| + |
GSK3B | up-regulates 
phosphorylation
|
CEBPB |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156514 |
Ser231 |
LSTSSSSsPPGTPSP |
Homo sapiens |
|
| pmid |
sentence |
| 17601773 |
Mass spectrometric analysis revealed that cdk2/cyclinA phosphorylates C/EBPbeta on Thr(188) and is required for phosphorylation (on Ser(184) or Thr(179)) of C/EBPbeta by GSK3beta and maintenance of DNA binding activity. However, the acquisition of dna binding and transactivation capacity of c/ebpbeta is delayed until further phosphorylation (on ser(184) or thr(179)) by gsk3beta occurs. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196377 |
Ser231 |
LSTSSSSsPPGTPSP |
Homo sapiens |
|
| pmid |
sentence |
| 22369944 |
However, the acquisition of dna binding and transactivation capacity of c/ebpbeta is delayed until further phosphorylation (on ser(184) or thr(179)) by gsk3beta occurs. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210129 |
Thr226 |
GSSGSLStSSSSSPP |
Homo sapiens |
|
| pmid |
sentence |
| 22369944 |
However, the acquisition of dna binding and transactivation capacity of c/ebpbeta is delayed until further phosphorylation (on ser(184) or thr(179)) by gsk3beta occurs. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling |
| + |
CAMK2A | up-regulates activity
phosphorylation
|
CEBPB |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250617 |
Ser325 |
EQLSRELsTLRNLFK |
in vitro |
|
| pmid |
sentence |
| 1314426 |
These studies implicate Ser276 of CIEBPP as the major in vim phosphorylation site for CaMKII. | Phosphorylation of serine at position 276 within the leucine zipper of C/EBP beta appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBP beta. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CDK2 | up-regulates
phosphorylation
|
CEBPB |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196372 |
Thr235 |
SSSSPPGtPSPADAK |
Homo sapiens |
|
| pmid |
sentence |
| 22369944 |
Mass spectrometric analysis revealed that cdk2/cyclina phosphorylates c/ebpbeta on thr(188) and is required for phosphorylation (on ser(184) or thr(179)) of c/ebpbeta by gsk3beta and maintenance of dna binding activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156509 |
Thr235 |
SSSSPPGtPSPADAK |
Homo sapiens |
|
| pmid |
sentence |
| 17601773 |
Mass spectrometric analysis revealed that cdk2/cyclina phosphorylates c/ebpbeta on thr(188) and is required for phosphorylation (on ser(184) or thr(179)) of c/ebpbeta by gsk3beta and maintenance of dna binding activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis |
| + |
MAPK1 | up-regulates
phosphorylation
|
CEBPB |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187798 |
Thr235 |
SSSSPPGtPSPADAK |
Homo sapiens |
|
| pmid |
sentence |
| 19723873 |
Phosphorylation of cebpb at thr(235) peaked at 16 hours in il-1beta-stimulated cells. The mek inhibitor u0126 inhibited this phosphorylation and reduced mmp-1 gene induction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinA2/CDK2 | up-regulates
phosphorylation
|
CEBPB |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217312 |
Thr235 |
SSSSPPGtPSPADAK |
Homo sapiens |
|
| pmid |
sentence |
| 17601773 |
Mass spectrometric analysis revealed that cdk2/cyclina phosphorylates c/ebpbeta on thr(188) and is required for phosphorylation (on ser(184) or thr(179)) of c/ebpbeta by gsk3beta and maintenance of dna binding activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217316 |
Thr235 |
SSSSPPGtPSPADAK |
Homo sapiens |
|
| pmid |
sentence |
| 22369944 |
Mass spectrometric analysis revealed that cdk2/cyclina phosphorylates c/ebpbeta on thr(188) and is required for phosphorylation (on ser(184) or thr(179)) of c/ebpbeta by gsk3beta and maintenance of dna binding activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates activity
phosphorylation
|
CEBPB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238303 |
Thr235 |
SSSSPPGtPSPADAK |
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 19723873 |
Phosphorylation of cebpb at thr(235) peaked at 16 hours in il-1beta-stimulated cells. The mek inhibitor u0126 inhibited this phosphorylation and reduced mmp-1 gene induction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling |
| + |
GSK3B | up-regulates activity
phosphorylation
|
CEBPB |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251644 |
Thr235 |
SSSSPPGtPSPADAK |
Mus musculus |
3T3-F442A Cell |
| pmid |
sentence |
| 22355693 |
We found that expression of srebf1a depended on GSK3β activity and that GSK3β activity was necessary for C/EBPβ phosphorylation at Thr188 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling |
| + |
MAPK3 | up-regulates
phosphorylation
|
CEBPB |
0.667 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184917 |
Thr235 |
SSSSPPGtPSPADAK |
Homo sapiens |
|
| pmid |
sentence |
| 19327116 |
Thr235 phosphorylation occurs in nuclei of differentiated macrophages, but not in monocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates
phosphorylation
|
CEBPB |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186423 |
Tyr78 |
RAIDFSPyLEPLGAP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19563810 |
The y79 amino acid residue of c/ebpbeta was phosphorylated by c-abl or arg. The phosphorylation of c/ebpbeta resulted in an increased c/ebpbeta stability and a potentiation of c/ebpbeta transcription activation activity in cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL2 | up-regulates
phosphorylation
|
CEBPB |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186427 |
Tyr78 |
RAIDFSPyLEPLGAP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19563810 |
