Summary

Name PRKCA
Full Name Protein kinase C alpha type
Synonyms PKC-A, PKC-alpha | PKCA, PRKACA
Primary ID P17252
Links - -
Type protein
Relations 380
Pathways Axon guidance, B-cell activation, Mitochondrial dynamics in T cell exhaustion, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
Inhibitors midostaurin; 3-(1-methyl-3-indolyl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-3-indolyl]pyrrole-2,5-dione; bisindolylmaleimide i
Function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteosomal degradation (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation VIM 0.29
Publications: 10 Organism: In Vitro
+ img/unknown.png phosphorylation MARCKS 0.72
Publications: 9 Organism: In Vitro, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KCNE1 0.31
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PEA15 0.394
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ img/unknown.png phosphorylation INSR 0.354
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation FMNL2 0.2
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation CD163 0.328
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HAND1 0.291
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation VCL 0.4
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PLCB3 0.455
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLEK 0.286
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TRPM4 0.2
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SRC 0.579
Publications: 1 Organism: In Vitro
Pathways:Axon guidance
+ up-regulates img/direct-activation.png phosphorylation KCNMA1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PLCG1 0.535
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation, VEGF Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation GFAP 0.376
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.485
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation EGLN2 0.338
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ITGB4 0.504
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DLX3 0.31
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation DLX3 0.31
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.412
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation HSPB8 0.311
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation HSPB8 0.311
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MBP 0.506
Publications: 7 Organism: In Vitro
+ img/unknown.png phosphorylation GRIN2A 0.524
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation IQGAP1 0.262
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NR1H4 0.335
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TBXA2R (isoform 2) 0.494
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1A 0.39
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MARCKS 0.72
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation GNAZ 0.413
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates activity img/direct_inhibition.png phosphorylation ATP1A1 0.334
Publications: 1 Organism: Mycolicibacterium Chitae
+ img/unknown.png phosphorylation SNAP23 0.334
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SRF 0.249
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation TRPV4 0.352
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MBD4 0.2
Publications: 2
+ down-regulates activity img/direct_inhibition.png phosphorylation TNNI3 0.349
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation, RPL10 0.31
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation NOXA1 0.293
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAB11A 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SDC4 0.721
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation CDC42EP4 0.2
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SDC2 0.379
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation SNAP25 0.359
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SNAP25 0.359
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RALB 0.297
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CORO1B 0.329
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLD1 0.702
Publications: 3 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation MYL9 0.284
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KCNJ13 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GFPT1 0.31
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation EIF4E 0.392
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation HMGN1 0.31
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3A 0.352
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RRAD 0.291
Publications: 5 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation FLNC 0.344
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation GJB1 0.368
Publications: 2 Organism: In Vitro,
+ up-regulates activity img/direct-activation.png phosphorylation TNNI3 0.349
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CFL1 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Axon guidance
+ img/unknown.png phosphorylation RAF1 0.534
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EIF6 0.326
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SLC6A9 (isoform 2) 0.337
Publications: 5 Organism: Sus Scrofa
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.401
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLD2 0.678
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HMGN2 0.293
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HDAC5 0.2
Publications: 2 Organism: Rattus Norvegicus
+ img/unknown.png phosphorylation ANXA2 0.363
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GJA1 0.554
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DGKZ 0.522
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation EWSR1 0.336
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation IL2RA 0.269
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ANXA1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PITPNC1 0.327
Publications: 2 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation F11R 0.326
Publications: 2 Organism: Homo Sapiens, In Vitro
+ up-regulates img/direct-activation.png phosphorylation F3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ICOSLG 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRK2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NFATC1 0.393
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SHOC2 0.2
Publications: 2
+ up-regulates activity img/direct-activation.png phosphorylation TRPV5 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1 0.535
Publications: 8 Organism: Homo Sapiens
+ img/unknown.png phosphorylation STXBP1 0.386
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIB 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CLIP1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PDE3A 0.2
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TACSTD2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT (isoform 2) 0.27
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation SPAG1 0.31
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PTGIR 0.328
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1R16B 0.2
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation RHO 0.453
Publications: 6 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation OCLN 0.371
Publications: 1 Organism: Canis Lupus Familiaris
+ img/unknown.png phosphorylation OPRD1 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PSEN1 0.269
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RORA 0.256
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation UNC5A 0.2
Publications: 2 Organism: Rattus Norvegicus
Pathways:Axon guidance
+ img/unknown.png phosphorylation HLA-A 0.327
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation NRGN 0.404
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PA2G4 0.444
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GJA1 0.554
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation HES1 0.334
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.451
Publications: 1 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation VTN 0.323
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PTPN12 0.326
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation VIM 0.29
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation CYTH2 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ADRA1B 0.4
Publications: 5 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation HRH1 0.2
Publications: 3 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation NFE2L2 0.51
