Summary

Name CEBPB
Full Name CCAAT/enhancer-binding protein beta
Synonyms C/EBP beta, Liver activator protein, LAP, Liver-enriched inhibitory protein, LIP, Nuclear factor NF-IL6, Transcription factor 5, TCF-5 | TCF5
Primary ID P17676
Links - -
Type protein
Relations 57
Pathways Adipogenesis
Function Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.31
Publications: 3 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.28
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.31
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CSRP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation PPARG 0.42
Publications: 2 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png binding CEBPB 0.31
Publications: 2 Organism: Mus Musculus, Rattus Norvegicus
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png transcriptional regulation, binding CEBPB 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation, CEBPB 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation CEBPB 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation CEBPB 0.34
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png CEBPB 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GFER 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PCK2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF5 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ADM 0.14
Publications: 1
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GDF15 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation CEBPB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPB 0.31
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates img/indirect-activation.png Adipogenesis 0.4
Publications: 2 Organism: Mus Musculus,
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png binding CEBPB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPB 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CEBPB 0.14
Publications: 1
+ up-regulates img/indirect-activation.png CEBPB 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPB 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png post transcriptional regulation CEBPB 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPB 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SFTPD 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLC19A1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLC5A8 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation STAR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TNFAIP6 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CEBPB 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates img/indirect-activation.png CEBPB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Differentiation 0.14
Publications: 1
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation S100A9 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GOT1 0.14
Publications: 1
+ up-regulates quantity img/direct-activation.png transcriptional regulation SREBF1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CEBPB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CEBPB 0.14
Publications: 1 Organism: Mus Musculus