The y79 amino acid residue of c/ebpbeta was phosphorylated by c-abl or arg. The phosphorylation of c/ebpbeta resulted in an increased c/ebpbeta stability and a potentiation of c/ebpbeta transcription activation activity in cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3-isobutyl-1-methylxanthine | up-regulates quantity by expression 
|
CEBPB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43310 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8754811 |
The differentiation of 3t3 preadipocytes into adipocytes is accompanied by a transient induction of c/ebpbeta and c/ebpdelta expression in response to treatment of the cells with methylisobutylxanthine (mix) and dexamethasone (dex), respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity by expression
transcriptional regulation
|
CEBPB |
0.461 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256117 |
|
|
Mus musculus |
Preadipocyte Cell Line |
| pmid |
sentence |
| 27777311 |
We show that in addition, DEX-bound GR directly promotes the expression of adipogenic TFs, including C/EBPβ, Klf5, Klf9, and C/EBPα. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
SMAD1/4 | up-regulates activity
binding
|
CEBPB |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253552 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18854943 |
This Smad1/4 complex can directly interact with Shn-2 and C/EBP a on the PPAR g promoter thus, resulting in the transcriptional activation of PPAR g |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity
transcriptional regulation
|
SREBF1 |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251645 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22355693 |
These results show that GSK3β is involved in regulating phosphorylation and activation of C/EBPβ and that this transcription factor is required to transactivate srebf1a expression, leading to the early steps of adipogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
PCK2 |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253773 |
|
|
Homo sapiens |
Hepatoma Cell |
| pmid |
sentence |
| 8093246 |
C/EBP beta can regulate PEPCK gene transcription by acting through the CRE and that C/EBP beta, together with CREB, may contribute to the cAMP responsiveness of the PEPCK promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD3 | down-regulates activity 
binding
|
CEBPB |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250567 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12524424 |
Thus, repression of the activity of C/EBPs by Smad3/4 at C/EBP binding sites inhibited transcription from the PPAR2 and leptin promoters |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
SFTPD |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254045 |
|
|
Homo sapiens |
NCI-H441 Cell |
| pmid |
sentence |
| 11912209 |
Cotransfection of C/EBPalpha, C/EBPbeta, or C/EBPdelta cDNA in H441 lung adenocarcinoma cells significantly increased the luciferase activity of a wild-type SP-D promoter construct containing 698 bp of upstream sequence (SS698). Transfection of C/EBP also increased the level of endogenous SP-D mRNA in H441 cells| Thus, interactions among C/EBP elements in the near-distal promoter can modulate the promoter activity of SP-D. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
GOT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254051 |
|
|
|
|
| pmid |
sentence |
| 8454627 |
In cotransfection experiments, the C/EBP beta protein trans-activated 10-15-fold the cAspAT gene promoter in HepG2 cells. Deletion studies revealed that regions P2 and P4 are critical for promoter activity. In gel retardation experiments, the P4 region bound different C/EBP-related proteins in different tissues |
|
| Publications: |
1 |
| + |
CEBPB | down-regulates quantity by repression 
transcriptional regulation
|
GFER |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253772 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 20690902 |
In the present study, we investigated transcription of hHSS triggered by EGF (epidermal growth factor) and the role of C/EBPβ (CCAAT/enhancer-binding protein β) as a potential core factor responsible for hHSS transcription in HepG2 cells. The results show that EGF suppresses hHSS mRNA expression at early time points. Using a promoter deletion assay, we identified a proximal region (-358/-212) that is required for EGF suppression. Overexpression of C/EBPβ enhances EGF suppression of hHSS, and mutation of the C/EBPβ-binding site at -292/-279 or siRNA (short interfering RNA) interference abolishes EGF suppression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
miR-155 | down-regulates quantity
post transcriptional regulation
|
CEBPB |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255770 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25477897 |
MiR-155 directly inhibits src homology 2 domaincontaining inositol-5-phosphatase (SHIP1) as well as CCAATenhancer-binding protein-beta (CEBP-β) to mediate leukemogenesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
CEBPB | up-regulates activity
binding
|
CREB1 (isoform 1) |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263654 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 12773552 |
We conclude that C/EBP-β can directly bind to the N-terminal Q1 domain of CREB in addition to binding to the leucine zipper domain. The transactivation potential of full-length CREB fused to the DNA-binding domain of Gal4 was increased synergistically by calcium and cGMP, and overexpression of C/EBP-β enhanced the effect, while a dominant negative C/EBP inhibited it |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
