Summary

Name MAPK3
Full Name Mitogen-activated protein kinase 3
Synonyms MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1 | ERK1, PRKM3
Primary ID P27361
Links - -
Type protein
Relations 398
Pathways Glucocorticoid receptor Signaling
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation JUND 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HDAC6 0.436
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.691
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LIFR 0.302
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation POU5F1 0.347
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PPARG 0.404
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SOS1 0.619
Publications: 5 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SREBF1 0.454
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCOA1 0.269
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates activity img/direct-activation.png phosphorylation PPARA 0.586
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TAL1 0.365
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIC 0.381
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation THRB 0.409
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.695
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRB10 0.301
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BRAF 0.633
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TOB1 0.356
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BAZ1B 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DUSP6 0.851
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation POLR2A 0.322
Publications: 23 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTTG1 0.308
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RCAN1 0.388
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.511
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation PCBP2 0.329
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAGEA11 0.305
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation APBB1 0.269
Publications: 4 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MITF 0.523
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation PAX5 0.248
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KARS1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MCRIP1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CEBPA 0.377
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ETV6 0.322
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation NUP50 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.723
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens, Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.711
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens, Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation SPHK1 0.586
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ABI1 0.431
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.522
Publications: 1 Organism: In Vitro
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.722
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD2 0.737
Publications: 15 Organism: Homo Sapiens
Tissue: Lung, Breast, Lung
+ down-regulates activity img/direct_inhibition.png phosphorylation STMN1 0.564
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GJA1 0.626
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RXRA 0.505
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAPT (isoform 2)
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation HSPB8 0.347
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation HSPB8 0.347
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ALOX5 0.331
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.348
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOXA1 0.269
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HNRNPK 0.351
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPK 0.351
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIITA 0.348
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAF1 0.624
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation TFCP2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AMPH 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RUNX2 0.545
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PGR 0.542
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3 0.579
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.579
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AMPH 0.277
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation DUSP1 0.778
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.624
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSF1 0.617
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PCYT1A 0.443
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ down-regulates activity img/direct_inhibition.png phosphorylation NUP50 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IRX2 0.2
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.587
Publications: 6 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCL6 0.412
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PPP2R5C 0.396
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1 0.428
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DUSP1 0.778
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA5 0.57
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.704
Publications: 6 Organism: , Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ASB2 0.268
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.57
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.619
Publications: 6 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.706
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation SPHK2 0.504
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTTN 0.431
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARRB1 0.705
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation XPO5 0.317
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB10 0.301
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation METTL3 0.275
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SREBF2 0.401
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KRT8 0.429
Publications: 2 Organism: , Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KB1 0.592
Publications: 3 Organism: Rattus Norvegicus, Homo Sapiens
Tissue: Carcinoma Cell
+ down-regulates img/direct_inhibition.png phosphorylation MRTFA 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KLC1 0.267
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SYN3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAPN2 0.547
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLA2G4A 0.644
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation JAK2 0.503
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NUP153 0.401
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PML 0.345
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYB 0.305
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.68
Publications: 3 Organism: Mus Musculus, Homo Sapiens
+ img/unknown.png phosphorylation WWC1 0.273
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation SP1 0.64
Publications: 6 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates activity img/direct-activation.png phosphorylation LCK 0.55
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.695
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TH 0.493
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation STMN2 0.36
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation MYC 0.694
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation GAB2 0.602
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EPS8 0.328
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation JUN 0.771
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation RRN3 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIF1A 0.686
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GTF2I 0.383
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GRK2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NFATC4 0.292
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TWIST1 0.331
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ARHGAP26 0.2
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BCL2L11 0.719
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPTOR 0.479
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.544
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PDE4D 0.253
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.707
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.707
Publications: 4 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation SP3 0.303
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS2 0.358
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALD1 0.459
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle, Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.324
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT5A 0.693
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation IL16 0.268
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B 0.298
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PTPN7 0.682
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PLCB1 0.422
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MED1 0.265
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SULT4A1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation UBTF 0.563
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.548
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MCL1 0.443
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LAT 0.307
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.381
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3 0.698
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3 0.2
Publications: 3 Organism: , Homo Sapiens
Tissue: Heart
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.634
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3 0.778
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.745
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.735
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Heart
+ down-regulates img/direct_inhibition.png phosphorylation MBP 0.514
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation FOS 0.704
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CEBPB 0.655
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TRPV3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD4 0.426
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PAK1 0.343
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TCF3 0.38
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PTPRR 0.659
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation ETS1 0.66
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MKNK1 0.56
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS3 0.356
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS3 0.356
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.298
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SP1 0.64
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAD 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation BCL2 0.544
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SPIB 0.317
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1B 0.282
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SCNN1G 0.283
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ARHGEF2 0.293
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.73
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.539
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAZ 0.303
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ADAM17 0.366
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BRAF 0.633
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EWSR1 0.267
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2 0.737
Publications: 3 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates activity img/direct-activation.png phosphorylation LIPE 0.425
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3 0.652
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.55
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK3 0.471
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.444
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.46
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png BRD4 0.316
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MKNK2 0.498
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation mTORC1 0.39
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MAPK3 0.522
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid receptor Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPKAPK2 0.489
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation mTORC1 0.39
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation THR 0.425
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.851
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD1 0.509
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAPK3 0.611
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png dephosphorylation MAPK3 0.443
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA2 0.711
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3 0.735
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png MAPK3 0.584
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.316
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCKIPSD 0.431
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3 0.745
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation SMAD3 0.606
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.75
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation E2F1 0.294
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX9 0.388
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.471
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization PPARG 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MYL1 0.29
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK3 0.585
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK3 0.396
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation SOX9 0.388
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA4 0.571
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.737
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation mTORC1 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK3 0.591
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK3 0.489
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MKNK1 0.56
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.456
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B/Axin/APC 0.355
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png MAPK3 0.762
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK3 0.694
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.778
Publications: 1 Organism: Homo Sapiens