Summary

Name GSK3B
Full Name Glycogen synthase kinase-3 beta
Synonyms GSK-3 beta, Serine/threonine-protein kinase GSK3B, 2.7.11.1
Primary ID P49841
Links - -
Type protein
Relations 337
Pathways Adipogenesis, Alzheimer, Acute Myeloid Leukemia, AML_TRIPLETS, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Sonic Hedgehog, Insulin Signaling, MTOR Signaling, Triple mutant AML, PI3K/AKT Signaling, WNT/FLT3
Inhibitors CHIR-98014; CHIR 99021; 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol; 3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; 3-(9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione
Function Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and ARNTL/BMLA1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation SNAI1 0.579
Publications: 14 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.35
Publications: 4 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDKN1A 0.415
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation FBXO4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MUC1 0.472
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.682
Publications: 1 Organism: Rattus Norvegicus
Pathways:Adipogenesis, FLT3-ITD signaling, PI3K/AKT Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CAMKK2 0.276
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PHLPP1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.787
Publications: 1 Organism: Homo Sapiens
Pathways:WNT/FLT3
+ img/unknown.png phosphorylation CABYR 0.411
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation BCL2L12 0.349
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TCAP 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MCL1 0.518
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MCL1 0.518
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png phosphorylation RCAN1 0.498
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation BAX 0.384
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer, Acute Myeloid Leukemia, FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png phosphorylation ARNTL 0.396
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPIF 0.391
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RBM38 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NOTCH2 0.498
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FGF14 0.263
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.472
Publications: 3 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation JUN 0.698
Publications: 3 Organism: Homo Sapiens, In Vitro
Pathways:Acute Myeloid Leukemia, Insulin Signaling, WNT/FLT3
+ img/unknown.png phosphorylation CTNND1 0.396
Publications: 2 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation ATXN3 0.481
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation PDX1 0.2
Publications: 4 Organism: Mus Musculus
Pathways:Insulin Signaling
+ down-regulates img/direct_inhibition.png phosphorylation GPHN 0.289
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation BORA 0.262
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CDX2 0.39
Publications: 4 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation FCAR 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation HDAC4 0.371
Publications: 2 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation DROSHA 0.283
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation HSF1 0.537
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation HSF1 0.537
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KLF5 0.376
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png phosphorylation CAP1 0.256
Publications: 2 Organism: Homo Sapiens
Tissue: Lung
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.857
Publications: 12 Organism: Homo Sapiens, In Vitro
Tissue: Brain, Colonic Cancer Cell
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling, WNT/FLT3
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.716
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML_TRIPLETS, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Triple mutant AML
+ up-regulates activity img/direct-activation.png phosphorylation DCX 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCE 0.272
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PSEN1 0.61
Publications: 2 Organism: Homo Sapiens
Pathways:Alzheimer
+ down-regulates activity img/direct_inhibition.png phosphorylation GRB14 0.328
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.352
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFE2L1 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.295
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
Pathways:FLT3-ITD signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ZNF322 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAPT 0.729
Publications: 11 Organism: Homo Sapiens,
Tissue: Brain
Pathways:Alzheimer
+ down-regulates activity img/direct_inhibition.png phosphorylation NR3C1 0.519
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SREBF1 0.503
Publications: 5 Organism: Homo Sapiens
Pathways:Insulin Signaling, MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation MYOCD 0.408
Publications: 8 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ACLY 0.372
Publications: 2
+ up-regulates img/direct-activation.png phosphorylation RELA 0.366
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png phosphorylation AXIN1 0.917
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAFA 0.261
Publications: 4 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MAFA 0.261
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NEFH 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT 0.729
Publications: 13 Organism: Homo Sapiens
Pathways:Alzheimer
+ up-regulates activity img/direct-activation.png phosphorylation DPYSL3 0.447
Publications: 3 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation DPYSL2 0.712
Publications: 4 Organism: Rattus Norvegicus, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CRMP1 0.442
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DPYSL3 0.447
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation CLASP2 0.532
Publications: 2 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF2B5 0.556
Publications: 2 Organism: In Vitro, Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation, binding EIF2B5 0.556
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NR1D1 0.288
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SNCAIP 0.503
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BICD1 0.336
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STMN3 0.269
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ZNF281 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation UNG 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GYS1 0.671
Publications: 8 Organism: In Vitro, , Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Insulin Signaling, PI3K/AKT Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation MACF1 0.448
Publications: 9 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png phosphorylation CDC25A 0.32
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ down-regulates img/direct_inhibition.png phosphorylation MNX1 0.302
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GLI2 0.541
Publications: 3 Organism: Homo Sapiens
Pathways:Sonic Hedgehog
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPD 0.352
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HNRNPD 0.352
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDH1 0.58
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation KAT5 0.38
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation ROR2 0.317
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML_TRIPLETS, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Insulin Signaling, MTOR Signaling, Triple mutant AML, PI3K/AKT Signaling, WNT/FLT3
+ up-regulates activity img/direct-activation.png dephosphorylation GSK3B 0.42
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.601
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, AML_TRIPLETS, FLT3-ITD signaling, Insulin Signaling, MTOR Signaling, Triple mutant AML, PI3K/AKT Signaling, WNT/FLT3
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.574
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.367
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, MTOR Signaling
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, PI3K/AKT Signaling
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.39
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.2
Publications: 1
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.536
Publications: 1 Organism: Homo Sapiens
Pathways:Sonic Hedgehog, WNT/FLT3
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.299
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.364