FLT3 | down-regulates quantity by repression
transcriptional regulation
|
CEBPB |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250563 |
|
|
|
|
| pmid |
sentence |
| 16146838 |
Oncogenic mutations of Flt3 also result in the activation of aberrant signaling pathways, including strong activation of STAT5, induction of STAT target genes, and repression of myeloid transcription factors c/EBP-3 and Pu.1. |
|
| Publications: |
1 |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML, FLT3-ITD signaling |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
KLF5 |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210004 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16054042 |
Klf5 expression is induced by c/ebpbeta and delta. KLF5, in turn, acts in concert with c/ebpbeta/delta to activate the ppargamma2 promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
CEBPB |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250573 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 14593102 |
Expression of constitutively active CREB strongly activated C/EBPbeta promoter-reporter genes, induced expression of endogenous C/EBPbeta, and caused adipogenesis in the absence of the hormonal inducers normally required |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis, FLT3-ITD signaling |
| + |
dexamethasone | up-regulates
|
CEBPB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106472 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238297 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25451943 |
Adipogenesis is controlled by a transcriptional cascade composed of a large number of transcriptional factors, among which CCAAT/enhancer-binding protein (C/EBP) β plays an essential role. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250564 |
|
|
|
|
| pmid |
sentence |
| 11884404 |
Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, |
| Pathways: | Adipogenesis |
| + |
DDIT3 | down-regulates quantity
transcriptional regulation
|
CEBPB |
0.669 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255914 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 7588595 |
We find that expression of CHOP, a nuclear protein that dimerizes avidly with C/EBP isoforms alpha and beta and directs the resulting heterodimer away from classic C/EBP-binding sites, markedly inhibits this differentiation process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
3-isobutyl-1-methylxanthine | up-regulates
|
CEBPB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106481 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COP1 | down-regulates quantity by destabilization
ubiquitination
|
CEBPB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261924 |
|
|
Mus musculus |
Microglia |
| pmid |
sentence |
| 32795415 |
We show expression of c/EBPβ in microglia is regulated post-translationally by the ubiquitin ligase COP1 (also called RFWD2). In the absence of COP1, c/EBPβ accumulates rapidly and drives a potent pro-inflammatory and neurodegeneration-related gene program, evidenced by increased neurotoxicity in microglia-neuronal co-cultures. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
C3 |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261927 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25617152 |
CCAAT/enhancer binding protein β directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
IL10 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254523 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12493739 |
The C/EBP5 motif, which is located between the TATA-box and the translation start point, is essential for the C/EBP-mediated constitutive and most of the cAMP-stimulated expression as its mutation nearly abolished IL-10 promoter activity. Our results suggest a dominant role of C/EBP transcription factors relative to CREB/ATF in tissue-specific and differentiation-dependent IL-10 transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
STAR |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254046 |
|
|
Homo sapiens |
Endometrial Stromal Cell |
| pmid |
sentence |
| 18583320 |
Electrophoretic mobility shift assay demonstrated that this region of the StAR promoter was bound by C/EBPalpha, C/EBPbeta, and CREB. Forced expression of either C/EBPalpha or C/EBPbeta alone was sufficient to up-regulate StAR promoter activity whereas PGE(2) was needed to induce StAR promoter activity in CREB-overexpressed cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
CSRP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254049 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 14522018 |
We conclude that c-Rel regulates CRP expression without the requirement of binding to a kappaB site, and binds directly to C/EBPbeta to facilitate the binding of C/EBPbeta to the CRP promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | down-regulates
transcriptional regulation
|
CEBPB |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210037 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19254573 |
Sox9 directly binds to the promoter regions of c/ebpbeta and c/ebpdelta to suppress their promoter activity, preventing adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity
transcriptional regulation
|
PPARG |
0.728 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143952 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16431920 |
These data suggest that c/CEBP beta activates a single unified pathway of adipogenesis involving its stimulation of PPARgamma expression, which then activates C/EBP alpha expression by dislodging HDAC1 from the promoter for degradation in the proteasome |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255730 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 7557387 |