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LMNA 0.369
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PIP5K1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TNNI3 0.349
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ img/unknown.png phosphorylation LCK 0.328
Publications: 1 Organism: In Vitro
Pathways:T cell activation
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.534
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation UGT1A3 0.2
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation GABRR1 0.341
Publications: 4 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation LRP1 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTPS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHAT 0.393
Publications: 5 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS6KB2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NKX3-1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FERMT3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.534
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation THOC5 0.332
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation LMNA 0.369
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation KRT18 0.311
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation GMFB 0.327
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation NOX5 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KCNQ2 0.329
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png phosphorylation DDX5 0.341
Publications: 1 Organism: In Vitro
+ up-regulates quantity img/direct-activation.png phosphorylation KCNQ2 0.329
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png phosphorylation PTPN6 0.372
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN11 0.329
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CBL 0.326
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.369
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates quantity img/direct_inhibition.png dephosphorylation PRKCA 0.257
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCA 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Axon guidance, B-cell activation, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
+ down-regulates quantity img/direct_inhibition.png dephosphorylation PRKCA 0.254
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DGKD 0.374
Publications: 2 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation GRIA2 0.697
Publications: 3 Organism: In Vitro, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CFTR 0.41
Publications: 2 Organism: In Vitro
+ down-regulates quantity img/direct_inhibition.png phosphorylation MEP1B 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ADD3 0.339
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.356
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TRPC3 0.353
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png phosphorylation ACO1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png phosphorylation ADD2 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ADD1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation PRKD1 0.418
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KIT 0.504
Publications: 4 Organism: Sus Scrofa
+ down-regulates img/direct_inhibition.png phosphorylation KIT 0.504
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN2D 0.2
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TNNI3 0.349
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation DNM1 0.339
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation GRIA1 0.703
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.427
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation GRIA4 0.547
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ADAP1 0.322
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation PLCB1 0.702
Publications: 1 Organism: Mus Musculus
Pathways:Thyroid Hormone Metabolism
+ up-regulates activity img/direct-activation.png phosphorylation GRIN1 0.429
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.364
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPA1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MET 0.259
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GPM6A 0.328
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation NPHS1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MYOD1 0.371
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation DLX3 0.31
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CYBA 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation AQP1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation SRF 0.249
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation RAB37 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CSPG4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RALBP1 0.399
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation NOXO1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HABP4 0.293
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R14A 0.5
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CD5 0.346
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CD5 0.346
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTPS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.446
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS3 0.308
Publications: 1 Organism: Homo Sapiens
Pathways:VEGF Signaling
+ up-regulates img/direct-activation.png phosphorylation EZR 0.527
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKG1 0.35
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.587
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GRM1 0.394
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation APLP2 0.346
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation ITGB2 0.347
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRIA4 0.547
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CASR 0.358
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EDF1 0.305
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKCA 0.401
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates img/direct-activation.png phosphorylation PRKCA 0.535
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation, VEGF Signaling
+ up-regulates img/direct-activation.png chemical activation PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, VEGF Signaling
+ up-regulates activity img/direct-activation.png relocalization PRKCA 0.474
Publications: 1
+ img/unknown.png phosphorylation AMPA 0.703
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PRKCA 0.8
Publications: 1
+ down-regulates activity img/direct_inhibition.png ITPKB 0.367
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding, chemical activation PRKCA 0.8
Publications: 4 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
+ up-regulates img/direct-activation.png chemical activation PRKCA 0.8
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Axon guidance, B-cell activation, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PRKCA 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PRKCA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PRKCA 0.424
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLA2G4A 0.556
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Cell_death 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PRKCA 0.402
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CREBBP 0.265
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates activity img/direct-activation.png chemical activation PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PRKCA 0.413
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PRKCA 0.796
Publications: 1 Organism: Rattus Norvegicus
Pathways:Axon guidance
+ img/unknown.png NOS1 0.486
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation RGS7 0.372
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PRKCA 0.413
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCA 0.387
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation, VEGF Signaling
+ up-regulates activity img/direct-activation.png binding PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PRKCA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PRKCA 0.399
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ITPKA 0.378
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation MGluR 0.573
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png chemical activation PRKCA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, Thyroid Hormone Metabolism, VEGF Signaling
+ down-regulates img/indirect_inhibition.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens