Summary

Name PTPN11
Full Name Tyrosine-protein phosphatase non-receptor type 11
Synonyms Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3 | PTP2C, SHPTP2
Primary ID Q06124
Links - -
Type protein
Relations 55
Pathways Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, AML_TRIPLETS, EGFR Signaling, FLT3-ITD signaling, Leptin Signaling, NPM1_new, Noonan syndrome
Inhibitors 8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid; 8-oxo-7-[(6-sulfo-2-naphthalenyl)hydrazinylidene]-5-quinolinesulfonic acid
Function Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation PTPN11 0.336
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN11 0.312
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN11 0.329
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT1 0.733
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation JAK2 0.786
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, EGFR Signaling, Leptin Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.865
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Noonan syndrome
+ down-regulates img/direct_inhibition.png dephosphorylation ERBB2 0.831
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation IRS1 0.892
Publications: 4 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation CTNNA1 0.405
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MPZL1 0.542
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN11 0.758
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation PTPN11 0.786
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, EGFR Signaling, Leptin Signaling
+ up-regulates activity img/direct-activation.png dephosphorylation KRAS 0.646
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD signaling, Noonan syndrome
+ up-regulates activity img/direct-activation.png dephosphorylation NRAS 0.661
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, AML_TRIPLETS, NPM1_new, Noonan syndrome
+ up-regulates activity img/direct-activation.png dephosphorylation HRAS 0.669
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Noonan syndrome
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.635
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.635
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation PTPN11 0.736
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation PTK2 0.719
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation GAB1 0.951
Publications: 3 Organism: Homo Sapiens
Pathways:EGFR Signaling, Noonan syndrome
+ down-regulates img/direct_inhibition.png dephosphorylation GAB2 0.733
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation GAB1 0.951
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR Signaling, Noonan syndrome
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.761
Publications: 1 Organism: Canis Lupus Familiaris
Pathways:Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, FLT3-ITD signaling, Leptin Signaling
+ up-regulates img/direct-activation.png dephosphorylation MAP3K5 0.375
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDGFRB 0.736
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png dephosphorylation HOXA10 0.381
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PTPN11 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GRB2 0.721
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, EGFR Signaling, Noonan syndrome
+ up-regulates img/direct-activation.png phosphorylation PTPN11 0.771
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PTPN11 0.486
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ down-regulates activity img/direct_inhibition.png chemical inhibition PTPN11 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN11 0.669
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates activity img/direct_inhibition.png binding PTPN11 0.366
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png ERK1/2 0.861
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, AML_TRIPLETS, EGFR Signaling, FLT3-ITD signaling, Leptin Signaling, NPM1_new, Noonan syndrome
+ down-regulates img/direct_inhibition.png dephosphorylation SPRY1 0.422
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome
+ down-regulates activity img/direct_inhibition.png dephosphorylation α-Catenin 0.405
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PTPN11 0.393
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png relocalization PTPN11 0.382
Publications: 1 Organism: Canis Lupus Familiaris
+ up-regulates img/direct-activation.png dephosphorylation CSF2RB 0.483
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PTPN11 0.545
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML, AML_TRIPLETS, FLT3-ITD signaling, NPM1_new