Induction of C/EBP beta DNA-binding activity in NIH-3T3 beta 2 cells exposed to dexamethasone in the presence of insulin and fetal bovine serum activates the expression of an adipocyte-specific nuclear hormone receptor, PPAR gamma, that stimulates the conversion of these fibroblasts into committed preadipocytes |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
SMAD3/SMAD4 | down-regulates activity
binding, transcriptional regulation
|
CEBPB |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12524424 |
C/EBPbeta and C/EBPdelta were found to physically interact with Smad3 and Smad4, and Smad3 cooperated with Smad4 and TGF-beta signaling to repress the transcriptional activity of C/EBPs. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253538 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17139329 |
Phosphorylation of receptor-regulated SMADs (for example, SMAD1 or SMAD3) stimulates dimer formation with SMAD4 and translocation to the nucleus, where the SMADs regulate the transcription of target gene SMAD3 binds to C/EBPs and inhibits their transcriptional activity, including their ability to transactivate the Pparg2 promoter |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
EGR2 | up-regulates quantity by expression
transcriptional regulation
|
CEBPB |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139292 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16054051 |
Ectopic expression of krox20 can transactivate the c/ebpbeta promoter and increase c/ebpbeta gene expression in 3t3-l1 preadipocytes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | up-regulates
phosphorylation
|
CEBPB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270045 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19327116 |
Thr235 phosphorylation occurs in nuclei of differentiated macrophages, but not in monocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
GDF15 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254050 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 24086573 |
Promoter analysis and chromatin immunoprecipitation analysis revealed that CEBPB could contribute to K7174-mediated transcriptional activation of GDF15. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
SLC5A8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254054 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20082847 |
Luciferase reporter assays of deletion mutants of SLC5A8 promoter demonstrated that a 295-bp region is essential for the basal promoter activity of the SLC5A8 gene. Further analysis indicated that the CCAAT boxes and GC boxes were involved in positive regulation of SLC5A8 promoter. Overexpression of two transcription factors, CCAAT/enhancer binding protein beta (C/EBPbeta) and specific transcription factor 1 (Sp1), upregulated the activities of the human SLC5A8 promoter and protein expression, suggesting that both C/EBPbeta and Sp1 transcription factors might have functions in SLC5A8 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
SLC19A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15652157 |
Collectively, these results identify transcriptionally important regions in the hRFC-C minimal promoter that include a GC-box and CCAAT-box, and suggest that cooperative interactions between Sp1 and C/EBP beta are essential for hRFC-C transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250572 |
|
|
|
|
| pmid |
sentence |
| 16319681 |
The transcription factor C/EBPalpha controls differentiation and proliferation in normal granulopoiesis in a stage-specific manner. Loss of C/EBPalpha function in myeloid cells in vitro and in vivo leads to a block to myeloid differentiation similar to that which is observed in malignant cells from patients with acute myeloid leukemia. The finding of C/EBPalpha alterations in subgroups of acute myeloid leukemia patients suggests a direct link between critically decreased C/EBPalpha function and the development of the disorder. |
|
| Publications: |
1 |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
miR-155 | down-regulates quantity by repression
post transcriptional regulation
|
CEBPB |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255795 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25477897 |
The down-regulation of miR-29b is thought to promote DNA hypermethylation in AML since miR-29b can directly target DNMT3A, DNMT3B, and Sp1 (a transcriptional regulator of DNMT3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
HSD11B1 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268972 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19088256 |
In conclusion, C/EBPalpha and C/EBPbeta control basal transcription, and TNF-alpha upregulates 11beta-HSD1, most likely by p38 MAPK-mediated increased binding of C/EBPbeta to the human HSD11B1 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3-isobutyl-1-methyl-7H-xanthine | up-regulates
|
CEBPB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210068 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8754811 |
The differentiation of 3t3 preadipocytes into adipocytes is accompanied by a transient induction of c/ebpbeta and c/ebpdelta expression in response to treatment of the cells with methylisobutylxanthine (mix) and dexamethasone (dex), respectively |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209986 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates activity
binding
|
CEBPB |
0.461 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250566 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 11279134 |
