Summary

Name CEBPA
Full Name CCAAT/enhancer-binding protein alpha
Synonyms C/EBP alpha | CEBP
Primary ID P49715
Links - -
Type protein
Relations 54
Pathways Acute Myeloid Leukemia, Adipogenesis, AML1-ETO, AML-FLT3, AML_TF
Function Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png sumoylation CEBPA 0.08
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CEBPA 0.17
Publications: 2 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/indirect-activation.png CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CEBPA 0.17
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO
+ up-regulates img/indirect-activation.png Differentiation 0.47
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO, AML-FLT3
+ up-regulates img/indirect-activation.png CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPA 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SFTPD 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation STAR 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation CEBPA 0.30
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, AML1-ETO, AML-FLT3, AML_TF
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPA 0.08
Publications: 1 Organism: Mus Musculus
Pathways:AML_TF
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation F9 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPA 0.17
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-FLT3
+ down-regulates activity img/direct_inhibition.png binding CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation CEBPA 0.17
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, AML-FLT3
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation CEBPA 0.28
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ELANE 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation SPI1 0.08
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML1-ETO, AML_TF
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation GFI1 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:AML_TF
+ down-regulates img/indirect_inhibition.png CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png transcriptional regulation CEBPA 0.17
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HAMP 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYC 0.17
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-FLT3
+ down-regulates img/direct_inhibition.png transcriptional regulation CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPA 0.08
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:AML1-ETO
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER2 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CEBPA 0.17
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CEBPA 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates img/indirect-activation.png Adipogenesis 0.22
Publications: 2 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates img/direct_inhibition.png binding CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPA 0.08
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, AML-FLT3
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CEBPA 0.17
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-FLT3
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation S100A9 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding USF1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPA 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png transcriptional regulation SOX4 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:AML1-ETO
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CEBPA 0.08
Publications: 1 Organism: Homo Sapiens