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.455
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.2
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation, GSK3B 0.778
Publications: 3 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Adipogenesis, FLT3-ITD signaling, IGF and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.718
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation GSK3B 0.477
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png dephosphorylation GSK3B 0.2
Publications: 1
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation NFKB1 0.397
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation SPAG5 0.275
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H1-5 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AKAP11 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN8A 0.2
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation SCN2A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NACA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CEBPA 0.388
Publications: 2 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, AML_TRIPLETS, Triple mutant AML
+ up-regulates activity img/direct-activation.png phosphorylation NIFK 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB 0.472
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation RELA 0.366
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation CCND2 0.432
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CCND3 0.412
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CCND1 0.775
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML_TRIPLETS, Triple mutant AML
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CCND1 0.775
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML_TRIPLETS, Triple mutant AML
+ up-regulates activity img/direct-activation.png phosphorylation FBXL21P 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.44
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Insulin Signaling, MTOR Signaling, PI3K/AKT Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF4EBP1 0.376
Publications: 3 Organism: Homo Sapiens
Tissue: Kidney
Pathways:Insulin Signaling, MTOR Signaling, PI3K/AKT Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CCNE1 0.457
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.39
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.299
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DPYSL5 0.401
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MYC 0.709
Publications: 3 Organism: Rattus Norvegicus, Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML_TRIPLETS, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Triple mutant AML, WNT/FLT3
+ down-regulates activity img/direct_inhibition.png phosphorylation NBR1 0.442
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SMAD3 0.505
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition
+ down-regulates img/direct_inhibition.png phosphorylation SFPQ 0.352
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R2 0.421
Publications: 1 Organism: Bos Taurus
+ img/unknown.png phosphorylation APP 0.564
Publications: 1 Organism: In Vitro
Pathways:Alzheimer
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation AREL1 0.321
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation ARHGAP31 0.309
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation GSK3B 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Alzheimer, Acute Myeloid Leukemia, AML_TRIPLETS, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Sonic Hedgehog, Insulin Signaling, MTOR Signaling, IGF and Myogenesis, Triple mutant AML, PI3K/AKT Signaling, WNT/FLT3
+ up-regulates activity img/direct-activation.png phosphorylation GSK3B 0.351
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates activity img/direct-activation.png phosphorylation GSK3B 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
Pathways:Adipogenesis, Acute Myeloid Leukemia, AML_TRIPLETS, FLT3-ITD signaling, Insulin Signaling, PI3K/AKT Signaling
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EIF2B1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAF 0.265
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation OSBP2 0.2
Publications: 1
+ up-regulates activity img/direct-activation.png binding GSK3B 0.314
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage GSK3B 0.291
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png GSK3B 0.787
Publications: 1
Pathways:WNT/FLT3
+ up-regulates img/direct-activation.png binding, phosphorylation AXIN1 0.917
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GLI3 0.514
Publications: 2 Organism: Drosophila Melanogaster, Mus Musculus
Pathways:Sonic Hedgehog
+ down-regulates img/indirect_inhibition.png GSK3B 0.448
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding GSK3B 0.605
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, WNT/FLT3
+ down-regulates img/direct_inhibition.png chemical inhibition GSK3B 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CyclinD/CDK4 0.603
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, IGF and Myogenesis
+ down-regulates img/direct_inhibition.png chemical inhibition GSK3B 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition GSK3B 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding GSK3B 0.389
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition GSK3B 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAML1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP1B 0.547
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GSK3B 0.56
Publications: 2 Organism: Homo Sapiens
Pathways:WNT/FLT3
+ up-regulates activity img/indirect-activation.png NfKb-p65/p50 0.381
Publications: 1
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png binding EIF2B4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAFB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.367
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, PI3K/AKT Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LGALS3 0.349
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition GSK3B 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates img/indirect_inhibition.png Protein_synthesis 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Insulin Signaling, MTOR Signaling, PI3K/AKT Signaling
+ up-regulates activity img/direct-activation.png cleavage GSK3B 0.276
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFATC2 0.541
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation NOTCH1 0.478
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation APC 0.746
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EIF2B2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TSC2 0.72
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/indirect_inhibition.png GSK3B 0.424
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png binding EIF2B3 0.265
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NfKb-p65/p50 0.381
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation GSK3B 0.272
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.2
Publications: 1
Pathways:Acute Myeloid Leukemia, AML_TRIPLETS, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Insulin Signaling, MTOR Signaling, Triple mutant AML, PI3K/AKT Signaling, WNT/FLT3
+ down-regulates activity img/direct_inhibition.png binding GSK3B 0.678
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GSK3B 0.823
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney, Lung
+ down-regulates activity img/indirect_inhibition.png CHEK1 0.303
Publications: 1 Organism: Mus Musculus
Pathways:FLT3-ITD signaling, Cell cycle: G2/M phase transition
+ down-regulates img/direct_inhibition.png phosphorylation NEB 0.315
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage GSK3B 0.303
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ down-regulates img/direct_inhibition.png binding MAPK14 0.295
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ form complex img/form-complex.png binding GSK3B/Axin/APC 0.832
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAFB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GSK3B 0.761
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization GSK3B 0.388
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD1 0.52
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAF 0.265
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png GSK3B 0.474
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:Adipogenesis, Insulin Signaling, MTOR Signaling
+ down-regulates img/indirect_inhibition.png GSK3B 0.386
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/indirect-activation.png GSK3B 0.409
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding GSK3B 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAP3K4 0.374
Publications: 1 Organism: Homo Sapiens