The differentiation of 3T3-L1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the CCAAT/enhancer-binding proteins (C/EBPs) and peroxisome proliferator-activated receptor gamma (PPARgamma) by dexamethasone (DEX), 3-isobutyl-1-methylxanthine (MIX), and insulin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251655 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9428795 |
We have shown that one of the functions of the GR to activate transcription of the AGP gene is to recruit C/EBPbeta and to maintain it bound at its target DNA sequences (SRU) |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Rattus Norvegicus |
| Pathways: | Adipogenesis |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
ADM |
0.245 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254047 |
|
|
|
|
| pmid |
sentence |
| 9480831 |
These findings suggest that NF-IL6 and AP-2 sites in the promoter region are the functional elements in the transcriptional regulation of human AM gene in vascular endothelial cells. |
|
| Publications: |
1 |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
ABCB1 |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253771 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15044620 |
C/EBPbeta activates the endogenous MDR1 gene of MCF-7 cells, and this activation was associated with a novel C/EBPbeta interaction region within the proximal MDR1 promoter (-128 to -75). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK40 | down-regulates quantity by destabilization
binding
|
CEBPB |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261925 |
|
|
Mus musculus |
Microglia |
| pmid |
sentence |
| 32795415 |
The COP1-interacting protein STK40 (Durzynska et al., 2017), which was detected in c/EBPβ complexes from BMDMs (Figure 1B), also appeared to contribute to the suppression of c/EBPβ in microglia. Specifically, deletion of the STK40 pseudokinase increased the amount of c/EBPβ protein without increasing the amount of Cebpb mRNA |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
TNFAIP6 |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254055 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7876106 |
In cotransfection experiments, the C/EBP beta protein trans-activated 10-15-fold the cAspAT gene promoter in HepG2 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | down-regulates quantity by repression
transcriptional regulation
|
CEBPB |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184280 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19254573 |
Sox9 directly binds to the promoter regions of c/ebpbeta and c/ebpdelta to suppress their promoter activity, preventing adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
S100A9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254044 |
|
|
Homo sapiens |
THP-1 Cell |
| pmid |
sentence |
| 9706399 |
Among several known transcription factor binding motifs, nuclear protein(s) of VD3-treated HL-60 cells and THP-1 cells bound to the CCAAT/enhancer binding protein (C/EBP)-binding motif that was located in the upstream region of the MRP14 gene (-81), as evidenced by the competitive gel mobility-shift assay.|Thus, it was concluded that C/EBP alpha and -beta were able to bind to the C/EBP motif, and that C/EBP alpha bound to the motif in THP-1 cells and C/EBP beta bound to that in the VD3-treated HL-60 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
CEBPB | up-regulates activity
|
Neurodegeneration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261926 |
|
|
Mus musculus |
Microglia |
| pmid |
sentence |
| 32795415 |
In the absence of COP1, c/EBPβ accumulates rapidly and drives a potent pro-inflammatory and neurodegeneration-related gene program, evidenced by increased neurotoxicity in microglia-neuronal co-cultures. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KLHL9 | down-regulates quantity by destabilization
binding
|
CEBPB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272458 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 25303533 |
KLHL9 mediates poly-ubiquitylation of C/EBPβ and C/EBPδ isoforms. We confirmed KLHL9 deletions in an independent cohort and showed that this protein is necessary for Cul3-ligase mediated ubiquitylation and proteasomal degradation of established MES-GBM MRs, C/EBPβ and C/EBPδ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | up-regulates
|
CEBPB |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250565 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
GATA3 | down-regulates
binding
|
CEBPB |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132952 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15632071 |
In the present study, we demonstrate that both gata-2 and gata-3 form protein complexes with ccaat/enhancer binding protein alpha (c/ebpalpha) and c/ebpbeta, members of a family of transcription factors that are integral to adipogenesis. []the interaction between gata and c/ebp factors is critical for the ability of gata to suppress adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Cullin 3-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
CEBPB |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272456 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 25303533 |
KLHL9 mediates poly-ubiquitylation of C/EBPβ and C/EBPδ isoforms. We confirmed KLHL9 deletions in an independent cohort and showed that this protein is necessary for Cul3-ligase mediated ubiquitylation and proteasomal degradation of established MES-GBM MRs, C/EBPβ and C/EBPδ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CEBPB
- 
- 