Summary

Name MYOD1
Full Name Myoblast determination protein 1
Synonyms Class C basic helix-loop-helix protein 1, bHLHc1, Myogenic factor 3, Myf-3 | BHLHC1, MYF3, MYOD
Primary ID P15172
Links - -
Type protein
Relations 95
Pathways Myostatin, Satellite: TNFA, IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, WNT Signaling and Myogenesis, Rhabdomyosarcoma, Satellite: NOTCH, Satellite: WNT, Satellite: myogenic transcriptional cascade, Satellite: FST transcriptional regulation
Function Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation MYOD1 0.07
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYOD1
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYOD1
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation MYOD1 0.09
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MYOD1 0.09
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation MYOD1 0.07
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma, Satellite: myogenic transcriptional cascade
+ up-regulates img/direct-activation.png binding MYOD1 0.09
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png unknown MYOD1 0.13
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding MYOD1
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDKN1A
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FST
Publications: 1 Organism: Mus Musculus
Pathways:Myostatin, Satellite: FST transcriptional regulation
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYH7 0.09
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding MYOD1
Publications: 1 Organism: Mus Musculus
Pathways:Myostatin
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYOD1 0.22
Publications: 2 Organism: Mus Musculus,
Tissue: Muscle
Pathways:NOTCH Signaling and Myogenesis, Satellite: NOTCH
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown MYOD1 0.16
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png post transcriptional regulation MYOD1
Publications: 1
Pathways:Satellite: TNFA
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYOD1 0.34
Publications: 1
Pathways:NOTCH Signaling and Myogenesis, Satellite: NOTCH
+ up-regulates activity img/direct-activation.png binding MYOD1 0.05
Publications: 2 Organism: , Homo Sapiens
Tissue: Muscle
Pathways:Rhabdomyosarcoma, Satellite: WNT, WNT Signaling and Myogenesis
+ down-regulates quantity by destabilization img/indirect_inhibition.png binding MYOD1 0.29
Publications: 1
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma, Satellite: TNFA, Satellite: myogenic transcriptional cascade, Satellite: NOTCH
+ down-regulates quantity by destabilization img/indirect_inhibition.png binding PAX7 0.29
Publications: 1
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma, Satellite: TNFA, Satellite: myogenic transcriptional cascade, Satellite: NOTCH
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYOG 1.00
Publications: 2
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma, Satellite: myogenic transcriptional cascade
+ down-regulates img/direct_inhibition.png binding MYOD1
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis, Rhabdomyosarcoma
+ up-regulates img/direct-activation.png acetylation, binding MYOD1
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding SWI/SNF complex
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates img/direct_inhibition.png binding MYOD1 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation MYOD1 0.23
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/indirect-activation.png unknown MYOD1 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Satellite: TNFA
+ down-regulates img/direct_inhibition.png binding MYOD1 0.26
Publications: 1 Organism: Mus Musculus
Tissue: Muscle
+ up-regulates img/direct-activation.png binding SMARCD3 0.23
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding MYOD1
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding MYOD1 0.19
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYOD1 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding MYOD1 0.23
Publications: 1 Organism: In Vitro
Pathways:P38 Signaling and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CCND3 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN1A 0.08
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation RB1 0.09
Publications: 1 Organism: Mus Musculus
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png binding MYOD1 0.24
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.10
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.29
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma, Satellite: TNFA, Satellite: myogenic transcriptional cascade, Satellite: NOTCH
+ up-regulates activity img/direct-activation.png binding MYOD1 0.41
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding MYOD1 0.53
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates img/indirect-activation.png unknown MYOD1 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png acetylation MYOD1 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png acetylation, binding MYOD1 0.39
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png binding MYOD1 0.25
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding MYOD1 0.15
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png binding MYOD1 0.44
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png unknown MYOD1 0.24
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/indirect-activation.png unknown MYOD1 0.16
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding MYOD1 0.74
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding MYOD1 0.23
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding MYOD1 0.29
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MYOD1 0.66
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.12
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png ubiquitination MYOD1 0.26
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis, Myostatin
+ down-regulates img/direct_inhibition.png deacetylation MYOD1 0.19
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/indirect-activation.png unknown MYOD1 0.20
Publications: 2 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
Pathways:Satellite: WNT, WNT Signaling and Myogenesis
+ up-regulates activity img/indirect-activation.png unknown MYOD1 0.15
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Satellite: WNT, WNT Signaling and Myogenesis
+ up-regulates img/indirect-activation.png unknown CDKN1A 0.08
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle, Myotube
Pathways:Rhabdomyosarcoma
+ form complex img/form-complex.png binding MYOD/E2-2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MYOD/HEB
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ITGA7 0.20
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.07
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.12
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding MYOD/E12E47
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation VEGFA 0.02
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation DES 0.42
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SP1 0.10
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation MYOD1 0.10
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.10
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Satellite: FST transcriptional regulation, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png transcriptional regulation MYOD1 0.22
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling and Myogenesis, Satellite: NOTCH
+ up-regulates activity img/direct-activation.png binding MYOD1 0.21
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png unknown Skeletal Muscle Differentiation
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis, Myostatin, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma, WNT Signaling and Myogenesis
+ form complex img/form-complex.png binding MYOD1/SWI/SNF complex
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png binding SMARCA4 0.27
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MYOD1
Publications: 1 Organism: Homo Sapiens
Tissue: C2C12 Cell
Pathways:NOTCH Signaling and Myogenesis, Satellite: NOTCH
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.09
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.23
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma, WNT Signaling and Myogenesis
+ down-regulates img/indirect_inhibition.png unknown MYOD1 0.01
Publications: 1 Organism: Homo Sapiens
Tissue: Myotube
+ up-regulates img/indirect-activation.png unknown MYOD1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYOD1
Publications: 1 Organism: Homo Sapiens