0.3
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FERMT2 0.374
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PKP3 0.309
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CHKA 0.341
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PANX1 0.383
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ANXA1 0.398
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CHN2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRC 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Axon guidance, EGFR Signaling, IL6 Signaling, Integrin Signaling, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation SHC3 (isoform 2)
Publications: 4 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STAP2 0.415
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPK 0.606
Publications: 6 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ABL1 0.521
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RACK1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HNF4A 0.37
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DNM1 0.622
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation ANXA2 0.56
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MPZL1 0.479
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GAB1 0.691
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation GJA1 0.604
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GTF2I 0.463
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation CASP9 0.379
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation RHOU 0.532
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation VIL1 0.371
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.691
Publications: 4 Organism: Homo Sapiens
Pathways:EGFR Signaling, Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation PRKCI 0.516
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TGFBR2 0.283
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HSP90AB1 0.57
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ARAF 0.468
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation ARAF 0.468
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:EGFR Signaling
+ down-regulates img/direct_inhibition.png phosphorylation PPP2CA 0.437
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT 0.665
Publications: 3 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:EGFR Signaling, Integrin Signaling, Rhabdomyosarcoma
+ img/unknown.png phosphorylation SH3GL1 0.621
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.665
Publications: 3 Organism: Homo Sapiens, Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation SH3GL1 0.621
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PDCD6IP 0.402
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HRAS 0.765
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Integrin Signaling
+ up-regulates img/direct-activation.png phosphorylation WWOX 0.491
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.751
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation DGKA 0.47
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KCNJ1 0.316
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RHOA 0.652
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.59
Publications: 4 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates activity img/direct-activation.png phosphorylation YAP1 (isoform 3)
Publications: 3 Organism: Yellow Fever Virus 17D
+ up-regulates img/direct-activation.png phosphorylation CBLC 0.554
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HLA-A 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.654
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR Signaling, IL6 Signaling
+ up-regulates img/direct-activation.png phosphorylation CYP19A1 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PDPK1 0.569
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR Signaling, Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.461
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CHRNA7 0.2
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KRT19 0.292
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.637
Publications: 8 Organism: Homo Sapiens
Pathways:Axon guidance, Integrin Signaling
+ up-regulates img/direct-activation.png phosphorylation PTK2B 0.611
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GSN 0.573
Publications: 4 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.54
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.59
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.469
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.64
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.771
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.311
Publications: 2 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.675
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TXK 0.355
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTTN 0.792
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PRKD1 0.42
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GLRB 0.272
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ up-regulates img/direct-activation.png phosphorylation UGT2B7 0.348
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ENO1 0.421
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTTN 0.792
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP1 0.402
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS6KB2 0.349
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation VAMP7 0.289
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation LRP1 0.402
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation AFAP1 0.587
Publications: 4 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation MYLK 0.426
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GSN 0.573
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HCN2 0.27
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS6KA3 0.362
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLEKHG2 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PLEKHG2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CEACAM1 0.435
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAPGEF1 0.656
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NECTIN2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SH3PXD2B 0.519
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DLG4 0.579
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.362
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SRC 0.638
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.411
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png dephosphorylation SRC 0.732
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.732
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SRC 0.554
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SRC 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance, EGFR Signaling, IL6 Signaling, Integrin Signaling, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.54
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation SRC 0.629
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.445
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png dephosphorylation SRC 0.771
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.629
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.64
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.62
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation HCN4 0.376
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTPN6 0.54
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.769
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARRB1 0.671
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SPRY2 0.546
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BTK 0.511
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BMX 0.518
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MMP14 0.442
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EMD 0.461
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png phosphorylation EPHA2 0.431
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CELF2 0.327
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CDC42 0.68
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates activity img/direct-activation.png phosphorylation JUP 0.655
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIP5K1C 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FCRL3 0.2
Publications: 4 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CTNNB1 0.751
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates activity img/direct_inhibition.png phosphorylation CDH5 0.58
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png phosphorylation RRAS 0.563
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GRB10 0.457
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT5B 0.593
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CFL1 0.567
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates img/direct-activation.png phosphorylation CDH5 0.58
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates activity img/direct-activation.png phosphorylation PLSCR1 0.487
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT5A 0.739
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.573
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.779
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:EGFR Signaling, IL6 Signaling, Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation TERT 0.428
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CDCP1 0.541
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DDR2 0.389
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AP2B1 0.275
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.507
Publications: 3 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates activity img/direct-activation.png phosphorylation CORO7 0.346
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGB3 0.648
Publications: 2 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates activity img/direct-activation.png phosphorylation PLCG1 0.622
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDH1 0.744
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation PTPRA 0.732
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATG9A 0.346
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PROM1 0.512
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDH2 0.403
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.751
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation PXN 0.799
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ down-regulates img/direct_inhibition.png phosphorylation DAG1 0.534
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png phosphorylation PDPK1 0.569
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation KIT 0.394
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKD1 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation INPPL1 0.549
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SRCIN1 0.508
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGB2 0.437
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GlyR 0.272
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ down-regulates activity img/direct_inhibition.png chemical inhibition SRC 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.8
Publications: 2 Organism: Homo Sapiens
Tissue: Myotube, Brain
+ up-regulates img/direct-activation.png phosphorylation RAC1 0.598
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation SRC 0.287
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SRC 0.55
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SRC 0.373
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding SRC 0.516
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates img/direct-activation.png phosphorylation KRAS 0.642
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation SRC 0.273
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png binding SRC 0.26
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SRC 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage TGFA 0.303
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates img/direct-activation.png binding SRC 0.429
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ up-regulates img/indirect-activation.png MAPK7 0.35
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation SH3PXD2A 0.644
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation Enolase 0.423
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png TGFA 0.303
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png binding SRC 0.374
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SRC 0.355
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SRC 0.709
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGAL 0.408
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SRC 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png SRC 0.46
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation IKK-complex 0.385
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SRC 0.51
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RASA1 0.601
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TIAM1 0.643
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRC 0.324
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png SRC 0.444
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation SRC 0.417
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SRC 0.489
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding SRC 0.464
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation GlyR 0.272
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ down-regulates img/direct_inhibition.png phosphorylation PTEN 0.548
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SRC 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation LATS1/2 0.391
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation SRC 0.294
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MMP3 0.344
Publications: 1
+ up-regulates img/direct-activation.png cleavage AREG 0.349
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling