Summary

Name CEBPB
Full Name CCAAT/enhancer-binding protein beta
Synonyms C/EBP beta, Liver activator protein, LAP, Liver-enriched inhibitory protein, LIP, Nuclear factor NF-IL6, Transcription factor 5, TCF-5 | TCF5
Primary ID P17676
Links - -
Type protein
Relations 66
Pathways Adipogenesis, Acute Myeloid Leukemia, miRNA in AML, FAP: In vitro induction of adipogenesis, FAP: Adipogenic transcriptional cascade, FAP: Glucocorticoids, FAP: IBMX/rosiglitazone, FAP: Notch, FAP: SHH, FAP: TGF beta, FAP: GCR-cAMP crosstalk, FLT3-ITD signaling, FAP: miRNA and adipogensis, Monocyte: IL10 transcriptional regulation, Pericyte: In vitro induction of adipogenesis
Function Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.459
Publications: 3 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.327
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.396
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.715
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.338
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.459
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.667
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.275
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png CEBPB 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPB 0.461
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png binding CEBPB 0.559
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation SREBF1 0.412
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PCK2 0.328
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CEBPB 0.596
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SFTPD 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GOT1 0.2
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GFER 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png post transcriptional regulation CEBPB 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ up-regulates activity img/direct-activation.png binding CREB1 (isoform 1) 0.563
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPB 0.297
Publications: 1
Pathways:Acute Myeloid Leukemia, miRNA in AML, FLT3-ITD signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF5 0.701
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPB 0.563
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, FLT3-ITD signaling
+ up-regulates img/indirect-activation.png CEBPB 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Adipogenesis 0.7
Publications: 2 Organism: Mus Musculus,
Pathways:Adipogenesis
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation CEBPB 0.669
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png CEBPB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CEBPB 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation C3 0.259
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.357
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation STAR 0.366
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CSRP1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation CEBPB 0.326
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation PPARG 0.728
Publications: 2 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png binding, transcriptional regulation CEBPB 0.577
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CEBPB 0.532
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GDF15 0.276
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLC5A8 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLC19A1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Differentiation 0.7
Publications: 1
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation CEBPB 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HSD11B1 0.285
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CEBPB 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CEBPB 0.461
Publications: 2 Organism: Mus Musculus, Rattus Norvegicus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ADM 0.245
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.445
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CEBPB 0.28
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TNFAIP6 0.302
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPB 0.326
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation S100A9 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates activity img/indirect-activation.png Neurodegeneration 0.7
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CEBPB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CEBPB 0.428
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates img/direct_inhibition.png binding CEBPB 0.353
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination CEBPB 0.268
Publications: 1 Organism: Homo Sapiens